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Preparation method of water-based strontium substituted hydroxyapatite colloidal liquid crystal

A strontium hydroxyapatite, liquid crystal technology, applied in chemical instruments and methods, phosphorus compounds, nanotechnology for materials and surface science, etc., to achieve the effects of low cost, abundant sources and easy availability, and simple synthesis process

Active Publication Date: 2018-03-02
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the research on strontium hydroxyapatite inorganic colloidal liquid crystals. It is assumed that an anisotropic strontium hydroxyapatite nanoparticle liquid crystal state (closest to the bone microstructure) dispersion system can be successfully prepared and successfully applied in nanocomposites. , it is bound to be able to realize the structural bionics of artificial bone in the true sense, comprehensively improve the mechanical properties of bone repair substitute materials, and benefit patients with bone defects

Method used

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  • Preparation method of water-based strontium substituted hydroxyapatite colloidal liquid crystal
  • Preparation method of water-based strontium substituted hydroxyapatite colloidal liquid crystal
  • Preparation method of water-based strontium substituted hydroxyapatite colloidal liquid crystal

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Experimental program
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Effect test

Embodiment 1

[0028] 1) 0.01mol of strontium nitrate was dissolved in 10 grams of deionized water to form solution A;

[0029] 2) 0.005mol potassium citrate was dissolved in 10 grams of deionized water to form solution B;

[0030] 3) Dissolving 0.006mol of sodium phosphate in 10 grams of deionized water to form solution C;

[0031] 4) Add the solution B obtained in step 2) to the solution A obtained in step 1) dropwise at room temperature, and fully stir for 15 minutes to form a mixed solution D;

[0032] 5) Add the solution C obtained in step 3) to the mixed solution D obtained in step 4) dropwise at room temperature, and fully stir for 15 minutes to form the mixed solution E;

[0033] 6) Transfer the mixed solution E obtained in step 5) to a closed hydrothermal reactor, react at 90° C. for 24 hours, and then naturally cool to room temperature to obtain a reaction solution;

[0034] 7) Use a high-speed centrifuge to centrifuge the reaction solution in step 6) to obtain a precipitate, and...

Embodiment 2

[0036] Embodiment 2, with embodiment 1, the difference is,

[0037] 1) 0.01mol of strontium nitrate was dissolved in 10 grams of deionized water to form solution A;

[0038] 2) 0.005mol potassium citrate was dissolved in 10 grams of deionized water to form solution B;

[0039] 3) Dissolving 0.006moll of ammonium phosphate in 10 grams of deionized water to form solution C;

[0040] 6) Transfer the mixed solution E obtained in step 5) to a closed hydrothermal reactor, react at 120° C. for 18 hours, and then naturally cool to room temperature to obtain a reaction solution;

[0041] 7) Use a high-speed centrifuge to centrifuge the reaction solution in step 6) to obtain a precipitate, and use deionized water and absolute ethanol to alternately centrifuge and wash three times to remove excess electrolyte in the system, then redisperse in deionized water, and adjust the pH to 8.5 , to obtain a stable strontium hydroxyapatite colloidal dispersion;

[0042] The concentration of the ...

Embodiment 3

[0043] Embodiment 3, with embodiment 1, the difference is,

[0044] 1) 0.01mol of strontium nitrate was dissolved in 10 grams of deionized water to form solution A;

[0045] 2) 0.005mol ammonium citrate was dissolved in 10 grams of deionized water to form solution B;

[0046] 3) Dissolving 0.006moll potassium phosphate in 10 grams of deionized water to form solution C;

[0047] 6) Transfer the mixed solution E obtained in step 5) to a closed hydrothermal reactor, react at 150° C. for 12 hours, and then naturally cool to room temperature to obtain a reaction solution;

[0048] 7) Use a high-speed centrifuge to centrifuge the reaction solution in step 6) to obtain a precipitate, then use deionized water and absolute ethanol to alternately centrifuge and wash three times to remove excess electrolyte in the system, then redisperse in deionized water, and adjust the pH to 9.0 , to obtain a stable strontium hydroxyapatite colloidal dispersion;

[0049] The concentration of the st...

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Abstract

The invention relates to a preparation method of water-based strontium substituted hydroxyapatite colloidal liquid crystal. The method comprises the following steps that soluble strontium salt is dissolved in deionized water to form a solution A; soluble citrate is dissolved in deionized water to form a solution B; soluble phosphate is dissolved in deionized water to form a solution C; the solution B is dropwise added into the solution A; the mixed solution is stirred to form mixed liquid D; the solution C is dropwise added into the mixed liquid D; stirring is performed to form mixed liquid E;the mixed liquid E is poured into a sealed hydrothermal reactor; reaction is performed for 3 to 24h at 90 to 200 DEG C; then, natural cooling is performed to room temperature; centrifugation is performed by a high-speed centrifuge; obtained precipitates are alternately and centrifugally washed by deionized water and absolute ethyl alcohol; the washed precipitates are dispersed into the deionizedwater again; the pH is regulated; stable colloidal dispersion liquid is obtained; concentration is performed to the critical transition concentration or higher; the colloidal liquid crystal is obtained through preparation. The preparation method has the advantages that the raw materials are nontoxic and green; the resources are rich and can be easily obtained; the cost is low; the synthetic process is simple; the implementation is easy; the repeatability is good; the preparation method can be used in the fields of biomedical materials and the like.

Description

technical field [0001] The invention belongs to the preparation technology of inorganic lyotropic liquid crystals, in particular to a preparation method of water-based strontium hydroxyapatite colloidal liquid crystals. Background technique [0002] The hard tissues of many organisms in nature are not only light but also have excellent mechanical properties, such as shells, animal bones and teeth. Studies have shown that these excellent properties originate from the highly ordered distribution of anisotropic inorganic nanoparticles in the polymer matrix in hard tissues. The bones and teeth of mammals in nature are the result of highly ordered composites of rod-shaped hydroxyapatite nanoparticles and collagen. [0003] Originating from the biomimicry of natural hard tissue and meeting the society's increasing urgent demand for replacement materials for human hard tissue, people have carried out in-depth research on strontium hydroxyapatite / polymer nanocomposites. For most a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00C01B25/325C01P2002/72C01P2004/03C01P2004/16
Inventor 谭军军程诚刘伟熊焰刘洋
Owner HUBEI UNIV OF TECH
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