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Sealant hydrogel, kit and preparation method of sealant hydrogel

A technology of hydrogel and sealant, which is applied in the field of biomedicine, can solve the problems such as the need to improve the adhesion, and achieve the effect of avoiding the risk of disease transmission, simple preparation method, and avoiding secondary surgery

Active Publication Date: 2018-05-11
沈伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many ways to prepare fast, shapeable gels, their adhesion needs to be improved

Method used

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  • Sealant hydrogel, kit and preparation method of sealant hydrogel
  • Sealant hydrogel, kit and preparation method of sealant hydrogel
  • Sealant hydrogel, kit and preparation method of sealant hydrogel

Examples

Experimental program
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Embodiment 1

[0053] Example 1: Preparation of sealant hydrogel

[0054] 1. Preparation method

[0055] According to the various components and parameters shown in Table 1, the first component was dissolved in an acidic buffer to obtain solution I, the second component was dissolved in an alkaline buffer to obtain solution II, and the third component was dissolved in an alkaline buffer to obtain solution II. in acidic buffer with the addition of NaIO 4 to obtain solution III. The solutions I, II and III are mixed and cross-linked, and the surgical sealant hydrogel of the present invention can be rapidly formed in situ at room temperature, and the specific gelation time is shown in Table 1; in addition, the solutions I and II are mixed. Ordinary cross-linked hydrogels can also be formed.

[0056] Wherein in the above preparation method, the preparation method of the third component four-arm polyethylene glycol dopamine (4-arm-PEG-DA) is as follows: Weigh 0.5 mmol four-arm polyethylene gly...

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Abstract

The invention provides sealant hydrogel, a kit and a preparation method of the sealant hydrogel. The preparation method of the sealant hydrogel is simple. On the basis of common two-component hydrogel, a chemically modified polyethylene glycol macromonomer is added, and during use, the hydrogel with certain adhesive force is rapidly produced in situ after mixing. The produced hydrogel has good biocompatibility, bioadhesion, biodegradability and adjustable degradation performance, gelation time of the hydrogel is greatly shortened, important indexes such as gel content, swelling rate and the like are substantially increased, and degradation speed can be adjusted according to needs of application occasions. The sealant hydrogel can have important clinical value in the medical field, especially when used as a surgical sealant.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a sealing agent hydrogel, a kit and a preparation method thereof. Background technique [0002] Surgical sealant, as a medical material to replace surgical sutures, can be used in closed hemostasis fields such as body surface, internal organs, cardiovascular and brain surgery. It can effectively shorten the operation time, improve the success rate of the operation, and reduce the operation time It is a safe and effective treatment for patients and doctors. The ideal surgical sealant must meet the following conditions: good compatibility with tissues, can be metabolized or biodegraded by the body, have good bioadhesion, can quickly form a film at room temperature and solidify to form a water-insoluble sealant. Membrane etc. [0003] Natural mussels tend to have strong adhesion, and mussel-based biomimetic adhesives have been potential biomedical materials. Studies have shown that the...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/04C08J3/075C08J3/24C08L71/02C08L79/02
CPCA61L24/001A61L24/0031A61L24/043C08J3/075C08J3/246C08J2371/02C08J2471/02C08J2479/02C08L71/02C08L79/02
Inventor 沈伟伍国琳单萌
Owner 沈伟
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