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Yanlixiao capsule and preparation method thereof

A technology of capsules and cloves, which is applied in the fields of capsule transportation, digestive system, and pharmaceutical formulations, can solve the problems of poor capsule stability, unsatisfactory curative effect, and poor process repeatability, so as to reduce the dosage of drugs, reduce pharmaceutical costs, The effect of process stability

Inactive Publication Date: 2018-03-06
黑龙江迪龙制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the composition and process of commercially available Yanlixiao Capsules, most of them have added functional excipients, resulting in unsatisfactory curative effect. The preparation is prepared by traditional technology, which has the disadvantages of slow dissolution and low curative effect.
The Yanlixiao capsule disclosed by CN1030184A has poor process repeatability and poor stability of the prepared capsule

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1) Preparation of clove leaf fine powder: take clean clove leaves, put them in a pulverizer, pulverize them into fine powder, and pass through a No. 5 sieve for later use.

[0029] 2) Preparation of clove leaf clear paste: take 100 kg of clean clove leaves, put them in an extraction tank, add 800 kg of purified water, and decoct (slightly boil after boiling) for 2 hours. Filter and use the filtrate for later use. Add 800kg of purified water to the extraction tank, and decoct (slightly boil after boiling) for 1 hour. Filter and combine the primary and secondary filtrates. Concentrate and combine the filtrates under reduced pressure to a clear paste with a relative density of the concentrated solution of 1.23-1.27 (80°C).

[0030] 3) Mixing: Weigh 11.68 kg of clove leaf fine powder, add it to the clear ointment, and mix evenly.

[0031] 4) Drying: Send the clove leaf fine powder and clear paste mixture into a vacuum dryer until the water content is less than 3%.

[00...

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PUM

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Abstract

The invention discloses a Yanlixiao capsule and a preparation method thereof. The Yanlixiao capsule is prepared from clove leaves through processing and is a pharmaceutical composition. The pharmaceutical composition does not contain any other raw and accessory materials except for components from the clove leaves. The preparation method for the pharmaceutical composition is characterized by comprising the following steps: (1) extracting clove leaves with water and concentrating the obtained water extract into clear paste with relative density of 1.23 to 1.27 (80 DEG C); (2) crushing clove leaves and then carrying out screening with a sieve No. 5 so as to obtain fine powder; and (3) uniformly mixing the fine powder prepared in the step (2) with the clear paste prepared in the step (1) anddrying the mixture so as to obtain the pharmaceutical composition. The Yanlixiao capsule provided by the invention is a purely traditional Chinese medicine, has substantial curative effect and small side-effect, and can overcome the problem of abuse of antibiotics; and the Yanlixiao capsule is free of any accessory material and has substantial better dissolution and stability than commercially available Yanlixiao capsules.

Description

technical field [0001] The invention provides a Yanlixiao capsule and a preparation method thereof. belongs to the field of pharmaceuticals. Background technique [0002] Yanlixiao Capsule has heat-clearing, detoxifying and anti-inflammatory effects, and is used for bacillary dysentery, acute tonsillitis, acute and chronic bronchitis, acute gastroenteritis, acute mastitis and other infectious diseases that belong to heat syndrome. Due to the composition and process of Yanlixiao Capsules on the market, most of them are added with functional excipients, resulting in unsatisfactory curative effect. The preparation is prepared by traditional technology, which has the disadvantages of slow dissolution and low curative effect. The Yanlixiao capsule disclosed in CN1030184A has poor process repeatability and poor stability of the prepared capsule. Contents of the invention [0003] In order to overcome the shortcomings of the existing Yanlixiao preparations in the prior art, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61K9/48A61P31/04A61P1/12A61P11/04A61P1/00A61P15/14A61P11/00
CPCA61K9/48A61K36/61A61K2236/331A61K2236/39A61K2236/51Y02A50/30
Inventor 董继胜于芳刘小丹
Owner 黑龙江迪龙制药有限公司
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