Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A double nano-drug loading system containing apog2 and alpcs4 and its preparation method and application

A technology of nano-drug loading and nano-micelle, applied in the field of anti-tumor drug research

Active Publication Date: 2020-07-28
XI AN JIAOTONG UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no dual-drug system constructed with AlpcS4 and ApoG2 in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A double nano-drug loading system containing apog2 and alpcs4 and its preparation method and application
  • A double nano-drug loading system containing apog2 and alpcs4 and its preparation method and application
  • A double nano-drug loading system containing apog2 and alpcs4 and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0032] 1. Preparation of double nano drug loading system:

[0033] Weigh 10mg of F-127 and dissolve in 1ml of absolute ethanol, then dissolve 2.5mg, 2.5mg, and 5mg of ApoG2 in the absolute ethanol solution of F-127 for later use. Weigh 2.5mg, 2.5mg, 5mg of AlpcS4, dissolve in 10ml of deionized water and stir on a magnetic stirrer. Then, the F-127 ethanol solution containing 2.5 mg, 5 mg, and 2.5 mg of ApoG2 was slowly added dropwise to the corresponding deionized water of AlpcS4, and stirred for 24 hours. The specific reaction mode is shown in Table 1. Then it was placed in a dialysis bag for purification for 24 hours, during which the water was changed about 8 times. After the end, it was collected in a 10cm culture plate and freeze-dried at -20°C, and finally freeze-dried to obtain the F-1...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention provides a double nanoparticle drug carrier system containing ApoG2 and AlpcS4. The double nanoparticle drug carrier system is prepared from the following components in parts by weight: 1 to 2 parts of ApoG2, 1 to 2 parts of AlpcS4 and 3 to 5 parts of poloxamer, wherein the ApoG2 and the AlpcS4 are encapsulated in the poloxame. According to the double nanoparticle drug carrier system containing the ApoG2 and the AlpcS4, synergistic inactivation of tumor cells by photodynamic therapy of an AlpcS4 photosensitizer and an ApoG2 chemotherapeutic drug can be realized; in addition, the problem of insolubility of the AlpcS4 is effectively solved. The preparation method is simple. The invention further provides a preparation method of the double nanoparticle drug carrier system containing the ApoG2 and the AlpcS4 and application of the double nanoparticle drug carrier system in preparing an antitumor drug.

Description

technical field [0001] The invention relates to the field of antitumor drug research, in particular to a double-nano drug-carrying system containing ApoG2 and AlpcS4, a preparation method and application thereof. Background technique [0002] According to the World Health Organization's 2014 global cancer report, there are 14 million new cases and 8 million deaths worldwide every year. Therefore, malignant tumors seriously endanger human life and health. Among them, gastric cancer is the third most common tumor in my country, with an annual new incidence rate of more than 400,000 and a death rate of more than 300,000, ranking first in the world. According to statistics, more than 40% of new gastric cancers in the world occur in China every year, while the incidence rate in western countries is relatively low, so it has become one of the major diseases that our country must overcome independently. In recent years, the basic research and clinical treatment of gastric cancer ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/107A61K47/10A61P35/00B82Y5/00A61K31/122
CPCA61K9/1075A61K31/122A61K41/0071A61K47/10B82Y5/00A61K2300/00
Inventor 辛静张镇西姚翠萍王兵王晶王斯佳张璐薇
Owner XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com