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Pharmaceutical compound preparation for treating reflux esophagitis

A technology of reflux esophagitis and compound preparations, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve serious complications and other problems, achieve less sequelae, significant therapeutic effect, and convenient administration Effect

Inactive Publication Date: 2018-01-16
CHENGDU LINGXI SHANGPIN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing treatment methods are all through the injection of antibacterial drugs, and then observe the patient's condition, and do further treatment according to the patient's condition. Generally, they are accompanied by relatively serious complications. At present, there is no better way to treat this condition

Method used

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  • Pharmaceutical compound preparation for treating reflux esophagitis
  • Pharmaceutical compound preparation for treating reflux esophagitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The compound oral preparation of this embodiment is prepared by known methods in the pharmaceutical industry, and the specific consumption of each component is shown in Table 1:

[0026] Table 1 Specific dosage of each component

[0027]

[0028]

[0029] The therapeutic effect of using cisapride and famotidine in combination with two oral drugs shows that the effect of using cisapride and famotidine is better than that of using a single drug, so as to develop a rational combination of the two drugs The compound preparations laid the foundation.

Embodiment 2

[0031] Validation of the therapeutic effect of the rat model:

[0032] Objective: To observe the effect of cisapride combined with famotidine in different proportions of compound preparations on DOCA (desoxycorticosterone acetate) in rats with reflux esophagitis, in order to explore the therapeutic effect of compound preparations with different doses .

[0033] Methods: 1200 SD rats, ♂, weighing 180-190 g. After the right kidney was excised under sterile conditions, DOCA 5 mg per animal was given twice a week, sc, and fed with 1% sodium chloride solution; they were randomly divided into 12 groups, with 8 mice in each group. The specific grouping and treatment are shown in the table. two.

[0034] Table 2 Animal grouping, drug formula and administration method

[0035] model group

normal saline

cisapride group

Cisapride 400 mg

famotidine high group

Famotidine 40 mg

Compound group

Cisapride 20mg, Famotidine 2mg

Compound two...

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Abstract

The invention discloses a pharmaceutical compound preparation for treating reflux esophagitis. The compound preparation comprises the following components in parts by weight: 10 to 300 parts of cisapride, 10 to 120 parts of famotidine, and 10 to 1600 parts of drug carrier. Cisapride and famotidine are taken as the pharmaceutical components and mixed with the drug carrier to prepare the compound preparation. The compound preparation is convenient to take, is very safe, has a prominent effect, can greatly reduce complications, generates few sequelae, barely causes adverse reactions, and promotesthe healing.

Description

technical field [0001] The invention relates to the field of drug compound preparations, in particular to a drug compound preparation for treating reflux esophagitis. Background technique [0002] Reflux esophagitis refers to the inflammation, erosion, ulceration and fibrosis of the esophageal mucosa caused by the reflux of stomach and (or) duodenal contents into the esophagus, which belongs to gastroesophageal reflux disease. [0003] "Heartburn" is a typical symptom of reflux, usually a burning discomfort after the breastbone, which usually occurs after meals, especially after a full meal. The reflux material is sour or bitter, occasionally containing a small amount. It can also occur at night, and is often disturbed when asleep. Relief or disappear after taking antacids. Swallowing pain and dysphagia are manifestations of aggravated reflux. At this time, attention should be paid to whether there is an esophageal ulcer. The pain can involve the subxiphoid process, the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445A61P1/04A61K31/426
Inventor 姜迪蛟
Owner CHENGDU LINGXI SHANGPIN TECH CO LTD
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