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Application of teruzhenin and its composition and pharmaceutical preparation in lipid-lowering

A technology of privetin and its composition, applied in the field of application of privetin and its composition and pharmaceutical preparations in lipid-lowering

Active Publication Date: 2018-10-23
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report on the lipid-lowering effect of tervinitin

Method used

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  • Application of teruzhenin and its composition and pharmaceutical preparation in lipid-lowering
  • Application of teruzhenin and its composition and pharmaceutical preparation in lipid-lowering
  • Application of teruzhenin and its composition and pharmaceutical preparation in lipid-lowering

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: The lipid-lowering effect of teruzhengside

[0023] Experimental Animals and Methods

[0024] C57BL mice, SPF grade, male, body weight (20±2) g, were randomly divided into two groups, the first group of 14 was the normal control group, given normal feed, and the remaining mice (34) were used to produce high-fat mice. The models were given high-fat feed (20% lard, 1.25% cholesterol, and 0.5% sodium cholate were added to the basic feed), and they were free to eat and drink. After 8 weeks of continuous feeding, 4 mice were sacrificed from the normal control group and the model mice respectively, and the serum and liver biochemical indicators of the two groups of mice, as well as the pathological sections of liver tissue, were compared to determine whether the model was established successfully. 30 mice successfully modeled were randomly divided into 3 groups, the model group (10 mice), the teruzhenin group (10 mice), and the positive control group (10 mice in...

Embodiment 2

[0042] Example 2: Lipid-lowering effect of combination of tergumin and lovastatin

[0043] After the animal experiment confirmed the lipid-lowering effect of privetin, the inventors continued to study whether tervetin has a synergistic lipid-lowering effect with lovastatin, a lipid-lowering drug commonly used in clinical practice. The liver is an organ for lipid synthesis. We starved the hepatocytes (LO2) for 6 hours, and then treated them with drugs for 18 hours. The lipid content in the hepatocytes was used as the drug efficacy index.

[0044] The determination method of cholesterol and triglyceride content in cells is as follows:

[0045] The content of cholesterol and triglyceride in hepatocytes was determined by the cell and tissue cholesterol and triglyceride assay kit of Beijing Pulilai Gene Technology Co., Ltd. The specific steps are as follows:

[0046] (1) Discard the supernatant, rinse twice with PBS, and digest with trypsin at 37°C for 2 minutes.

[0047] (2) A...

Embodiment 3

[0064] Embodiment 3: formulation example

[0065] Teruvirin Tablets

[0066] 10mg of privetin, 88g of starch, 3g of magnesium stearate.

[0067] Preparation process: take privetin, mix with starch and magnesium stearate evenly, make granules, dry, and compress into tablets.

[0068] Tetravirin Capsules

[0069] 10mg of privetin, 88g of starch, 3g of magnesium stearate.

[0070] Preparation process: take privetin, mix with starch and magnesium stearate evenly, make granules, dry, pack into capsules, and obtain.

[0071] Teruzhenin Injection

[0072] 47mg of privetin and 7mg of sodium chloride for injection.

[0073] Preparation process: Dissolve privetin with 1.9mL water for injection, add sodium chloride for injection to isotonicity, adjust the pH value to 7-7.1, filter, refrigerate for 24 hours, add water for injection to the specified amount, filter, Potting, sterilization, that is.

[0074] Combination Tablets of Teruzhengside and Lovastatin

[0075] 10mg of prive...

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Abstract

The invention discloses an application of specnuezhenide, a composition and a medicinal preparation thereof in lipid reduction. A lipid reduction medicine includes an active component specnuezhenide and also may include lovastatin, and also includes a pharmaceutically acceptable carrier or excipient. The lipid reduction medicine is processed into any pharmaceutically acceptable dosage forms. In the invention, it is proved that the specnuezhenide has the function of reducing lipid, including reducing blood lipid and liver fat; the specnuezhenide can be combined with the lovastatin to achieve better effects since there is synergistic effects among the two components. The medicine can be used for treating hyperlipoidemia and non-alcoholic fatty liver disease.

Description

technical field [0001] The invention belongs to the field of medicaments and relates to new uses of medicaments, in particular to the application of teruzhenitin and its composition and pharmaceutical preparations in lipid-lowering. Background technique [0002] The main blood lipid components in plasma include cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c). Among them, low-density lipoprotein is the chief culprit of vascular obstruction, coronary heart disease and stroke, so it is called "bad cholesterol". HDL transports LDL from the blood back to the liver, lowering the level of LDL in the blood and preventing it from depositing on the walls of blood vessels. HDL can also carry 1 / 4-3 / 4 of the cholesterol in the blood. In addition, HDL may also move excess cholesterol away from atherosclerotic plaque, so it is called "good cholesterol." [0003] Hyperlipidemia refers to a series of disease...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/366A61K31/22A61P3/06A61P1/16
CPCA61K31/22A61K31/366A61K31/7048A61K2300/00
Inventor 薛文华赵杰田鑫梁淑红李砺锋周霖姚道珂
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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