Cefdinir composition and preparation method thereof
A technology of cefdinir and composition, which is applied in the field of cefdinir composition and preparation thereof, and can solve the problems of poor stability of cefdinir granules, influence on drug safety and the like
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[0023] see figure 1 , the preparation method of the cefdinir granule of one embodiment, comprises the following steps:
[0024] Step S110: mixing the binder, cefdinir, filler and disintegrant to obtain a premix.
[0025] Wherein, binder is povidone. Further, the povidone is selected from one of povidone K12, povidone K15, povidone K17, povidone K25, povidone K30, povidone K60 and povidone K90. Furthermore, the povidone is povidone K30. Specifically, the mass fraction of the adhesive is 2-15 parts. More specifically, the mass fraction of the binder is 3-10 parts.
[0026] Wherein, the mass fraction of propylene glycol is 6-15 parts. Specifically, the mass fraction of propylene glycol is 8-12 parts.
[0027] Among them, the particle size D of cefdinir 90 1 μm to 100 μm. Further, the particle size D of cefdinir 90 10 μm to 70 μm. Specifically, the cefdinir raw material is pulverized by micronization and pulverization technology, and passed through a 100-mesh sieve befor...
Embodiment 1
[0048] The preparation method of the cefdinir composition of the present embodiment is as follows:
[0049] (1) In terms of parts by mass, weigh 100 parts of cefdinir, 660 parts of sucrose, 40 parts of gum arabic, 15 parts of tragacanth gum, 60 parts of dextrin, 60 parts of crospovidone, and 30 parts of povidone K30 60 parts, 60 parts of propylene glycol, 3 parts of orange powder essence, 3 parts of micronized silica gel and 0.1 part of carmine;
[0050] (2) Add cefdinir, sucrose, gum arabic, tragacanth, dextrin, crospovidone, povidone K30 and carmine to the wet granulator for mixing, after mixing evenly, add propylene glycol Carry out granulation to obtain the soft material; then add the soft material to the oscillating granulator and carry out wet granulation through a 30-mesh sieve to obtain wet granules of cefdinir, wherein the granulation time is 180s, and the rotating speed of the stirring paddle is 120rpm, The rotating speed of the cutter is 2100rpm;
[0051] (3) Add ...
Embodiment 2
[0053] The preparation method of the cefdinir composition of the present embodiment is as follows:
[0054] (1) In terms of parts by mass, weigh 100 parts of cefdinir, 680 parts of sucrose, 40 parts of gum arabic, 15 parts of tragacanth gum, 60 parts of dextrin, 80 parts of sodium carboxymethyl starch, and povidone K90 20 parts, 120 parts of propylene glycol, 3 parts of orange powder essence, 3 parts of micronized silica gel and 0.1 part of carmine;
[0055] (2) Add cefdinir, sucrose, gum arabic, gum tragacanth, dextrin, sodium starch glycolate, povidone K90 and carmine into a wet granulator for mixing, after mixing evenly, add propylene glycol for Granulating to obtain the soft material; then adding the soft material to the oscillating granulator and passing through a 30-mesh sieve for wet granulation to obtain wet granules of cefdinir, wherein the granulation time is 300s, the rotating speed of the stirring paddle is 240rpm, and the cutting The rotation speed of the knife i...
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