Pharmaceutical composition for treating hepatitis, pharmaceutical preparation as well as application and preparation method thereof

A composition and medicine technology, applied in the field of pharmaceutical preparations for treating hepatitis, can solve the problems of unclear active ingredients and their mechanism of action, large dosage and the like

Active Publication Date: 2018-01-12
GUIZHOU RUIHE PHARMA CO LTD LONGLI PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to overcome the shortcomings of the existing Jinmagantai capsule preparations, which are large in dosage, active ingredients and their mechanism of action are not clear, and provide a fast, safe and quality-controllable treatment for liver and gallbladder damp-heat, stagnation of qi Medicine composition for acute and chronic hepatitis caused by blood stasis and preparation method thereof

Method used

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  • Pharmaceutical composition for treating hepatitis, pharmaceutical preparation as well as application and preparation method thereof
  • Pharmaceutical composition for treating hepatitis, pharmaceutical preparation as well as application and preparation method thereof
  • Pharmaceutical composition for treating hepatitis, pharmaceutical preparation as well as application and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the preparation that has sugar type tablet

[0046] Take 8.45g of total flavonoids of horseshoe gold, 2.56g of quercetin, 1.91g of verbenin, 8.96g of tetrandrine, 7.62g of tetrandrine, 1.42g of hedera saponin, 2.82g of icariin, and 0.70g of astragaloside g, 15.76g of paeoniflorin, 5.54g of tanshinone IIA, 4.15g of cryptotanshinone, add 12 times of 75% ethanol solution, stir and dissolve, place for 48h, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.37 (55°C) thick paste, add 32% starch and 1.3% microcrystalline cellulose, granulate, dry at 60°C, add 0.1% magnesium stearate, mix, tablet, film-coat, 1000 tablets were prepared, each with about 59.98 mg of active ingredient.

Embodiment 2

[0047] Embodiment 2: Preparation of sugar-free granules

[0048] Take 7.82g of total flavonoids of horseshoe gold, 2.37g of quercetin, 1.66g of verbenin, 6.51g of tetrandrine, 6.06g of tetrandrine, 1.20g of hedera saponin, 2.56g of icariin, and 0.62g of astragaloside g, paeoniflorin 14.30g, tanshinone ⅡA 4.83g, cryptotanshinone 3.42g, add 10 times of 70% ethanol solution, stir and dissolve, let stand for 48h, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.34 (50°C) Add 60% dextrin to make sugar-free granules, spray 80ml of 2% hydroxypropyl methylcellulose ethanol solution into granules after the granules are formed, and make 1000 bags of granules, each bag Active ingredient approx. 51.35 mg.

Embodiment 3

[0049] Embodiment 3: the preparation of capsule

[0050] Take 9.00g of total flavonoids of horseshoe gold, 2.71g of quercetin, 2.15g of verbenin, 6.51g of tetrandrine, 9.83g of tetrandrine, 1.20g of hedera saponin, 3.17g of icariin, and 0.62g of astragaloside g, paeoniflorin 17.88g, tanshinone ⅡA 4.83g, cryptotanshinone 4.68g, add 10 times of 80% ethanol solution, stir and dissolve, put it aside for 48h, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.34 (60°C) The thick paste is dried at 60° C., pulverized, added with 0.5% magnesium stearate, mixed evenly, and packed into capsules to obtain 1000 capsules, each with about 62.58 mg of active ingredient.

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Abstract

The invention relates to a pharmaceutical composition for treating hepatitis, a pharmaceutical preparation as well as an application and a preparation method thereof and belongs to the technical fieldof pharmaceutical preparations for treating hepatitis. The pharmaceutical composition preparation comprises the following components in parts by weight: 7.82-9.00 parts of creeping dichondra monomer,2.37-2.71 parts of berchemia lineata monomer, 1.66-2.15 parts of verbena monomer, 12.57-20.36 parts of radix stephaniae tetrandrae monomer, 1.20-1.74 parts of patrinia monomer, 2.56-3.17 parts of herba epimedii monomer, 0.62-0.77 part of astragalus monomer, 14.30-17.88 parts of red paeony root and 8.25-11.02 parts of salvia miltiorrhiza monomer. The previous medicinal monomers are selected, the auxiliary materials are added, and the pharmaceutical preparation prepared according to the conventional preparation process is applied to treating acute and chronic hepatitis caused by liver-gallbladder dampness-heat and qi-stagnation and blood stasis, achieves unexpected treatment effects, has low toxicity while treating hepatitis and is an ideal medicine.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations for treating hepatitis, in particular to a pharmaceutical composition, pharmaceutical preparation, application and preparation method for treating hepatitis. Background technique [0002] According to the severity of the disease, hepatitis can be divided into common hepatitis and severe hepatitis; according to the length of the disease, it can be divided into acute hepatitis and chronic hepatitis. This disease belongs to the category of syndromes such as "jaundice", "rib pain", "fever yellow" and "urgent yellow" in traditional Chinese medicine. From the perspective of etiology of traditional Chinese medicine, damp heat is the basic cause of disease of this disease, and runs through the course of the disease from beginning to end. [0003] "Jinmagantai Capsule" is a preparation made of horseshoe gold as the main ingredient, produced by Guizhou Better Pharmaceutical Co., Ltd., a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/39A61P1/16A61K31/352A61K31/7048A61K31/4748A61K31/704A61K31/58
Inventor 薛捷张禄权李白玲毛玉莲李辉何容
Owner GUIZHOU RUIHE PHARMA CO LTD LONGLI PHARMA FACTORY
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