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Cell culture device and method for simulating microgravity-compressive stress joint stimulation

A technology for simulating microgravity and cell culture, which is applied in the field of cell culture devices for simulating microgravity-compressive stress combined stimulation, can solve the problems of a single simulating microgravity environment for a gyrator, and achieve a simple structure, convenient operation, and easy operation Effect

Pending Publication Date: 2018-04-13
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the technical problem that the existing gyrator can only simulate a single microgravity environment, but cannot realize the microenvironment of simulating the change of microgravity compound pressure at the cell level, and provides a method for simulating microgravity- Cell culture device and method for compressive stress combined stimulation

Method used

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  • Cell culture device and method for simulating microgravity-compressive stress joint stimulation
  • Cell culture device and method for simulating microgravity-compressive stress joint stimulation

Examples

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Embodiment 1

[0033] In order to overcome the technical problem that the existing gyrator can only simulate a single microgravity environment, but cannot simulate the change of microgravity composite pressure at the cell level, which is in line with the aerospace microenvironment, this embodiment provides a method such as figure 1 The shown cell culture device for simulating microgravity-compressive stress combined stimulation includes a cell culture unit, a pressure monitoring unit, a microgravity simulation unit and a control unit, and the pressure monitoring unit and the microgravity simulation unit are set in the cell culture On the unit, the pressure monitoring unit and the microgravity simulation unit are electrically connected with the control unit.

[0034] Further, the cell culture unit includes an incubator 4, the incubator 4 is provided with a culture bottle 1 and a liquid storage tank 3, and the culture bottle 1 is connected to the liquid storage tank 3 through the injection pump...

Embodiment 2

[0041]On the basis of Example 1, this embodiment provides a cell culture device for simulating microgravity-compressive stress combined stimulation, further, the inner wall of the incubator 4 is provided with an insulation layer 9, and the insulation A heating wire 10 and a condenser 11 are arranged in the layer 9 , and a temperature sensor 12 is also arranged on the insulation layer 9 , and the heating wire 10 , the condenser 11 and the temperature sensor 12 are all electrically connected to the controller 8 . The temperature sensor 12 monitors the temperature in real time and transmits the signal to the controller 8. When the temperature is too low, the controller 8 controls the heating wire 10 to heat up the temperature. When the temperature is too high or needs to cool down, the controller 8 controls the condenser 11 to cool down. .

[0042] Further, in order to prevent the temperature from being too high, an over-temperature protector is also provided on the thermal insul...

Embodiment 3

[0044] On the basis of Example 1, the present example provides a cell culture device for simulating microgravity-compressive stress combined stimulation, and the incubator 4 is also provided with an illuminating lamp 13 and an ultraviolet disinfection lamp 14, The lighting lamp 13 and the ultraviolet disinfection lamp 14 are arranged above the culture bottle 1 , and the lighting lamp 13 and the ultraviolet disinfection lamp 14 are electrically connected to the controller 8 . Illumination lamp 13 can observe the operation situation in the incubator 4 without opening the device door, and the ultraviolet disinfection lamp 14 can regularly disinfect in the whole incubator 4 by the method of ultraviolet irradiation.

[0045] Further, for the convenience of observation, the incubator 4 is provided with a viewing window. Avoid opening the incubator 4 for bacteria to enter and affect cell culture.

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Abstract

The invention provides a cell culture device and a cell culture method for simulating microgravity-compressive stress joint stimulation. The device comprises a cell culture unit, a pressure monitoringunit, a microgravity simulation unit and a control unit, wherein the pressure monitoring unit and the microgravity simulation unit are arranged on the cell culture unit, and are electrically connected with the control unit. According to the device and the method, pressure in a culture bottle and the rotational microgravity of the culture bottle are controlled for cell culture researches under thecondition of coaction of different pressure stresses such as normal pressure, high pressure or low pressure and a simulated microgravity on cells as well as mechanical effect cell researches in caseof independent action of the normal pressure, the high pressure, the low pressure or the simulated microgravity.

Description

technical field [0001] The invention relates to a cell culture device, in particular to a cell culture device and method for simulating microgravity-compressive stress combined stimulation. Background technique [0002] The shape, structure and function of various physiological systems of the human body have adapted to the normal gravity conditions of the earth. When astronauts enter space, microgravity is a brand-new mechanical environment. The long-term disappearance of gravity will cause the human cardiovascular system, A series of changes in the musculoskeletal system seriously endanger the health of astronauts and hinder the completion of space missions. Therefore, it is necessary to carry out relevant research to explore the biological impact and process of microgravity on the human body, especially to deeply study its mechanism at the cellular and molecular levels, and then propose targeted protective measures. However, due to the limitation of manned spaceflight, it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M1/38C12M1/36C12M1/02
CPCC12M23/08C12M41/00C12M41/12C12M41/40
Inventor 王永春张舒孙喜庆石菲曹新生高原胡泽兵
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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