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Hollow open lignin nano-sphere and preparation method thereof

A technology of lignin and nanospheres, applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problems of lack of hollow structure and random morphology of nano-lignin

Pending Publication Date: 2018-03-09
INST OF WOOD INDUDTRY CHINESE ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patents CN102002165A, CN 103145999A, CN 103254452A and CN 104497322A respectively propose to prepare nano-lignin by supercritical anti-solvent method, high-pressure homogenization method, inorganic acid and cross-linking agent method and liquid phase deposition method, but the obtained nano-lignin They are all random in shape and do not have a hollow structure

Method used

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  • Hollow open lignin nano-sphere and preparation method thereof
  • Hollow open lignin nano-sphere and preparation method thereof
  • Hollow open lignin nano-sphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 5 mg of enzymatic lignin in a 250 mL beaker, add 10 mL of tetrahydrofuran, stir at 600 rpm, then titrate with 40 mL of deionized water at a speed of 2 mL / min, and finally transfer the suspension into a dialysis bag for dialysis for 24 h.

[0022] figure 2 It is the particle size distribution diagram of the hollow open lignin nanospheres measured by the laser particle size analyzer, and the average particle size is 419.2nm.

[0023] image 3 is a scanning electron micrograph of hollow open lignin nanospheres.

[0024] Figure 4 is a transmission electron micrograph of hollow open lignin nanospheres.

[0025] Figure 5 It is the infrared spectrogram of hollow open lignin nanospheres and lignin raw materials. It can be seen that the characteristic peaks have not changed before and after preparation, indicating that no chemical reaction has occurred before and after preparation.

Embodiment 2

[0027] Take 10 mg of enzymatic lignin in a 250 mL beaker, add 10 mL of tetrahydrofuran, stir at 600 rpm, then titrate 40 mL of deionized water at a speed of 2 mL / min, and finally transfer the suspension into a dialysis bag for dialysis for 24 h.

[0028] The average particle size measured by the laser optical particle size analyzer is 502.4 nm, which is larger than that in Example 1. In addition, the opening and hollow diameters are reduced compared to Example 1.

Embodiment 3

[0030] Put 15 mg of enzymatic lignin into a 250 mL beaker, add 10 mL of tetrahydrofuran, stir at 600 rpm, then titrate 40 mL of deionized water at a speed of 2 mL / min, and finally transfer the suspension into a dialysis bag for dialysis for 24 h.

[0031] The average particle size measured by the laser optical particle size analyzer is 515 nm, which is larger than that of Example 1. In addition, the opening and hollow diameters are reduced compared to Example 1.

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Abstract

The invention discloses a preparation method of a hollow open lignin nano-sphere. The preparation method comprises the following steps: 1, adding a proper amount of lignin raw materials into an organic solvent to dissolve; 2, under proper stirring speed, adding deionized water into an organic solution dropwise at proper speed, or adding an organic solution, in which lignin is dissolved, into deionized water at proper speed, and slowly forming a hollow open nano-sphere; 3, transferring suspension liquid into a dialysis bag to perform dialysis and removing the residual organic solvent; and 4, freeze-drying the suspension liquid after dialysis to finally obtain the hollow open lignin nano-sphere with the grain size of 50 to 600 nm. The prepared hollow open lignin nano-sphere can serve as a medicine carrier.

Description

technical field [0001] The invention relates to a method for preparing hollow open lignin nanospheres and the hollow open lignin nanospheres prepared by the method. Background technique [0002] Hollow nano- or microspheres exhibit lower density, higher specific surface area, and better surface permeability. They have potential applications in transport carriers, catalysts, coatings, and composite materials. When used for drug delivery, hollow spheres have a higher drug loading rate than solid spheres with a dense structure. Much research has been devoted to the preparation of hollow spheres with controllable composition, structure, and properties. Hollow open spheres have attracted extensive attention as a new hollow structure. In the current reports on the preparation of open hollow spheres, organic polymers and inorganic oxides are mainly used, such as polystyrene, polyacrylamide-ethylene glycol dimethacrylate, polystyrene / polydivinylbenzene , polystyrene / poly-3,4-eth...

Claims

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Application Information

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IPC IPC(8): B01J13/02
CPCB01J13/02
Inventor 韩雁明储富祥熊福全李改云秦特夫
Owner INST OF WOOD INDUDTRY CHINESE ACAD OF FORESTRY
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