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Uric acid-lowering composition

A composition and uric acid-lowering technology, which is applied in the direction of drug combination, plant raw materials, plant/algae/fungus/moss components, etc., can solve the problems of easy recurrence of pain, serious side effects, and no uric acid-lowering composition. Achieve the effect of high marketing value, high safety, and obvious effect of lowering uric acid

Active Publication Date: 2018-01-16
云南彝药生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the treatment of gout, western medicines are mostly used at present. The commonly used ones are colchicine, non-steroidal anti-inflammatory analgesics, adrenal corticosteroids and probenecid. , the pain is easy to recur after stopping the drug, and these drugs often have relatively large toxic and side effects. In addition to causing gastrointestinal reactions, long-term use may also lead to bone marrow suppression, liver cell damage, mental depression, ascending paralysis, and respiratory depression. Wait for side effects
[0005] At present, there is no uric acid-lowering composition prepared from mango, Dianzizao, cherry, and Poria as raw materials, and the compound Tuse Tuxi (by Maiji), Tearbu, Kuanjinteng, Duopizhai, Tuabu, A report on the preparation of uric acid-lowering products by Luomuya and other Yi medicines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: This uric acid-lowering composition is prepared from the following components: 200g of mango, 80g of Rhizoma Dianzi, 90g of cherry, and 80g of Poria cocos; each component is pulverized and mixed, and then prepared into tablets after adding auxiliary materials according to the conventional preparation method ;

[0024] In order to verify the uric acid-lowering effect of the composition of this embodiment, a comparison test study on the reduction of hyperuricemia by the composition was carried out:

[0025] Male Kunming mice were divided into control group and hyperuricemia group [intraperitoneal injection of oxonic acid potassium salt method (300mg / kg

[0026] One-time intraperitoneal injection) to prepare hyperuricemia animal model], hyperuricemia group was randomly divided into model group,

[0027] The allopurinol (40mg / kg) treatment group, the composition treatment group, the composition treatment group were gavaged with the composition of this embodiment...

Embodiment 2

[0031] Example 2: This uric acid-lowering composition is prepared from the following components: 200g of mango, 80g of Dianzizao, 90g of cherry, and 80g of Poria cocos;

[0032] The preparation method of the uric acid-reducing composition of the present embodiment is as follows:

[0033] Weigh the raw materials in proportion, then use the hot water reflux extraction method to extract the mangoes, Dianzizao, cherries, and poria cocos respectively, the mass-to-volume ratio of the extraction material to liquid g:mL is 1:18, and the single extraction time is 1 hour, and the extraction is performed 3 times. The extraction temperature is 70°C. After the extraction, the supernatant is concentrated, dried and powdered to obtain the corresponding extract, and the above extracts are mixed to obtain the uric acid-lowering composition;

[0034] In order to verify the uric acid-lowering effect of the composition of this example, a comparative test study on the reduction of hyperuricemia by...

Embodiment 3

[0038] Example 3: This uric acid-lowering composition is prepared from the following compositions: 100g of mango, 140g of Dianzizao, 50g of cherry, 40g of Poria, 100g of Tuxi, 130g of Tearbu, 30g of Jituoqi, 250g of Duopizhai, Soil astringent 120g, Luomuya 20g;

[0039] The preparation method of the uric acid-reducing composition of the present embodiment is as follows:

[0040] (1) Tuse Tuxi (by Maiji), Kuanjinteng, Duopizhai, and Luomuya were extracted by traditional ethanol heat reflux extraction method, the mass-volume ratio of extraction material to liquid g:mL was 1:12, and the extraction solution The ethanol concentration is 70%, the single extraction time is 1 hour, the extraction is 3 times, and the extraction temperature is 55°C. After the extraction is completed, the supernatant is recovered from the ethanol, concentrated, dried and sprayed with powder to obtain the corresponding extract;

[0041] (2) The traditional hot water reflux extraction method was used for ...

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Abstract

The invention discloses a uric acid-lowering composition, which is composed of, by weight, 8-22 parts of mango, 5-14 parts of Yunnan Hovenia Thunb., 4-9 parts of cherry and 3-8 parts of Poria cocos. The composition has effects of neutralizing excessive acidic substances, regulating acid-base balance of body, promoting uric acid excretion, reducing uric acid level of serum and preventing renal lesions, metabolic diseases and cardiovascular disease caused by high uric acid content, and is suitable for those who suffer from gout, obesity, lithangiuria, ''three high''(hypertension, hyperglycemia and hyperlipemia) and the like. The preparation technology is simple and feasible, and is suitable for industrial production and market promotion and application.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine production, in particular to a uric acid-lowering composition. Background technique [0002] Gout is a group of metabolic diseases caused by excessive uric acid or decreased excretion of uric acid caused by the disorder of purine metabolism in the body, and accumulates and precipitates in the body. With the improvement of people's living standards and changes in diet structure, the incidence of gout is increasing year by year. According to conservative estimates, there are currently 120 million patients with hyperuricemia in my country, accounting for nearly 10% of the total population. Among them, the sales growth rate of anti-gout drugs in hospitals in key cities such as Beijing, Shanghai, Guangzhou, and Shenzhen has remained above 30% almost every year. [0003] The endogenous production of uric acid accounts for about 80%, and the exogenous production accounts for about 2...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K36/90A61K36/896A61P19/06
Inventor 焦少良付翠花潘杰陈之芳
Owner 云南彝药生物科技有限公司
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