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Gadolinium-doped hollow vesicle structure nanocomposite, and preparation and application thereof

A technology of nanocomposite materials and vesicle structure, which is applied in the field of composite materials, and can solve the problems of limited application, difficulty in controlling the particle size of microspheres by soft template method, etc.

Inactive Publication Date: 2016-08-31
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the soft template method is not easy to control the particle size of the microspheres, which limits the application of this method.

Method used

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  • Gadolinium-doped hollow vesicle structure nanocomposite, and preparation and application thereof
  • Gadolinium-doped hollow vesicle structure nanocomposite, and preparation and application thereof
  • Gadolinium-doped hollow vesicle structure nanocomposite, and preparation and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] A nanocomposite material with gadolinium-doped hollow vesicle structure, the composite material is based on gadolinium-doped silica hollow vesicles, and the surface of the main body is modified with dihydroxysilyl phthalocyanine and polyethylene glycol with silane , in the main body, the ratio of the molar number of gadolinium to the mass of silicon dioxide is 1mol:100g, the main body is in the shape of a vesicle, and the particle size of the composite material is 130-250nm. The weight ratio of host, dihydroxysilyl phthalocyanine and polyethylene glycol with silane is 40:1.33:46.55 (ie 30:1:35).

[0048] The preparation process of the gadolinium-doped hollow vesicle nanocomposite is as follows: figure 1 As shown, it specifically includes the following steps:

[0049] (1) Preparation of solid SiO 2 : Mix 50mL ethanol and 5mL ammonia water evenly; add 5mL tetraethyl orthosilicate dropwise into the mixture, stir for a certain period of time, and the reaction ends; wash 5...

Embodiment 2

[0057] Add 50 μL of 9,10 dimethylanthracene (DMA) dropwise to 4 mL of the HS-Gd-SPCD / PEG solution prepared in Example 1, HS-Gd-SPCD / PEG is dispersed in ethanol: water = 4:1 mixed solvent. The mixed solution was irradiated with a 660nm laser, and the fluorescence of the solution was detected every 5 minutes. The fluorescence excitation wavelength is 360nm, and the emission wavelength is 380-550nm. Cyclic detection for 1h is used to test the generation of singlet oxygen. Test results such as Figure 7 As shown, the decreasing trend of the fluorescence intensity of DMA presents regular changes, indicating that SPCD can generate singlet oxygen under 660nm excitation.

Embodiment 3

[0059] The HS-Gd-SPCD / PEG prepared in Example 1 was formulated into different concentrations, respectively 0 μg / mL, 10 μg / mL, 50 μg / mL, 100 μg / mL, 200 μg / mL, 400 μg / mL and 650 μg / mL, Under the same probe frequency and different mechanical index conditions, the effect of HS-Gd-SPCD / PEG vesicle solution on contrast-enhanced ultrasound in vitro was tested. The results are as follows: Figure 8 As shown, the results show that at the same concentration, the greater the mechanical index, the better the contrast effect. When the mechanical index is the same, within a certain concentration range, the greater the concentration, the better the contrast effect. However, when a resonance saturation threshold is reached, the concentration increases, which will make the contrast effect worse.

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Abstract

The invention relates to a gadolinium-doped hollow vesicle structure nanocomposite. The nanocomposite uses a gadolinium-doped silica hollow vesicle as a main body; the surface of the main body is modified with a photosensitizer and polyethylene glycol with silane; in the main body, a ratio of the mole number of gadolinium to the mass of silica is (0.8 to 1.5) mmol: (80-120) mg; and a weight ratio of the main body to the photosensitizer to polyethylene glycol with silane is (40-50): (0.5-1.6): (30-50). Gadolinium acetate is used as an etching agent, solid silica microspheres are used as a silicon source and hard template, CO2 produced by acetate at high temperature is used as a soft template, and hollow vesicle microspheres are synthesized in one step; then the hollow vesicle microspheres are modified with the photosensitizer so as to allow the nanocomposite to have photodynamic and photo-thermal properties; and the nanocomposite is used for preparation of a contrast agent or a functional material with photodynamic and photo-thermal treatment effect. Compared with the prior art, the nanocomposite provided by the invention is convenient to synthesize, exerts obvious effect in MR and ultrasonic imaging, and has photodynamic and photo-thermal treatment effect; so the nanocomposite has good development prospects in integrated diagnosis and treatment application.

Description

technical field [0001] The invention relates to the technical field of composite materials, in particular to a nanocomposite material with a hollow vesicle structure doped with gadolinium and its preparation and application. Background technique [0002] Silica hollow microspheres are a class of materials with a unique shape: controllable particle size, large specific surface area, low density, and good stability. Because of its hollow interior, it can encapsulate gas or small molecular substances, and at the same time, it can also encapsulate compounds with special functions; therefore, it can be applied to controlled drug release; water pollution treatment; chemical catalysis; biochemistry, etc. [0003] At present, the methods for preparing hollow silica microspheres are mainly template methods: hard template method and soft template method. The template material of the hard template method is easier to remove; the size of the cavity can be controlled and adjusted accord...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/10A61K49/18A61K49/22A61K41/00C08G83/00
CPCA61K41/0052A61K41/0071A61K49/101A61K49/1812A61K49/223C08G83/001
Inventor 吴惠霞郭琳琳王研科常旭宗路艳杨仕平
Owner SHANGHAI NORMAL UNIVERSITY
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