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Chinese and western combined anti-thrombotic medicine composition and preparation method thereof

A technology of antithrombotic drugs and compositions, applied in the field of medicine, can solve the problems of long antithrombotic time and patients giving up treatment, and achieve the effect of reducing toxic side effects and enhancing antithrombotic effect

Inactive Publication Date: 2018-02-02
余必亚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antithrombotic time is long, and it is easy for patients to give up treatment, so it is necessary to continue to explore and develop new thrombolytic drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of a combination of Chinese and Western antithrombotic pharmaceutical composition, comprising the steps of:

[0025] S1: Weigh 22 parts of Dannanxing, 22 parts of Coptis chinensis, 22 parts of Wang Buliuxing, 15 parts of Chuanniu lacquer, 15 parts of dandelion, 15 parts of golden worm, and 12 parts of Scrophulariaceae, make them into pieces, add water and decoct 3 times , add 8 times the amount of water for the first time, decoct for 2 hours; add 6 times the amount of water for the second time, decoct for 1.5 hours; add 4 times the amount of water for the third time, decoct for 1 hour; filter, combine the filtrate, and decompress the filtrate Concentrate to 3 times the amount of the raw material, add ethanol with a mass concentration of 75%, stand still for 48 hours, remove the supernatant, concentrate and dry the precipitate under reduced pressure, and crush it into a fine powder for later use;

[0026] S2: Weigh 2.5 parts of beraprost and 2.5 part...

Embodiment 2

[0029] A preparation method of a combination of Chinese and Western antithrombotic pharmaceutical composition, comprising the steps of:

[0030] S1: Weigh 24 parts of Dannanxing, 24 parts of Coptis chinensis, 23 parts of Wang Buliuxing, 18 parts of Chuanniu lacquer, 18 parts of dandelion, 18 parts of golden worm, and 14 parts of Scrophulariaceae, make into pieces, add water and decoct 3 times , add 8 times the amount of water for the first time, decoct for 2 hours; add 6 times the amount of water for the second time, decoct for 1.5 hours; add 4 times the amount of water for the third time, decoct for 1 hour; filter, combine the filtrate, and decompress the filtrate Concentrate to 3 times the amount of the raw material, add ethanol with a mass concentration of 75%, stand still for 48 hours, remove the supernatant, concentrate and dry the precipitate under reduced pressure, and crush it into a fine powder for later use;

[0031] S2: Weigh 3 parts of beraprost and 3 parts of dipy...

Embodiment 3

[0034] A preparation method of a combination of Chinese and Western antithrombotic pharmaceutical composition, comprising the steps of:

[0035] S1: Weigh 25 parts of Dannanxing, 25 parts of Coptis chinensis, 25 parts of Wangbuliuxing, 21 parts of Chuanniu lacquer, 21 parts of dandelion, 21 parts of golden worm, and 15 parts of Scrophulariaceae, make them into pieces, add water and decoct 3 times , add 8 times the amount of water for the first time, decoct for 2 hours; add 6 times the amount of water for the second time, decoct for 1.5 hours; add 4 times the amount of water for the third time, decoct for 1 hour; filter, combine the filtrate, and decompress the filtrate Concentrate to 3 times the amount of the raw material, add ethanol with a mass concentration of 75%, stand still for 48 hours, remove the supernatant, concentrate and dry the precipitate under reduced pressure, and crush it into a fine powder for later use;

[0036] S2: Weigh 4.5 parts of beraprost and 4.5 parts...

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PUM

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Abstract

A combination of Chinese and Western antithrombotic pharmaceutical composition and its preparation method. The pharmaceutical composition is compounded by Chinese medicine ingredients and Western medicine ingredients. In parts by weight, the Chinese medicine ingredients include the following raw materials: Dannanxing 22‑25 parts , 22-25 parts of Coptis chinensis, 22-25 parts of Wang Buliuxing, 15-21 parts of Chuanniu lacquer, 15-21 parts of Dandelion, 15-21 parts of golden worm, 12-15 parts of Scrophulariaceae; the western medicine ingredients include the following Raw materials: 2.5-4.5 parts of beraprost, 2.5-4.5 parts of dipyridamole. The anti-cerebral thrombosis combined Chinese and Western medicine composition of the present invention adopts the method of combining Chinese and Western medicines, selects a variety of Chinese herbal medicines and Western medicines, and cooperates with each other to enhance the antithrombotic effect, reduce the toxic and side effects of pure Western medicines, promote blood circulation, remove blood stasis, warm meridian and dredge collaterals, Playing together to invigorate qi and activate blood, resuscitate and relieve pain, it has very significant effects on the prevention or treatment of cerebral thrombosis, myocardial infarction and other diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a combination of Chinese and western antithrombotic medicine composition and a preparation method thereof. Background technique [0002] Acute attack of cerebral thrombosis is a very dangerous disease. Because ischemia causes many pathological changes such as nerve necrosis and brain tissue inflammation in the brain. The target of western medicine is single, and western medicine needs to use multiple drugs such as thrombolysis, neuroprotection, anti-inflammation, and nutrition in combination for each lesion, and the cost is high. Moreover, most western medicines have drug resistance to varying degrees, and most western medicines have obvious side effects, causing varying degrees of damage to the gastrointestinal tract, liver and kidneys. [0003] In the treatment of cerebral thrombosis, traditional Chinese medicine has the advantages of strong long-term effect, str...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8884A61P7/02A61P9/10A61K31/519A61K31/5585A61K35/646
CPCA61K36/8884A61K31/519A61K31/5585A61K35/646A61K36/21A61K36/288A61K36/36A61K36/718A61K36/808A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 余必亚
Owner 余必亚
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