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Rapid detection method and detection kit for detecting morphine and codeine in hot pot food

A detection method and a kit technology, which are applied in the direction of material analysis by observing the influence of chemical indicators, and analysis by causing materials to undergo chemical reactions, can solve the problems of long inspection time, shortage, cumbersome operation, etc., and achieve detection The effect of short time, elimination of interference, and simple operation

Inactive Publication Date: 2017-12-26
广东省药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above methods are cumbersome to operate and take a long time to test, and are not suitable for the requirements of on-site rapid testing by supervision departments and testing institutions.
At present, the extraction methods of morphine and codeine in hot pot food are complicated, and the commercially available detection kits lack matching extraction reagents, and a few have matching diluents, which only dilute the samples, and the extraction effect on solids and semi-solids is not good. , it cannot detect strong acidic seasonings such as vinegar, and cannot meet the detection needs of seasonings with various matrices in the market

Method used

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  • Rapid detection method and detection kit for detecting morphine and codeine in hot pot food

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, the rapid detection kit of morphine, codeine in chafing dish food

[0026] The rapid detection kit for morphine and codeine in hot pot food contains sample extraction solution, sodium bicarbonate powder, morphine and codeine detection card; the sample extraction solution is 0.1mol / L hydrochloric acid solution.

Embodiment 2

[0027] Example 2, the rapid detection method of morphine and codeine in hot pot food

[0028] The rapid detection method of morphine and codeine in hot pot food comprises the following steps:

[0029] (1) Prepare 0.1mol / L hydrochloric acid solution as sample extract;

[0030] (2) For liquid hot pot food, take 1g sample and add 4mL sample extract; for solid and semi-solid hot pot food, take 1g sample and add 5mL sample extract; shake vigorously for 5-10 minutes to mix;

[0031] (3) According to the volume-to-mass ratio of the mixed solution to sodium bicarbonate: 10 mL: add 1 g of sodium bicarbonate powder, shake for 5 to 10 minutes until no more bubbles emerge, and let stand for 1 to 2 minutes to obtain the test solution;

[0032] (4) Take out the aqueous layer solution of the liquid to be tested, add 4 to 5 drops to the sample holes of the morphine and codeine test cards, operate and interpret the results according to the instructions of the morphine and codeine test cards: ...

Embodiment 3

[0037] Embodiment 3, the sensitivity of detection method of the present invention

[0038] Accurately weigh 5.0mg each of morphine and codeine reference substances, dissolve them in methanol to 5mL, and obtain 1mg / mL single-label stock solution; weigh 1g of solid, semi-solid, and liquid chafing dish respectively in sample tubes, each in parallel Get 11 parts, respectively add different concentrations of morphine, codeine single-label stock solution, obtain solid, semi-solid and liquid samples containing morphine, codeine; extract and detect according to the method of embodiment 2, draw the detection method of the present invention The detection limit of the method was 40 μg / kg.

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Abstract

The invention discloses a rapid detection method and a detection kit for detecting morphine and codeine in a hot pot food. According to the method, a sample extract and sodium bicarbonate are used to process a hot pot food, morphine and codeine in the hot pot food can be extracted effectively, and the extracted morphine and codeine can be directly detected by a morphine and codeine detection card. The detection limit of the detection method is 40 [mu]g / kg. The detection accuracy is 98% and the specificity is 97%. The interference of other alkaloids and other matrixes in the hot pot food can be eliminated. The operation is simple, the detection time is short, and the detection method does not need any special equipment, is suitable for onsite detection, and meets the onsite detection requirements of surveillance departments, detection departments, and various organizations.

Description

technical field [0001] The invention relates to the field of food detection, more specifically, to a rapid detection method and detection kit for morphine and codeine in hot pot food. Background technique [0002] Poppy husks, commonly known as smoke husks, are the dried and mature husks of poppy plants in the family Papaveraceae after cutting the juice. They contain more than 20 kinds of alkaloids, among which the most abundant alkaloids are morphine, codeine, thebaine, and opium poppy. Alkali, Nascotine. Poppy husk has the effects of astringing the lungs, astringing the intestines, and relieving pain, and has certain medicinal value. It is recorded in the "Chinese Pharmacopoeia" as a traditional Chinese medicinal material. The alkaloids in the poppy shell can make people drowsy and change their personality, causing a certain degree of comfort and euphoria, which can cause the decline of people's attention, thinking and memory performance. Long-term consumption can cause m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78
CPCG01N21/78
Inventor 刘丛丛刘亚雄温家欣何嘉雯赖宇红王炳志
Owner 广东省药品检验所
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