Ion exchange resin purification method of alkaloid

The technology of an ion exchange resin and a purification method is applied in the field of ion exchange resin and achieves the effects of a friendly process environment, low production cost and simple and easy purification process.

Inactive Publication Date: 2018-02-23
王鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problem of alkaloid purification in the prior art, and provides an ion exchange resin purification method for alkaloids. The method adopts macroporous cation exchange resins for ion exchange purification of alkaloids, and has the advantages of simple process operation and high product purity. high advantage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A kind of ion exchange resin purification method of alkaloid, comprises the following processing steps:

[0017] A. Transfer the macroporous cation exchange resin to the exchange column; wash the resin with 95% alcohol until the effluent does not produce white turbidity in water; wash the alcohol in the macroporous resin in the exchange column with deionized water; use 1NNaOH and 1N HCl is alternately passed through the exchange column to perform ion exchange treatment on the resin, and finally treated with 1NNaOH; wash the residual NaOH in the exchange column with deionized water, and set it aside;

[0018] B. Make the alkaloid extract pass through the exchange column from top to bottom at a flow rate of 100ml / h; wash the alkaloid extract remaining in the chromatography column with deionized water after the extract is passed through; use 1NNaOH to elute the alkaloid adsorbed by the resin ; Collect the effluent;

[0019] C. Neutralize with 1N HCl; further concentrate t...

Embodiment 2

[0021] A kind of ion exchange resin purification method of alkaloid, comprises the following processing steps:

[0022] A. Transfer the macroporous cation exchange resin to the exchange column; wash the resin with 95% alcohol until the effluent does not produce white turbidity in water; wash the alcohol in the macroporous resin in the exchange column with deionized water; use 1NNaOH and 1N HCl is alternately passed through the exchange column to perform ion exchange treatment on the resin, and finally treated with 1NNaOH; wash the residual NaOH in the exchange column with deionized water, and set it aside;

[0023] B. Make the alkaloid extract pass through the exchange column from top to bottom at a flow rate of 150ml / h; wash the alkaloid extract remaining in the chromatography column with deionized water after the extract is passed through; use 1NNaOH to elute the alkaloid adsorbed by the resin ; Collect the effluent;

[0024] C. Neutralize with 1N HCl; further concentrate t...

Embodiment 3

[0026] A kind of ion exchange resin purification method of alkaloid, comprises following process step:

[0027] A. Transfer the macroporous cation exchange resin to the exchange column; wash the resin with 95% alcohol until the effluent does not produce white turbidity in water; wash the alcohol in the macroporous resin in the exchange column with deionized water; use 1NNaOH and 1N HCl is alternately passed through the exchange column to perform ion exchange treatment on the resin, and finally treated with 1NNaOH; wash the residual NaOH in the exchange column with deionized water, and set it aside;

[0028] B. Make the alkaloid extract pass through the exchange column from top to bottom at a flow rate of 125ml / h; wash the alkaloid extract remaining in the chromatography column with deionized water after the extract is passed; use 1N NaOH to elute the alkaloid adsorbed by the resin ; Collect the effluent;

[0029] C. Neutralize with 1N HCl; further concentrate the extract to o...

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Abstract

The invention relates to an ion exchange resin purification method for alkaloids, belonging to the technical field of ion exchange resins. The present invention adopts macroporous cation exchange resin resin method to separate and purify the alkaloid effective components in Chinese herbal medicine, so that the alkaloid can be purified. Compared with the traditional process, the purification process is simple and feasible, the production efficiency is high, the product yield is high, and the process environment is friendly. , low production cost and other advantages.

Description

technical field [0001] The invention relates to an ion exchange resin purification method, more specifically, the invention relates to an alkaloid ion exchange resin purification method, which belongs to the technical field of ion exchange resins. Background technique [0002] Alkaloids are organic bases with physiological activity and are a large class of basic organic compounds. Most of them are distributed in various Chinese herbal medicines and are one of the main active ingredients of Chinese herbal medicines. The traditional preparation method is to extract alkaloids from Chinese medicinal materials by water extraction first, then use alcohol precipitation to remove a large amount of impurities such as polysaccharides, and finally concentrate to obtain the product. [0003] The purity of the alkaloid prepared by this process is not high, and the curative effect of the alkaloid medicine prepared by using this as raw material is not obvious. Simultaneously, the prepare...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J47/02B01J49/53B01J39/00A61K36/00
CPCB01J47/02A61K36/00B01J39/00B01J49/53
Inventor 王鹏
Owner 王鹏
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