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Uric-acid-lowering traditional Chinese medicine composition and application thereof

A technology of traditional Chinese medicine and uric acid, which is applied in the direction of drug combination, application, and medical preparations containing active ingredients, etc., can solve the problems of poor patient compliance, easy recurrence of pain, ascending paralysis, etc., and achieve the reduction of uric acid level and market promotion value High, the effect of promoting uric acid excretion

Inactive Publication Date: 2019-07-26
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs that reduce uric acid production include xanthine oxidase (XOD) inhibitors such as allopurinol and fexbuxostat, and uricosuric drugs include probenecid, sulfazone, benzbromarone, etc. The urate transporter of the convoluted tubules, thereby inhibiting the reabsorption of uric acid. In addition, colchicine, non-steroidal anti-inflammatory analgesics, adrenal glucocorticoids and probenecid are also used. Although such western medicines have quick effects, However, most of them treat the symptoms but not the root cause, and the pain is easy to recur after stopping the drug, and these drugs often have relatively large toxic and side effects. In addition to causing gastrointestinal reactions, long-term use may also lead to bone marrow suppression, liver cell damage, mental depression, and paralysis, respiratory depression and other side effects, so the currently marketed uric acid-lowering drugs are very limited, and due to obvious side effects, patients' compliance is poor

Method used

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  • Uric-acid-lowering traditional Chinese medicine composition and application thereof
  • Uric-acid-lowering traditional Chinese medicine composition and application thereof
  • Uric-acid-lowering traditional Chinese medicine composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The traditional Chinese medicine combination for lowering uric acid is prepared from the following components: 15-20 parts of Jiangxiangzi, 30-35 parts of ginger, 10-15 parts of lotus leaf, and 20-25 parts of poria cocos;

[0025] Each component is pulverized and mixed, and the powder is made into a powder after adding auxiliary materials according to a conventional preparation method;

[0026] In order to verify the uric acid-lowering effect of the traditional Chinese medicine combination of this embodiment, a comparative test study on the reduction of hyperuricemia by the composition was carried out: male Kunming mice were divided into four groups with equal numbers, which were control group, model group, allopurinol group, In the treatment group, the model group, the allopurinol group, and the treatment group were treated with high uric acid by intraperitoneal injection of oxonic acid potassium salt (300 mg / kg one-time intraperitoneal injection). The allopurinol grou...

Embodiment 2

[0031] The traditional Chinese medicine combination for lowering uric acid is prepared from the following components: 15-20 parts of Jiangxiangzi, 30-35 parts of ginger, 10-15 parts of lotus leaf, and 20-25 parts of poria cocos;

[0032] The preparation method of the Chinese medicine combination that the present embodiment reduces uric acid is as follows:

[0033] (1) 15-20 parts of Jiangxiangrui and 30-35 parts of ginger were extracted by traditional ethanol heat reflux extraction method, the mass volume ratio of the extraction material to liquid g:mL was 1:12, the ethanol concentration of the extract was 70%, and the single extraction time 1 hour, extraction 3 times, the extraction temperature is 55°C, after the extraction is completed, the supernatant is recovered with ethanol, concentrated, dried and dusted to obtain the corresponding extract;

[0034] (2) 10-15 parts of lotus leaf and 20-25 parts of Poria cocos were respectively extracted by traditional hot water reflux e...

Embodiment 3

[0041] The traditional Chinese medicine combination for lowering uric acid is prepared from the following components: 15-20 parts of Jiang Xiangru, 30-35 parts of ginger, 10-15 parts of lotus leaf, 20-25 parts of poria cocos, 15-20 parts of wolfberry, and 15-20 parts of red dates 15-20 parts of hawthorn;

[0042] The preparation method of the Chinese medicine combination that the present embodiment reduces uric acid is as follows:

[0043] (1) 15-20 parts of Jiangxiangrui and 30-35 parts of ginger were extracted by traditional ethanol heat reflux extraction method, the mass volume ratio of the extraction material to liquid g:mL was 1:12, the ethanol concentration of the extract was 70%, and the single extraction time 1 hour, extraction 3 times, the extraction temperature is 55°C, after the extraction is completed, the supernatant is recovered with ethanol, concentrated, dried and dusted to obtain the corresponding extract;

[0044] (2) 10-15 parts of lotus leaf, 20-25 parts o...

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Abstract

The invention discloses a uric-acid-lowering traditional Chinese medicine composition, comprising, by mass, 15-20 parts of Elsholtzia haichowensis herb, 30-35 parts of dried ginger, 10-15 parts of lotus leaf, and 20-25 parts of Indian bread. The medicinal and edible Chinese herbs having high safety are selected; comparative analysis is carried out through mass safety and pharmacodynamic tests; theproduct formulas and formula ratio are optimized and screened continuously; multiple detection and analysis items performed on the composition herein show that the composition has evident uric-acid-lowering effect, high safety, zero evident side effects and high marketing value.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy and food therapy products, in particular to a traditional Chinese medicine combination for reducing uric acid. Background technique [0002] Gout is a metabolic disease caused by excessive uric acid or reduced excretion of uric acid and accumulation of precipitates in the body, which leads to the disorder of purine metabolism in the body. [0003] With the improvement of people's living standards and changes in diet structure, the incidence of gout is increasing year by year. The growth rate of sales of anti-gout drugs has been maintained at more than 30% almost every year, which shows that there are many people with gout. Hyperlipidemia refers to excessive blood lipid levels, and hyperlipidemia and obesity also have abnormally high uric acid. Zhao Lanjiang et al studied the relationship between serum uric acid levels and triglycerides and concluded that serum uric ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P19/06A23L33/105A23L2/38A23C9/156
CPCA61K36/53A61K36/9068A61K36/62A61K36/076A61K36/815A61K36/725A61K36/734A61P19/06A23L33/105A23L2/38A23C9/156A61K2236/331A61K2236/333A23V2002/00A61K2300/00A23V2200/26A23V2250/21
Inventor 刘志勇罗小泉李守明洪滔雷丹李龙雪舒坤
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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