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Application of diallyl disulfide in preparing medicine for preventing and/or treating hyperlipemia

A diallyl disulfide, hyperlipidemia technology, applied in the field of medicine

Inactive Publication Date: 2018-05-11
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Whether diallyl disulfide is the lipid-lowering component in garlic oil has not been reported

Method used

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  • Application of diallyl disulfide in preparing medicine for preventing and/or treating hyperlipemia
  • Application of diallyl disulfide in preparing medicine for preventing and/or treating hyperlipemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0020] 1 Materials and methods

[0021] 1.1 Materials

[0022] 1.1.1 Main reagents and instruments

[0023] DADS (CAS 2179-57-9) was purchased from Shandong West Asia Chemical Co., Ltd., TC, TG, HDL-C and LDL-C kits were purchased from Ningbo Meikang Biotechnology Co., Ltd., and lard was purchased from the market. Beckman AU480 automatic biochemical analyzer, multifunctional refrigerated horizontal centrifuge (Heraeu Biofuge Stratos), pipette (Eppendorf), Milli-Q ultrapure water system.

[0024] 1.1.2 Model Feed

[0025] Add 20.0% sucrose, 15% lard, 1.2% cholesterol, 0.2% sodium cholate, appropriate amount of casein, calcium hydrogen phosphate and stone powder to the maintenance feed to make model feed.

[0026] 1.2 Method According to the "Assessment Method for Auxiliary Blood Lipid Lowering Function" approved by the State Food and Drug Administration Baohua [2012] No. 107

[0027] 1.2.1 Grouping and handling of experimental animals

[0028] 40 Wistar male rats, weighing...

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Abstract

The invention belongs to the field of medicines, and concretely relates to application of diallyl disulfide in preparing a medicine for preventing and / or treating hyperlipemia. Experimental results prove that the diallyl disulfide can be beneficial to reducing serum TC, TG and LDL-C of hyperlipemia rats, and increasing HDL-C; all differences are statistically significant (p is less than 0.05). According to a criterion of a blood lipid reduction auxiliary function evaluation method in the attachment 6 of <Notice About Issuing Nine Health Food Function Evaluation Methods Containing Antioxidant Function Evaluation Method> (SFDA [2012] No.107) issued by state food and drug administration, DADS has a blood lipid reduction auxiliary function. Therefore, the diallyl disulfide has a lipid reducingeffect and has clinical significance on treating and preventing hyperlipemia.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of diallyl disulfide in the preparation of drugs for preventing and / or treating hyperlipidemia. Background technique [0002] Hyperlipidemia is a systemic disease in which one or more lipids in plasma are higher than the normal range due to abnormal fat transport or metabolism. Typically total cholesterol (TC) and / or triglycerides (TG). Hyperlipidemia causes some diseases that seriously endanger human health, especially cardiovascular and cerebrovascular diseases, such as coronary heart disease and atherosclerosis. However, there is still a lack of specific drugs for the treatment of hyperlipidemia in the pharmaceutical market at present, and Western medicines are mainly used for treatment, such as bile acid sequestrants, hydroxymethylglutaryl-CoA reductase inhibitors, and phenoxyacetic acid lipid-lowering drugs. The above Western medicines often have poor th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/105A61P3/06A23L33/105
CPCA23L33/105A23V2002/00A61K31/105A23V2200/326A23V2250/212
Inventor 谢克勤王琼
Owner SHANDONG UNIV
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