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Clarifying process and quality control method of medicinal composition with function of repairing skin barrier

A quality control method, skin repair technology, applied in the direction of drug combination, medical preparations containing active ingredients, skin diseases, etc., to achieve the effect of repairing the skin barrier

Inactive Publication Date: 2018-04-03
GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] At present, there are no relevant reports at home and abroad that the composition of Baiwei, Lengshuihua, Ginkgo biloba, Huanghuaduoshuilian, Shiya tea and Auranthus clematis extracts are used to repair the skin barrier

Method used

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  • Clarifying process and quality control method of medicinal composition with function of repairing skin barrier
  • Clarifying process and quality control method of medicinal composition with function of repairing skin barrier
  • Clarifying process and quality control method of medicinal composition with function of repairing skin barrier

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Embodiment Construction

[0047] A clarification process and quality control method of a pharmaceutical composition with the effect of repairing the skin barrier of the present invention, the clarification process is carried out according to the following steps:

[0048] Clarification process and content of each component

[0049] (1) Preparation of clarifying agent: Type II ZTC1+1 natural clarifying agent consists of A and B components. Component A: Precisely measure 1.0g of component A, add a small amount of distilled water, stir to form a paste, then add distilled water to prepare 100mL of viscose, swell for 24 hours, and filter with double gauze. Component B: Precisely measure 1.0g of component B, add a small amount of 1% acetic acid solution by volume, stir to form a paste, then add 1% acetic acid solution to make 100mL viscose solution, swell for 24 hours, Filter with double gauze, that is, too.

[0050] (2) Adding order of clarifiers A and B: According to the instructions, ZTC natural clarifie...

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Abstract

The invention discloses a clarifying process and a quality control method of a medicinal composition with the function of repairing skin barrier. The medicine is composed of 6 medicinal materials including radix cynanchi atrati, pilea sinofasciata, folium ginkgo, radix seu herba polygalae fallacis, Adinandra nitida Merr.ex H.L.Li and gemma terminalis anoectochili roxburghii; for the specific clarifying process, a II type ZTC 1+1 natural clarifying agent is adopted for clarifying an extracting solution of the medicinal composition; for the specific quality control method, a thin-layer chromatography method is adopted for carrying out thin-layer identification on radix cynanchi atrati and folium ginkgo in the medicinal composition, and meanwhile, the contents of Hernandulcin, tenuigenin, camelliaside A and kinsenoside in the medicinal composition are measured by adopting a high performance liquid chromatography method. The clarifying process and the quality control method adopted by theinvention have the advantages that the equipment investment is small, the operation process is simple, the defects that in the traditional alcohol precipitation method, the alcohol consumption amountis large, the alcohol recovery is complicated, the measurement for various ingredients of the medicine is complicated, etc., are overcome, the inherent quality, curative effects and stability of the composition are quickly and effectively guaranteed, and the controllability of the quality standard of the medicinal composition is improved.

Description

technical field [0001] The present invention adopts a clarification process of a natural clarifier and a modern analysis and detection instrument to detect traditional Chinese medicine preparations. The technical field relates to a quality control method of a pharmaceutical composition for repairing skin barrier. Background technique [0002] In recent years, with the widespread use of external glucocorticoid preparations, steroid-dependent dermatitis has gradually increased and has become a common disease in dermatology. The disease has the characteristics of polymorphic damage, dependence on hormones, and repeated attacks, which seriously affects the appearance and mental health of patients. Generally speaking, if the strong hormone ointment is used on the face for more than 1.5 months, and the weak or illegal cosmetics containing trace hormones are used for a long time (1-2 years), they will induce hormone-dependent dermatitis locally. Long-term topical use of glucocorti...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P17/00G01N30/90G01N30/02
CPCA61K36/16A61K36/185A61K36/27A61K36/69A61K36/82A61K36/898A61K2236/33A61K2236/53A61K2236/55G01N30/02G01N30/90A61K2300/00
Inventor 王恩瀚陈文龙陈汉坤
Owner GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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