Three-dimensional hierarchical-pore gel based on fluorescent mesoporous silica nanorods and preparation method thereof

A technology of mesoporous silica and nanorods, applied in the field of porous nanomaterials, can solve problems such as difficulty in making three-dimensional hierarchical porous fluorescent gels, and achieve the effect of being suitable for large-scale production, and the process is simple and efficient.

Active Publication Date: 2017-12-12
深圳市科力恩生物医疗有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, endowing the hierarchical porous gel with fluorescent properties can also make it easy to monitor the gel carrier through fluorescence imaging, but the conventional method of preparing fluorescent mesoporous silica is difficult to make a three-dimensional hierarchical porous fluorescent gel

Method used

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  • Three-dimensional hierarchical-pore gel based on fluorescent mesoporous silica nanorods and preparation method thereof
  • Three-dimensional hierarchical-pore gel based on fluorescent mesoporous silica nanorods and preparation method thereof
  • Three-dimensional hierarchical-pore gel based on fluorescent mesoporous silica nanorods and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] (1) Prepare a silane coupling agent RITC-APTES with fluorescent functional groups.

[0035] Under the protection from light and stirring, completely dissolve 26.8 mg of rhodamine B isothiocyanate (abbreviated as RITC) in 10 mL of anhydrous methanol, then add 50 μL of aminopropyltriethoxysilane (abbreviated as APTES) dropwise, and stir Two days later, a silane coupling agent with fluorescent functional groups (RITC-APTES for short) was obtained.

[0036] (2) Preparation of RITC-labeled fluorescent hierarchical porous gel

[0037] Add 0.3mL of RITC-APTES solution to 20g of 10wt% triethanolamine solution, stir, pre-hydrolyze for 10min, then add 2g of 25wt% cetyltriethylammonium chloride solution, and stir in an 80-degree oil bath 30min. Then 1.5 mL of tetraethyl orthosilicate was added dropwise (3 seconds per drop). After reacting in the dark for 1 h, the gel was separated and washed with ethanol. Use a mixed solution of 40mL ethanol and 0.5mL concentrated hydrochloric...

Embodiment 2

[0042] Add 0.3mL of RITC-APTES solution into 10g of 10wt% triethanolamine solution, stir, and pre-hydrolyze for 10min. Then 2g of 25wt% cetyltriethylammonium chloride solution and 8mL of water were added, and stirred in an oil bath at 80°C for 30min. Then 1.5 mL of ethyl orthosilicate was added dropwise. After reacting in the dark for 1 h, the gel was separated and washed with ethanol. Use a mixed solution of 40mL ethanol and 0.5mL concentrated hydrochloric acid to extract the surfactant, heat at 80°C for 8 hours, then wash with ethanol hydrochloric acid solution, and repeat the extraction operation twice. Finally dispersed in ethanol solution, refrigerated and protected from light.

[0043] image 3 The TEM photo of the three-dimensional hierarchical porous fluorescent gel prepared in Example 2 is shown. From image 3 It can be seen that the gel material is a hierarchical porous structure constructed of ordered mesoporous nanorods, and the diameter of the macropore is abou...

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Abstract

The invention discloses a three-dimensional hierarchical-pore gel based on fluorescent mesoporous silica nanorods. The gel has a three-dimensional hierarchical-pore structure established by covalently bridging the mesoporous silica nanorods through top ends, the mesoporous silica nanorods for establishing the gel have transverse-perpendicular pore channel structures, and fluorescent molecules are covalently grafted in mesoporous channels of the mesoporous silica through mono-dispersion. The invention also provides a preparation method of the three-dimensional hierarchical-pore gel based on the fluorescent mesoporous silica nanorods. The preparation method adopts one-step assembly, is simple and efficient and can be carried out in a large-scale mode. The prepared gel is established based on the mesoporous silica nanorods, thus has the three-dimensional hierarchical-pore structure and is conductive to simultaneous loading and combined treatment of cross-size drug molecules. The mesoporous silica nanorods have small diameters (25 nanometers) and vertical mesoporous channels and are conductive to diffusion of supported drug molecules, and the three-dimensional hierarchical-pore gel has the wide application prospect in the field of biological medicine.

Description

technical field [0001] The invention relates to a three-dimensional hierarchical porous gel based on fluorescent mesoporous silica nanorods and a preparation method thereof, belonging to the technical field of porous nanomaterials. Background technique [0002] Gels with high specific surface area and hierarchical pore structure have unique advantages and broad application prospects in the fields of drug loading, catalytic reaction, adsorption and separation, etc. Generally, it is difficult for mesoporous silica gel to form an ordered mesoporous structure and a three-dimensional hierarchical porous network structure, and silica with a three-dimensional hierarchical porous network structure cannot form an ordered mesoporous structure. For example, CN103159221B (patent right has been terminated), CN101804989B (patent right has been terminated) and CN101811702B (patent right has been terminated) disclose a class of mesoporous silica gels, all of which only have a mesoporous s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/00C09K11/02C09K11/06C09K11/59
CPCB01J13/0056B01J13/0065C09K11/025C09K11/06C09K11/59C09K2211/1088
Inventor 温艳媛何前军
Owner 深圳市科力恩生物医疗有限公司
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