Preparation method of compound musk injection

A technology for injection and musk, which is applied to medical preparations without active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve the side effects of compound musk injection, the injection stability is not good enough, and the water solubility is poor. problem, to achieve the effect of low toxicity and side effects, good use effect, good dispersibility and stability

Inactive Publication Date: 2018-04-27
安徽金太阳生化药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the poor water solubility of the main active ingredients such as borneol and menthol, the stability of the injection prepared by conventio

Method used

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Examples

Experimental program
Comparison scheme
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Example Embodiment

[0016] A preparation method of compound musk injection includes the following steps:

[0017] (1) Add 2kg of artificial musk, 25kg of patchouli, 25kg of turmeric and 25kg of Shichangpu into water equivalent to 8 times the total weight of the medicinal materials. Steam distillation is equivalent to 4 times the total weight of the medicinal materials to obtain the first distillate. Re-distill to 2.5 times the total weight of medicinal materials, and refrigerate the obtained re-distilled liquid for later use;

[0018] (2) Add 0.2kg of borneol and 0.15kg of menthol to 20kg of absolute ethanol to dissolve evenly, then add 0.5kg of stearic acid and stir at 50℃ for 3min, then slowly add 5kg of polysorbate-80 and 250kg of water for injection Stir the mixture evenly at high speed, firstly distill under reduced pressure to remove ethanol, and then homogenize and emulsify under high pressure to obtain composite nanoemulsion;

[0019] (3) Mix the redistilled liquid obtained in step (1) with the...

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Abstract

The invention discloses a preparation method of a compound musk injection. The method includes the steps of: 1) performing primary distillation and re-distillation to artificial musk, pogostemon cablin, curcuma aromatica and rhizoma acori graminei to obtain a re-distilled liquid, and refrigerating the re-distilled liquid for later use; 2) uniformly mixing and dissolving borneol, menthol and stearic acid in anhydrous ethanol, slowly adding the mixture to a mixed liquid of polysorbate-80 and water for injection, and performing high-speed stirring, pressure reduced distillation and high-pressurehomogenizing emulsification to obtain composite nano emulsion; and 4) mixing the re-distilled liquid with the composite nano emulsion, adding active carbon, refrigerating the mixture overnight, removing the active carbon through coarse filtration with a titanium rod, and filtering, encapsulating and sterilizing the product, performing light inspection, and packaging and storing the product. The compound musk injection is good in dispersibility and stability, is low in toxic and side effects and has good application effect.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of compound musk injection. Background technique [0002] The main ingredients of compound musk injection include artificial musk, turmeric, patchouli, calamus calamus, borneol, and menthol. treat. At present, the preparation method of compound musk injection is to collect the red distillate after initial distillation and redistillation of artificial musk, patchouli, turmeric, and calamus, dissolve borneol and menthol with the double distillate, and then use water for injection to dissolve the compound musk injection. Diluted, filtered and sterilized. However, due to the poor water solubility of the main active ingredients such as borneol and menthol, the stability of the injection prepared by conventional methods is not good enough; and the ingredients such as borneol have certain toxicity, and the obtained compound musk injection has c...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/08A61K47/12A61K47/26A61K9/107A61P9/10A61P25/00A61K35/55A61K31/045
CPCA61K9/0019A61K9/08A61K9/1075A61K31/045A61K35/55A61K36/532A61K36/888A61K36/9066A61K47/12A61K47/26A61K2236/331A61K2300/00
Inventor 徐三能强泽明
Owner 安徽金太阳生化药业有限公司
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