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A kind of preparation method of macroporous adsorption resin for polyphenol purification

A pore adsorption and resin technology, which is applied in the field of preparation of macroporous adsorption resins for polyphenol purification, can solve the problems of high separation cost, low adsorption efficiency, and low purity of flavonoids by liquid chromatography, and achieve high adsorption efficiency and large adsorption capacity , Improve the effect of adsorption performance

Active Publication Date: 2020-04-17
GUANGXI NORMAL UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] After polyphenols are extracted from plants, they need to be purified. The commonly used methods are extraction, resin adsorption and liquid chromatography separation. The extraction agent used in the extraction is usually an organic solvent, which is toxic, and the extracted flavonoids have a low purity. The cost of liquid chromatography separation is high and the efficiency is relatively low
Resin adsorption has the advantages of high efficiency and good polyphenol purification effect. The adsorption resin used in the existing polyphenol resin adsorption is a general-purpose adsorption resin, which generally has the disadvantages of small adsorption capacity and low adsorption efficiency.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preparation method of macroporous adsorption resin for polyphenol purification, comprising the following steps:

[0019] S1. In parts by weight, 5 parts of sodium chloride, 4 parts of gelatin and 3.3 parts of Tween60 are dissolved in 40 parts of water, and stirred evenly to obtain an aqueous phase;

[0020] S2. In parts by weight, take 2 parts of phenylacrylamide, 12 parts of styrene and ~1 part of 2,6-dichlorostyrene as a monomer, add 4.62 parts of ether and 7.38 parts of n-heptane to the monomer , 0.165 parts of dibenzoyl peroxide, 0.33 parts of Span80 and 0.8 parts of divinylbenzene are mixed to obtain an oil phase;

[0021] S3. In terms of parts by weight, add 40 parts of the water phase to the container, bathe in water at 25°C, then slowly add 15 parts of the oil phase to the water phase, stir at a speed of 1200r / min for 15min, and then adjust the speed to Stir continuously at 200r / min, raise the temperature of the water bath to 70°C for 4 hours, then raise the ...

Embodiment 2

[0024] A preparation method of macroporous adsorption resin for polyphenol purification, comprising the following steps:

[0025] S1. In parts by weight, 6 parts of sodium chloride, 2 parts of gelatin and 3.3 parts of Tween60 are dissolved in 40 parts of water, and stirred evenly to obtain an aqueous phase;

[0026] S2. In parts by weight, take 3 parts of phenylacrylamide, 11 parts of styrene and 0.5 parts of 2,6-dichlorostyrene as monomers, add 4.4 parts of ether, 10.1 parts of n-heptane, 0.16 parts of dibenzoyl peroxide, 0.275 parts of Span80 and 0.5 parts of divinylbenzene are mixed to obtain an oil phase;

[0027] S3. In terms of parts by weight, add 40 parts of the water phase to the container, bathe in water at 10°C, then slowly add 12 parts of the oil phase to the water phase, stir at a speed of 1500r / min for 20min, and then adjust the speed to Stir continuously at 300r / min, raise the temperature of the water bath to 68°C for 4 hours, then raise the temperature to 92°C...

Embodiment 3

[0030] A preparation method of macroporous adsorption resin for polyphenol purification, comprising the following steps:

[0031] S1. In parts by weight, 5 parts of sodium chloride, 3 parts of gelatin and 3.3 parts of Tween60 are dissolved in 40 parts of water, and stirred evenly to obtain an aqueous phase;

[0032] S2. In parts by weight, 2.5 parts of phenylacrylamide, 10 parts of styrene and 0.5 parts of 2,6-dichlorostyrene are mixed as monomers, and 3.9 parts of ether, 7.8 parts of n-heptane, 0.129 parts of dibenzoyl peroxide, 0.3 parts of Span80 and 0.6 parts of divinylbenzene are mixed to obtain an oil phase;

[0033] S3. In terms of parts by weight, add 40 parts of the water phase to the container, bathe in water at 20°C, then slowly add 14 parts of the oil phase to the water phase, stir at a speed of 1000r / min for 18min, and then adjust the speed to Stir continuously at 250r / min, raise the temperature of the water bath to 68°C and keep it for 4 hours, then raise the te...

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Abstract

The invention discloses a preparation method of macro-porous adsorption resin for polyphenol purification. The preparation method includes the steps: dissolving 5-6 parts of sodium chloride, 2-4 partsof gelatin and 3.3 parts of Tween 60 in 40 parts of water, and uniformly stirring mixture to obtain a water phase; taking benzyl acrylamide, phenylethylene and 2, 6-dichlorostyrene as monomers, taking mixture of diethyl ether and normal heptane as pore-foaming agents, taking divinyl benzene as cross-linking agents, mixing raw materials to prepare an oil phase, and adding the oil phase into the water phase to prepare the macro-porous adsorption resin by an inverse emulsion method. The macro-porous adsorption resin prepared by the preparation method has the advantages of high polyphenol adsorption quantity and high polyphenol adsorption efficiency.

Description

technical field [0001] The invention relates to a preparation method of a macroporous adsorption resin for polyphenol purification. Background technique [0002] Plant polyphenols, also known as plant tannins, are a secondary metabolite in plants with a polyphenol structure, and are the general term for polyhydric phenolic compounds. Plant polyphenols are very abundant in nature. There are more than 600 common plants containing polyphenols. The content in plants is second only to cellulose, hemicellulose and lignin. It mainly exists in the bark, roots and leaves of plants. And fruit. Polyphenols have a strong antioxidant effect, as well as obvious antibacterial, anti-cancer, anti-aging and inhibiting cholesterol rise effects. Taking a certain amount of polyphenols can effectively prevent and inhibit the occurrence of diseases. [0003] After polyphenols are extracted from plants, they need to be purified. The commonly used methods are extraction, resin adsorption and liqui...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F212/08C08F212/14C08F220/54C08F212/36C08F2/32C08J9/28B01J20/26
CPCB01J20/264C08F212/08C08J9/28C08J2325/08C08F220/54C08F212/14C08F212/36C08F2/32
Inventor 蓝峻峰覃逸明方毅林
Owner GUANGXI NORMAL UNIV OF SCI & TECH