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Solvent enabling oil and water to be co-dissolved in skin and penetrate through skin and applications of solvent

A transdermal, oil-water technology, applied in the direction of skin care preparations, cosmetic preparations, medical preparations containing active ingredients, etc., can solve side effects such as skin irritation, safety concerns, easy breakage and failure, etc., to reduce Stimulating, stability-enhancing effects

Inactive Publication Date: 2017-12-08
张严
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, liposome technology requires a series of steps such as liposome construction, and is prone to rupture and failure during storage
[0013] Chinese patent CN101732210A discloses a composite nanoemulsion used for skin anti-allergy to improve transdermal absorption, but this method requires the construction of microspheres smaller than 100 nanometers
[0014] In addition, there are concerns about side effects such as skin irritation and / or safety issues in preparations of skin permeation enhancers.

Method used

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  • Solvent enabling oil and water to be co-dissolved in skin and penetrate through skin and applications of solvent
  • Solvent enabling oil and water to be co-dissolved in skin and penetrate through skin and applications of solvent
  • Solvent enabling oil and water to be co-dissolved in skin and penetrate through skin and applications of solvent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Composition of oil-water co-dissolving into skin transdermal solvent (wt):

[0044]

[0045] After mixing evenly, add L-ascorbic acid to make the concentration 25%wt to obtain an essence provided by the invention.

Embodiment 2

[0047] A total of 49 subjects with obvious chloasma on the face received the test of the essence provided in Example 1 for two months and three months respectively. Under self-evaluation, the subjects of two months About 46.25% think it is effective, and about 72.22% of the three-month testees think it is effective.

Embodiment 3

[0049] 30 faces have obvious chloasma male test subjects (A sample) and 39 faces have obvious chloasma female test subjects (B sample), also accept the light spots of the essence provided by embodiment 1 test. Under the image numerical test, the average melanin value of sample A was 64.2 before the test, which dropped to 43.1 after one month of use, 37.2 after two months of continuous use, and 21.4 by the third month. The average melanin value of sample B was 62.8 before the test, which dropped to 45.5 after one month of use, 35.8 after two months of continuous use, and 17.9 in the third month. as attached figure 1 shown.

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PUM

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Abstract

The invention provides a solvent enabling oil and water to be co-dissolved in the skin and penetrate through the skin and applications of the solvent. The solvent enabling oil and water to be co-dissolved in the skin and penetrate through the skin provided by the invention comprises the following components: one or more of polyols, one or more of polyethylene glycols, isosorbide dimethyl ether and sorbitan stearate. The invention further provides applications of the solvent in essence, wherein the essence further comprises active ingredients. For the solvent enabling oil and water to be co-dissolved in the skin and penetrate through the skin provided by the invention, the active substances can be dissolved in the solvent, so that the active ingredients can penetrate through the skin without the aid of an instrument, and then the effects of the active ingredients are fully exerted.

Description

technical field [0001] The invention relates to a solvent and its application, in particular to an oil-water co-dissolving into skin transdermal solvent and its application. Background technique [0002] Transdermal absorption of active ingredients plays an important role in both skin care and medical treatment. However, not all drugs can be used in transdermal drug delivery systems because most active ingredients cannot effectively penetrate the skin. Since commercially available essences do not have skin-penetrating technology, they can only enter through pores, and their efficacy is limited. [0003] To increase the transdermal properties of active ingredients, it is necessary to reduce the diffusion resistance through reversible damage to change the physical and chemical properties of the stratum corneum or subcutaneous fat layer of the skin, or to increase the solubility of active ingredients in the skin to increase its skin permeability , to obtain sufficient skin pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/34A61K8/39A61Q19/00
CPCA61K8/345A61K8/39A61K8/4973A61K2800/10A61Q19/00
Inventor 张严
Owner 张严