A kind of medical tablet coating process

A coating and tablet technology, which is applied in the direction of pharmaceutical formula, drug delivery, medical preparations of non-active ingredients, etc., can solve the problems of poor moisture-proof and anti-oxidation effects, difficult to achieve moisture-proof and deterioration, and long drying time, etc., to achieve Good gloss, enhanced gloss, fast drying effect

Active Publication Date: 2020-12-22
上海国创医药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the existing coating is usually made of talcum powder, which has poor moisture-proof and anti-oxidation effects, and it is difficult to achieve a good moisture-proof and anti-deterioration effect after the tablet is coated.
Moreover, the existing coating process is usually to dry the tablet after all the coating is complete, which takes a long time and consumes a lot of energy.

Method used

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  • A kind of medical tablet coating process
  • A kind of medical tablet coating process
  • A kind of medical tablet coating process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A medical tablet coating process, comprising the following steps: (1) manufacturing paddle: mixing talcum powder, hydroxypropyl methylcellulose, and nano-scale silicon dioxide in a mixer to prepare paddle, wherein the talc Powder, hydroxypropyl methylcellulose, and nano-scale silicon dioxide are in parts by weight ratio of 2: 1.5: 1.3; specifically, 20kg of talcum powder, 15kg of hydroxypropyl methylcellulose, and 1.3kg of nano-scale (2) preheating tablet: place the tablet to be coated in the coating equipment, such as Figure 1-7 As shown, the coating equipment includes an operating room 1, a spray gun 4, an air spray device 2, a feeding device 3 and a recovery device 5; the spray gun 4 is located at the bottom of the operating room 1, and the air spray device 2 includes a Outer sleeve 21, the air jet channel that is located in the sleeve, the injection piece 23 that links to each other with the air jet channel and the blower 24, between this blower fan 24 and the slee...

Embodiment 2

[0039] A medical tablet coating process, comprising the following steps: (1) manufacturing paddle: mixing talcum powder, hydroxypropyl methylcellulose, and nano-scale silicon dioxide in a mixer to prepare paddle, wherein the talc Powder, hydroxypropyl methylcellulose, and nano-scale silicon dioxide are 4:2.5:1.6 in parts by weight; specifically, 40kg of talcum powder, 25kg of hydroxypropylmethylcellulose, and 1.6kg of nano-scale (2) preheating tablet: place the tablet to be coated in the coating equipment, such as Figure 1-7 As shown, the coating equipment includes an operating room 1, a spray gun 4, an air spray device 2, a feeding device 3 and a recovery device 5; the spray gun 4 is located at the bottom of the operating room 1, and the air spray device 2 includes a Outer sleeve 21, the air jet channel that is located in the sleeve, the injection piece 23 that links to each other with the air jet channel and the blower 24, between this blower fan 24 and the sleeve 21 is loc...

Embodiment 3

[0042] A medical tablet coating process, comprising the following steps: (1) manufacturing paddle: mixing talcum powder, hydroxypropyl methylcellulose, and nano-scale silicon dioxide in a mixer to prepare paddle, wherein the talc Powder, hydroxypropyl methylcellulose, and nano-scale silicon dioxide are 3:1.1:0.96 in parts by weight; specifically, 30kg of talcum powder, 11kg of hydroxypropylmethylcellulose, and 9.6kg of nano (2) preheating tablet: place the tablet to be coated in the coating equipment, such as Figure 1-7 As shown, the coating equipment includes an operating room 1, a spray gun 4, an air spray device 2, a feeding device 3 and a recovery device 5; the spray gun 4 is located at the bottom of the operating room 1, and the air spray device 2 includes a Outer sleeve 21, the air jet channel that is located in the sleeve, the injection piece 23 that links to each other with the air jet channel and the blower 24, between this blower fan 24 and the sleeve 21 is located ...

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Abstract

The invention discloses a medical tablet coating process. (1) Manufacture paddle: mix talcum powder, hydroxypropyl methylcellulose, and nano-scale silicon dioxide to prepare paddle; (2) Preheat tablet: put The tablet is placed in the coating equipment, and hot air is sprayed into the coating equipment through the air injection device at the bottom of the coating equipment, and the inside of the coating equipment is heated to heat the tablet; (3) Coating. Hydroxypropyl methylcellulose and nano-scale silicon dioxide are added to the coating of the present invention, which not only makes the coating have good moisture-proof, anti-oxidation, and anti-corrosion characteristics, but also effectively keeps the tablet from being oxidized, damp, and deteriorated. , which greatly improves the stability of the tablet; it can also slow down the release speed of the drug properties of the tablet, and avoid stomach discomfort for the user.

Description

technical field [0001] The invention belongs to the technical field of feed additives, in particular to a medical tablet coating process. Background technique [0002] In the pharmaceutical industry, a layer of coating is usually coated on the outside of the tablet. This layer of coating can protect the tablet, prevent the tablet chip from oxidative deterioration, moisture or volatilization, and can also cover the uncomfortable taste of the chip, so that the tablet is convenient. Identify and alleviate the effects of dissolution and release in the human stomach. [0003] However, the existing coating is usually made of talcum powder, which has poor moisture-proof and anti-oxidation effects, and it is difficult to achieve a good moisture-proof and anti-deterioration effect after the tablet is coated. Moreover, the existing coating process is usually all the coating coating is complete, and then the tablet is dried, which takes a long time and consumes a lot of energy. Cont...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K47/04A61K47/38
CPCA61J3/005Y02P70/10
Inventor 魏建民吴桐赵智勇陈晓盛
Owner 上海国创医药股份有限公司
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