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Novel application of fibrinogen gamma chain and kit

A technology of fibrinogen and kit, which is applied in the field of new uses of fibrinogen gamma chain and kits, and can solve problems such as communication barriers and misjudgment of TBI conditions

Active Publication Date: 2017-12-22
唐颐生物医学(天津)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, TBI is often accompanied by multiple injuries, resulting in eye opening, language and movement disorders that may not be related to TBI, leading to misjudgment of the condition of TBI
In addition, the languages ​​of different countries and regions may also have certain communication barriers

Method used

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  • Novel application of fibrinogen gamma chain and kit
  • Novel application of fibrinogen gamma chain and kit
  • Novel application of fibrinogen gamma chain and kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 A kind of test kit for detecting or assessing TBI patient's injury condition

[0030] The kit includes a substance for detecting fibrinogen gamma chain, and the substance for detecting fibrinogen gamma chain is an antibody against fibrinogen gamma chain.

Embodiment 2

[0031] Embodiment 2 A kind of test kit for detecting or assessing TBI patient's injury condition

[0032] The kit includes anti-fibrinogen γ-chain antibody, anti-plate, standard, buffer, anti-fibrinogen γ-chain antibody diluent, washing solution, stop solution;

[0033] Wherein, the fibrinogen γ-chain antibody diluent is a phosphate buffer solution containing 0.1% ethylene oxide, 1.5% heparin sodium, and 3.4% dextran in a mass fraction, and the concentration of the phosphate buffer solution is 1mol / L.

Embodiment 3

[0034] Embodiment 3 A kind of test kit for detecting or assessing TBI patient's injury condition

[0035] The kit includes anti-fibrinogen γ-chain antibody, anti-plate, standard, buffer, anti-fibrinogen γ-chain antibody diluent, washing solution, stop solution;

[0036] Wherein, the fibrinogen γ-chain antibody diluent is a phosphate buffer solution containing 0.1% ethylene oxide, 1.5% heparin sodium, and 3.4% dextran in a mass fraction, and the concentration of the phosphate buffer solution is 1mol / L;

[0037] The washing solution is a phosphate buffer solution containing mass fraction of 3% chitosan and 0.5% cholesterol palmitate, and the concentration of the phosphate buffer solution is 0.2mol / L;

[0038] As a further improvement, the stop solution is 0.2 mol / L hydrochloric acid aqueous solution.

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Abstract

The invention provides novel application of a fibrinogen gamma chain and a kit. A substance for detecting the fibrinogen gamma chain can be applied to assessment of the injury condition of a TBI (traumatic brain injury) patient or detection and auxiliary detection of the severity of the injury condition of the TBI patient to be assessed; when a method is used for assessing or detecting the severity of the injury condition of the TBI patient, the method has the advantages of high specificity, high sensitivity, high reproducibility, high patient compliance and the like; in addition, tests prove that the fibrinogen gamma chain can be used as a marker for assessing the severity of the injury condition of the TBI patient, a result is accurate, operation is simple and convenient, and a very high application value is achieved.

Description

technical field [0001] The invention belongs to the application field of fibrinogen gamma chain, in particular to a new application and kit of fibrinogen gamma chain. Background technique [0002] Traumatic Brain Injury (TBI) is an important factor affecting human health in the world. Because it can occur in occasions closely related to human life, such as traffic accidents, work, and sports, it has a very high incidence rate. Recent statistics show that 2 million TBIs occur each year in the United States, and 43% of TBI patients will be left with disabilities. According to statistics, 1 million TBIs occur every year in China, and according to Chinese head trauma data (Chinese Head Trauma Data Bank, CHTDB), the mortality rate of TBI patients can reach 21.8%. [0003] According to the degree of injury, TBI can be divided into mild, moderate and severe TBI. The classification method is mainly based on the Glasgow Coma Scale (GCS), that is, in TBI, patients with a GCS score ...

Claims

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Application Information

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IPC IPC(8): G01N33/533G01N33/558
CPCG01N33/533G01N33/558
Inventor 程世翔张赛徐忠伟衣泰龙曹毓琳
Owner 唐颐生物医学(天津)有限公司