Sodium potassium hydrogen citrate solution for aerosol inhalation

A technology of potassium hydrogen citrate and sodium aerosol inhalation, which is applied in the field of pharmacy and can solve the problems of large clinical adverse reactions and poor compliance of children

Inactive Publication Date: 2018-03-06
BEIJING BEIPENG SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are few western medicine expectorant drugs on the market, and there are very few expectorant drugs for nebulization inhalation. Only acetylcysteine ​​inhalation solution and ambroxol hydrochloride inhalation solution are used for nebulization inhalation, and these two drugs There are also reports in the literature that there are large clinical adverse reactions and poor compliance in children

Method used

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  • Sodium potassium hydrogen citrate solution for aerosol inhalation
  • Sodium potassium hydrogen citrate solution for aerosol inhalation
  • Sodium potassium hydrogen citrate solution for aerosol inhalation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-9

[0005] According to the ingredient ratio shown in Table 1, each material is mixed according to the corresponding ingredient ratio and mixed with water to the corresponding volume. During the preparation process, the acid is first and the alkali is added. The solid material is slowly added to the water and stirred while adding to prevent the temperature from rising. High, then, respectively sub-package into each preparation unit is 2ml solution preparation for nebulization inhalation, filled with nitrogen, sealed, closed light preservation.

[0006]

Embodiment 10

[0007] Embodiment 10 pharmacodynamic test

[0008] According to the ingredient ratio shown in Table 2, the pharmacodynamics experimental samples and control samples were prepared.

[0009]

[0010] According to the ingredient ratio shown in Table 2, add each material according to the corresponding ingredient ratio and mix with water for injection to a corresponding volume of 1000 ml. During the preparation process, first acid and then alkali, slowly add the solid material into the water, and stir while adding , to prevent the temperature from rising, and then, respectively aliquoted, nitrogen, sealed, and stored in a closed light, and the positive control sample was selected to have a concentration of 1.0% ambroxol solution. Take the weight at 20 + 1g of Kunming mice were starved overnight the day before the experiment and only provided drinking water. They were randomly divided into four groups, with 10 mice in each group. , inject 30 microliters of liquid medicine in ad...

Embodiment 11-17

[0013] The influence of embodiment 11-17 potassium hydrogen citrate sodium hydrogen citrate on cilia movement

[0014] According to the ingredient ratio shown in Table 4, each material is mixed according to the corresponding ingredient ratio. The preparation process is first acid and then alkali. Slowly add the solid material into the water and stir while adding to prevent the temperature from rising. Pack each preparation unit into a solution preparation for atomization and inhalation of 2ml, fill with nitrogen, seal, and store in darkened light, and prepare a solution with the same citrate concentration of 7% and different potassium and sodium:citrate ratios.

[0015]

[0016] 24 domestic pigeons weighing 300±20 g were selected and randomly divided into 4 groups. Each group is followed by normal saline control group, 2.5 ratio of potassium sodium hydrogen citrate (embodiment 12) group, 2.7 ratio of potassium hydrogen citrate (embodiment 14) group, 2.95 ratio of potassium ...

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Abstract

The invention provides an aqueous solution preparation of sodium potassium hydrogen citrate for aerosol inhalation, wherein the aqueous solution preparation is used for reducing phlegm. In the aqueoussolution preparation of sodium potassium hydrogen citrate, the concentration of citrate is 10 to 110 mg / ml; a mol ratio of sodium ions to potassium ions is 1: 1; and the total mole number of sodium ions and potassium ions is 2.35 to 2.95 times the mole number of citrate ions.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular, the invention relates to an atomized inhalation solution containing potassium hydrogen citrate sodium. Background technique [0002] Drug nebulization inhalation therapy, as a new treatment method, uses high-speed airflow or ultrasound to atomize drug solution into particles with a diameter of less than 5 microns, which are inhaled and deposited in the respiratory tract and alveoli to achieve the purpose of treating diseases and improving symptoms. Compared with systemic administration, atomized inhalation therapy has the effects of small drug dosage, quick onset, and increased local drug concentration, and is very suitable for the application of expectorant drugs. There are few western medicine expectorant drugs on the market, and there are very few expectorant drugs for nebulization inhalation. Only acetylcysteine ​​inhalation solution and ambroxol hydrochloride inhalation solution are us...

Claims

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Application Information

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IPC IPC(8): A61K31/194A61K33/00A61K9/08A61K9/12A61K9/72A61P11/10
CPCA61K31/194A61K9/0073A61K9/08A61K33/00A61K2300/00
Inventor 杨春红郜梓健
Owner BEIJING BEIPENG SCI & TECH
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