A kind of chitosan nano microbubble and its preparation method and application
A chitosan nano and chitosan technology is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Poor and other problems
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Embodiment 1
[0052] A preparation method of chitosan nano microbubbles, comprising the steps of:
[0053](1) Prepare 50 mL of acrylic acid aqueous solution with a mass concentration of 0.44%, add chitosan, the chitosan mass (unit g) added is 1% of the volume (unit mL) of the acrylic acid aqueous solution, stir until completely dissolved, and heat under nitrogen protection To 75°C, add 70 mg of potassium persulfate, react for about 1 hour, set the temperature to 60°C, continue the reaction for 80 minutes, then filter the product to remove impurities, then pour it into a dialysis bag, and then place it in acetic acid with pH=4.5- In sodium acetate buffer solution, magnetically stirred for 24 hours, dialyzed to remove impurities, then taken out, added 0.078g of glutaraldehyde, heated to 40°C for reaction, after 2 hours, the reaction was completed, and a nanoparticle suspension was prepared, with a particle size of about 100nm , and has a hollow structure, its shape is observed by transmission...
Embodiment 2
[0056] A preparation method of chitosan nano microbubbles, comprising the steps of:
[0057] (1) Prepare 50 mL of an acrylic acid solution with a mass concentration of 0.22%, add chitosan, the chitosan mass (unit g) added is 0.5% of the volume (unit mL) of the acrylic acid aqueous solution, stir until completely dissolved, and heat under nitrogen protection To 75°C, add 45 mg of potassium persulfate, react for about 1 hour, set the temperature to 60°C, after 100 minutes, filter the product to remove impurities, then pour it into a dialysis bag, and place it in acetic acid-sodium acetate buffer at pH=4.5 In the liquid, take it out after magnetic stirring for 24 hours, add 0.035g of glutaraldehyde, and heat to 40°C for reaction. After 2 hours, the reaction is completed, and the nanoparticle suspension is obtained. The particle size of the nanoparticle is about 100nm and has a hollow structure. form and figure 1 similar.
[0058] (2) Add lactose to the nanoparticle suspension p...
Embodiment 3
[0060] A preparation method of chitosan nano microbubbles, comprising the steps of:
[0061] (1) Prepare 50 mL of acrylic acid solution with a mass concentration of 0.44%, add chitosan, the quality of chitosan added (in g) is 1% of the volume of acrylic acid aqueous solution (in mL), heat to 70°C under nitrogen protection, add 60mg of potassium persulfate, react for about 1 hour, set the temperature to 60°C, filter the product after 80 minutes to remove impurities, then pour it into a dialysis bag, put it in acetic acid-sodium acetate buffer solution with pH=4.5, and stir it magnetically for 24 hours Take it out, add 0.078g of glutaraldehyde, heat to 40°C for reaction, after 2h, the reaction is complete, and a nanoparticle suspension is obtained. The particle size of the nanoparticle is about 100nm and has a hollow structure. figure 1 similar.
[0062] (2) Add mannitol to the nanoparticle suspension prepared in step (1), the quality (unit g) of mannitol is 5% of the volume (u...
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