Improved blood flow imaging method by using laser speckles as contrast

A technology of laser speckle and imaging method, which is applied in the field of blood flow imaging and can solve the problems of small dynamic range and reduced signal-to-noise ratio.

Active Publication Date: 2018-05-18
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

[0003] Although many laser speckle contrast analysis methods have been proposed, the imaging principles of these algorithms are similar in nature, and they all use probability and statistics to obtain contrast values.
Considering that the existing speckle imaging technology has a small dynamic range, and the signal-to-noise ratio is reduced due to the influence of heartbeat, breathing and other noises, the present invention proposes an improved laser speckle contrast blood flow imaging method, This method combines the three algorithms of interpolation, decorrelation and standard deviation to effectively improve the dynamic range of the speckle blood flow image and reduce the impact of noise such as heartbeat and respiration on it.

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  • Improved blood flow imaging method by using laser speckles as contrast
  • Improved blood flow imaging method by using laser speckles as contrast

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[0041] Example: Improved Laser Speckle Contrast Blood Flow Imaging in the Ear of Female Nude Mice

[0042] The laser speckle imaging system collected 80 frames of images for the middle and lower left positions of the ears of nude mice respectively.

[0043]Select 80 frames of original speckle images in the middle of the ears of nude mice, and use the improved laser speckle contrast blood flow imaging algorithm to process them. Affected by the respiration and heartbeat of the nude mice, the ears of the nude mice will vibrate weakly, resulting in the formation of biological tissues. One moves at a low speed, while blood flow has a higher speed relative to the tissue. When the speed is low, the standard deviation is high, and when the speed is high, the standard deviation is low, so the overall background of the blood flow image obtained by the iLSCA algorithm is brighter, and the blood flow part is darker. Such as image 3 Shown:

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Abstract

The invention discloses a method for blood flow imaging, in particular to an improved blood flow imaging method by using laser speckles as a contrast. The method for blood flow imaging includes the steps of performing data acquisition on a target; performing interpolating on an original speckle image, and then performing decorrelation and standard deviation processing on the interpolated image toobtain a blood flow image. According to the technical scheme above, the influence of static speckles on the image is reduced through a decorrelation algorithm, jitter noise caused by respiratory heartbeats of an animal is effectively reduced, the image resolution is improved, especially the identification degree of small vessels is increased, and an effective detection method can be provided for future research on new vessels or hyperplastic vessels.

Description

technical field [0001] The invention relates to a blood flow imaging method. In particular, it relates to an improved laser speckle contrast blood flow imaging method. Background technique [0002] Laser speckle contrast imaging technology was first proposed in the 1980s, and has since been gradually applied to biomedical blood flow monitoring. The essence of the laser speckle phenomenon is the interference phenomenon formed by the reflection or transmission of the surface of the rough object irradiated by the laser. The speckle particles in it contain the motion information of the measured object, and the speckle field will follow the moving elements in the measured biological tissue. Such as changes in blood flow or structural state to produce corresponding changes. Briers and Webster pointed out that the statistical characteristics of the temporal and spatial changes of the speckle image contain the motion information of the measured material, and because of the randomn...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/026
CPCA61B5/0261A61B5/72A61B5/7203
Inventor 王立伟李跃杰李易陆
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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