Method for extracting purified tracheloside from safflower seeds

A technology for purifying safflower glycosides and safflower seeds, which is applied in chemical instruments and methods, organic chemistry, preparation of sugar derivatives, etc., can solve problems that are unfavorable to human health and environmental protection, unfavorable to industrial production, and complex processes, etc., to achieve Easy to operate, strong pertinence, simple process effect

Active Publication Date: 2018-01-19
陕西嘉禾药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process is too complicated, and through silica gel column chromatography, the cost is too large, which is not conducive to industrial production
The use of chloroform, petroleum ether, ethyl acetate and other reagents is not conducive to human health and environmental protection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The raw material of safflower seeds is 50Kg, and the oil is pressed at low temperature to obtain 10Kg of clear and translucent safflower seed oil. The residue obtained after oil extraction was crushed to 100 mesh, added 235Kg 90% ethanol to extract twice at 40°C, combined the extracts, concentrated to a specific gravity of 1.03-1.05, added 2.5Kg of 320 activated carbon and 1.5Kg of activated clay, decolorized at 70°C for 1 hour, and filtered , the filtrate is purified with 16.7Kg LX-T5 anion resin, collects the adsorption effluent, adjusts the pH to 3-5 with hydrochloric acid, filters, and the filtrate adds the mixed solution of equal volume n-butanol and ethanol (the volume ratio of n-butanol and ethanol is 9:1) extracted twice, combined n-butanol extracts, concentrated to 1250ml, left to crystallize. Filtration and drying yielded crude crystals. Crush the crude crystals to 80 mesh, add 200ml of 80% ethanol, stir and dissolve at room temperature for 30 minutes, filter...

Embodiment 2

[0036] The raw material of safflower seeds is 50Kg, and the oil is pressed at low temperature to obtain 10Kg of clear and translucent safflower seed oil. The residue obtained after oil extraction was crushed to 100 mesh, added 235Kg 90% ethanol to extract twice at 40°C, combined the extracts, concentrated to a specific gravity of 1.03-1.05, added 4Kg of 767 activated carbon and 2.5Kg of activated clay to decolorize at 70°C for 1 hour, filtered, Purify the filtrate with 10Kg D958 anion resin, collect the adsorption effluent, adjust the pH to 3-5 with hydrochloric acid, filter, add an equal volume of mixed solution of n-butanol and ethanol to the filtrate (the volume ratio of n-butanol and ethanol is 7:1) Extracted twice, combined n-butanol extracts, concentrated to 750ml, left to crystallize. Filtration and drying yielded crude crystals. Crush the crude crystals to 80 mesh, add 100ml of 90% ethanol, stir and dissolve at room temperature for 30min, filter, precipitate and dry t...

Embodiment 3

[0038] The raw material of safflower seeds is 50Kg, and the oil is pressed at low temperature to obtain 10Kg of clear and translucent safflower seed oil. The residual meal obtained after oil extraction was crushed to 100 mesh, added 235Kg 90% ethanol to extract twice at 40°C, combined the extracts, concentrated to a specific gravity of 1.03-1.05, added 3Kg of HB-F activated carbon and 2Kg of activated clay for decolorization at 70°C for 1 hour, and filtered , the filtrate is purified with 12.5Kg WZ-D814 anion resin, collects the adsorption effluent, adjusts the pH to 3-5 with hydrochloric acid, filters, and the filtrate adds the mixed solution of equal volume n-butanol and ethanol (the volume ratio of n-butanol and ethanol is 8:1) extracted twice, combined n-butanol extracts, concentrated to 1000ml, left to crystallize. Filtration and drying yielded crude crystals. Crush the crude crystals to 80 mesh, add 160ml of 85% ethanol, stir and dissolve at room temperature for 30 minu...

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PUM

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Abstract

The invention provides a method for extracting purified tracheloside from safflower seeds, and mainly solves the problems of low yield, unsuitability for industrial production and complicated processin the prior art. The method mainly comprises the following steps that firstly, raw materials of safflower seeds are subjected to oil expression; then, obtained safflower seed meal is smashed; ethyl alcohol is used for extraction; next, extracting liquid is concentrated, decolored and filtered; filter liquid is purified by anion resin; effluent liquid is collected and adsorbed; then, the pH is regulated to be 3 to 5 by hydrochloric acid; filtering is performed; an organic solution is added into the filter liquid for extraction and concentration; placing crystallization, filtering and drying are performed to obtain macrocrystallines; finally, the macrocrystallines are smashed; the ethyl alcohol is used for stirring and dissolution; filtering is performed; precipitates are collected; dryingis performed to obtain the tracheloside. The method has the advantages that the residual meal obtained after the oil expression of the safflower seeds is effectively utilized; the tracheloside is obtained through separation and purification from the residual meal; the goal of changing waste into valuable is realized, so that the resources are comprehensively utilized; the raw material cost is reduced; the whole process is simple; the operation is easy; the yield is high; the quality is stable.

Description

technical field [0001] The invention belongs to the technical field of extraction and purification, and in particular relates to a method for extracting and purifying safflower seeds. Background technique [0002] Safflower, also known as grass safflower, chrysanthemum safflower, red orchid, Du safflower, etc., is an annual dicotyledonous Compositae herb. Safflower seeds are seeds derived from safflower, which are smaller than sunflower seeds. The traditional Chinese medicine name is "Baipingzi". Safflower seeds contain 25%-37% oil, 15%-19% crude protein, and more than 55% oil in the kernel. The content of essential fatty acids in safflower oil is more than 80%, especially linoleic acid is one of the two essential fatty acids, and its importance to improving human health has been more and more widely recognized in the medical field. It has the reputation of "vascular scavenger" and has the effect of preventing atherosclerosis, hypercholesterolemia and hyperlipidemia. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/26C07H1/08
Inventor 张瑜肖红王晓莹耿道元郭伟妮
Owner 陕西嘉禾药业有限公司
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