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Fermented small molecule peptide mixed liquid with uric acid reducing effect and preparation method and application thereof

A small-molecule peptide, fermented technology, which is applied in the field of fermented small-molecule peptide mixture and its preparation, can solve the problems of treating gout, such as difficult, single action, etc., to achieve obvious effect, wide range of action, and less side effects

Pending Publication Date: 2021-07-23
JILIN PROVINCE TEYIFOOD BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although western medicine can temporarily relieve the symptoms of hyperuricemia and reduce blood uric acid, its single effect makes it difficult to treat gout fundamentally, and long-term use of such western medicine has great side effects on the human body

Method used

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  • Fermented small molecule peptide mixed liquid with uric acid reducing effect and preparation method and application thereof
  • Fermented small molecule peptide mixed liquid with uric acid reducing effect and preparation method and application thereof
  • Fermented small molecule peptide mixed liquid with uric acid reducing effect and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0026] The invention provides a method for preparing a fermented small molecule peptide mixture with the effect of reducing uric acid, comprising the following steps:

[0027] Mixing Cordyceps militaris and water according to the mass ratio (15-20): (150-200) to obtain the bacterial liquid;

[0028] After mixing the composite raw material with the bacterial liquid, carry out compound probiotic fermentation, enzymolyze and ultrafilter the obtained fermented liquid sequentially, cut off molecular peptides with a molecular weight of 300-2000 Da, and obtain a fermented small molecular peptide mixed liquid; the composite raw material It includes Poria cocos, chicory, white-backed notoginseng, coix seed rice bran, sophora japonica, gardenia, lotus and sunflower dish; the mass ratio of the compound raw material and bacterial liquid mixed is (90-150):(150-200);

[0029] The enzymatic hydrolysis includes first enzymatic hydrolysis using cellulase, second enzymatic hydrolysis using pect...

Embodiment 1

[0048] After crushing 30g of Cordyceps militaris, mix it with 300ml of water, and measure 300ml of bacterial liquid; wherein the particle size of Cordyceps militaris after crushing is 1cm;

[0049] 10 parts by mass of Poria (20g), 15 parts by mass of chicory (30g), 10 parts by mass of Panax notoginseng (20g), 10 parts by mass of barley bran (20g), 10 parts by mass of Sophora japonica (20g), 10 parts by mass of 15 parts by mass of gardenia (20g), 10 parts by mass of lotus leaf (20g) and 15 parts by mass of sunflower disc (30g) were mixed with 150 parts by mass (300ml) of bacterial liquid, and compounded probiotics were carried out at room temperature at 27°C and below humidity 70wt.%. Powder (compound probiotic powder is Bifidobacterium adolescentis, Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus casei and Lactobacillus rhamnosus, purchased from Shandong Junle Biotechnology Co., Ltd.) fermented for 24 hours , to obtain a fermented liqui...

Embodiment 2

[0058] The same as the experimental procedure of Example 1, the difference is that 170 parts by mass of Cordyceps militaris bacterium liquid (340ml), 12 parts by mass of Poria cocos (24g), 16 parts by mass of chicory (32g), 13 parts by mass of Radix Notoginseng (26g ), 14 mass parts barley rice bran (28g), 15 mass parts Sophora japonica (30g), 13 mass parts gardenia (26g), 11 mass parts lotus leaf (22g) and 19 mass parts sunflower dish (19g), get 28 parts by mass of fermented small molecule peptide mixture (56ml).

[0059] After the end of the 15th day, the blood uric acid value was measured, and the results are shown in Table 2.

[0060] Table 2 blood uric acid survey data (μmol / L)

[0061] Before modeling After modeling after administration blank group 174.28±17.21 176.60±13.31 180.60±11.60 model group 183.21±11.19 389.00±12.18 374.74±12.38 G 180.68±11.31 393.59±17.01 197.87±16.11*

[0062] Compared with the model group, *P<0.01 ...

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Abstract

The invention relates to the field of small molecule peptide mixed liquid extraction, and particularly relates to fermented small molecule peptide mixed liquid with a uric acid reducing effect and a preparation method and application thereof. The preparation method of the fermented small molecule peptide mixed liquid with the uric acid reducing effect comprises the following steps that cordyceps militaris and water are mixed to obtain bacterial liquid; and after composite raw materials and the bacterial liquid are mixed, composite probiotic powder fermentation, enzymolysis and filtration are conducted, and the fermented small molecule peptide mixed liquid is obtained. The small molecule peptide mixed liquid is obvious in uric acid reducing effect, small in side effect and capable of being applied to preparation of uric acid reducing drugs.

Description

technical field [0001] The invention relates to the field of extraction of small molecular peptide mixed liquid, in particular to a fermented small molecular peptide mixed liquid with the effect of reducing uric acid and its preparation method and application. Background technique [0002] With the rapid development of China's economy, people's living standards are constantly improving. Due to changes in people's diet structure such as high-calorie, high-fat, and high-sugar, more and more people are suffering from gout. [0003] Gout is a group of diseases caused by disorders of purine metabolism and decreased excretion of uric acid. The clinical features are hyperuricemia, recurrent acute monoarthritis, tophi deposits formed by sodium urate salt, tophi chronic arthritis, etc., and eventually it usually develops into gouty nephropathy. Therefore, it is very important to maintain a healthy level of uric acid. [0004] At present, gout is mainly treated by Western medicine,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61K36/8994A61P19/06C12P21/06C07K1/34
CPCA61K36/068A61K36/076A61K36/28A61K36/489A61K36/62A61K36/744A61K36/8994A61K38/011A61K2236/19A61P19/06C07K1/34C12P21/06A61K2300/00
Inventor 葛振龙高波阿斯姆古丽·阿布都热依木马圣明陈乃澎李秉玺费宇鹏康明赵海峰韩葳葳李婉南王浩韩璐常浩郭明昊赵国安周喜鹏
Owner JILIN PROVINCE TEYIFOOD BIOTECH CO LTD
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