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Pectin solution for treating antibiotic associated diarrhea and preparation method thereof

A correlation and antibiotic technology, applied in the directions of pharmaceutical formulation, dispersion liquid delivery, digestive system, etc., to achieve the effect of convenient use, simple preparation method and obvious therapeutic effect

Inactive Publication Date: 2017-12-15
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research of pectin on antibiotic-associated diarrhea has not been reported so far

Method used

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  • Pectin solution for treating antibiotic associated diarrhea and preparation method thereof
  • Pectin solution for treating antibiotic associated diarrhea and preparation method thereof
  • Pectin solution for treating antibiotic associated diarrhea and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, a kind of preparation method of the pectin solution for the treatment of antibiotic-associated diarrhea comprises the following steps:

[0022] Pectin solution preparation: use amidated low methoxyl pectin APA200, dissolve in 0.05N sodium chloride according to 1.0% (W / V, that is, 10g / 1000ml), boil at 100°C for 15 minutes, and treat antibiotic-related Pectin solution for diarrhea (referred to as pectin solution).

Embodiment 2

[0023] Embodiment 2, change 1.0% (W / V) into 1.5% (W / V), all the other are equal to embodiment 1.

Embodiment 3

[0024] Embodiment 3, 1.0% (W / V) is changed into 2.0% (W / V), all the other are equal to embodiment 1.

[0025] Experiment 1. Experiments on the treatment of antibiotic-associated diarrhea:

[0026] (1) Model construction:

[0027] SPF / VAF grade 5-week-old SD rats were purchased, half male and half male, and the rats were raised in a rat cage with an air filter membrane on the top, and fostered in the SPF grade animal room of Zhejiang University. ①Normal rats: Rats drank sterile water and food freely. ②Clindamycin model rats: 2ml clindamycin (25mg / ml) was administered to the rats by intragastric administration once a day for 7 consecutive days; antibiotic-associated diarrhea was caused.

[0028] (2) Effect of pectin on body weight of rats with antibiotic-associated diarrhea:

[0029] SD rats are divided into 5 groups according to the method of random grouping, namely, blank control group, clindamycin diarrhea control group, 1.0% (embodiment 1), 1.5% (embodiment 1), 2.0% (embo...

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Abstract

The invention discloses a preparation method for a pectin solution for treating antibiotic associated diarrhea. The method comprises the following steps: dissolving amidate low-methoxy pectin into 0.05+ / -0.01mol / L sodium chloride at solid liquid ratio of 10-20g / 100ml and then cooking for 10-15 minutes at 100+ / -5 DEG C, thereby acquiring the pectin solution for treating antibiotic associated diarrhea. The invention also discloses the pectin solution for treating antibiotic associated diarrhea prepared according to the method.

Description

technical field [0001] The invention relates to a pectin solution for treating antibiotic-associated diarrhea (AAD) and a preparation method thereof. Background technique [0002] Unreasonable use of antibiotics or long-term, large-scale use will lead to related side effects. Antibiotic-associated diarrhea (AAD) is a common complication of antibiotic application, the most common iatrogenic diarrhea, and one of the adverse reactions of many antibiotics. According to clinical reports, the incidence of AAD is 5%-62%, and the incidence of ICU patients is even higher. Once it occurs, it will aggravate the patient's condition, increase the difficulty of treatment, and even endanger the patient's life. The pathogenesis of AAD has a non-negligible relationship with broad-spectrum antibiotics and the combined use of multiple antibiotics. Common treatment methods include stopping antibiotics, using targeted antibiotics, nutritional support, improving immunity, and adjusting intestin...

Claims

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Application Information

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IPC IPC(8): A61K31/732A61K9/08A61P1/12
CPCA61K9/0095A61K31/732A61K47/02
Inventor 沈生荣于海宁张司晨李民锋谭桂薇
Owner ZHEJIANG UNIV