The invention relates to an
androstenedione purification method comprising the steps of
crystal washing and recrystallizaiton, wherein a composite
solvent composed of normal
hexane and
ethyl acetate in the proportion of 1:1 is adopted in the step of
crystal washing, and methyl
alcohol is used as a
solvent in the step of recrystallization. The
androstenedione purification method comprises the concrete steps of: (1) primary
crystal washing: adding a
macrocrystalline and a composite
solvent according to the proportion of 1:2.5, stirring the
macrocrystalline and the composite solvent for 2h, and then, carrying out
centrifugal separation to obtain crystal
powder A; (2) secondary crystal washing: adding the crystal
powder A and the composite solvent according to the proportion of 1:2, stirring the crystal
powder A and the composite solvent for 2h, and then, carrying out
centrifugal separation to obtain crystal powder B; (3) recrystallization:
drying the crystal powder B, and then recrystallizing by using the methyl
alcohol to obtain a finished product with the purity of over 99%, wherein the dosage ratio of the methyl
alcohol to the crystal powder B is 1:16; and (4) solvent
recovery: inspissating the washing solutions obtained in the primary and secondary crystal washing processes through a membrane lifting
concentrator to recover the composite solvent. By using the
androstenedione purification method, impurities can be effectively removed, the operation can be simplified, a great number of solvents can be saved, the
energy consumption during solvent
recovery is also reduced, and finally, the finished product with the purity of over 99% is obtained.