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A kind of preparation method of cpc sodium salt

A technology of sodium salt and organic solvent is applied in the field of preparation of CPC sodium salt, which can solve the problems of insufficient purity of CPC sodium salt, affecting the quality of cephalosporins, etc., and achieve the effects of low cost and simple operation.

Active Publication Date: 2021-04-02
YILI CHUANNING BIOTECH CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the purity of CPC sodium salt is not high enough, which will affect the quality of cephalosporins prepared from it

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, the preparation of CPC sodium salt of the present invention

[0023] Take 50L of CPC feed solution with a potency of 21500u / ml, and further concentrate it to 10L with a potency of 96300u / ml on a nanofiltration concentrator in the laboratory. The concentrated solution was adjusted to neutral pH with 4% sodium hydroxide solution,

[0024] Use Rohm and Haas FPA-65 ion exchange resin to decolorize the concentrated solution in a dynamic decolorization mode (resin loading capacity is 1.4L, feed flow rate is 2BV / h, decolorization process temperature is 0-5°C), and the decolorization solution uses G4 Sand core funnel filter. Slowly add 30L of acetone to the filtered decolorizing solution at 5°C for crystallization at a feeding rate of 2BV / h. The cake was washed twice with acetone and drained to obtain 832 grams of CPC sodium salt crude product.

[0025] Add 8L of purified water to dissolve the dried crude CPC sodium salt, and use Rohm and Haas FPA-65 exchange r...

Embodiment 2

[0026] Embodiment 2, the preparation of CPC sodium salt of the present invention

[0027] Take 60L CPC nanofiltration concentrate with a potency of 22500u / ml, and further concentrate it to 13L with a potency of 92763u / ml on a nanofiltration concentrator in the laboratory. The concentrated solution is adjusted to neutral pH with 4% sodium hydroxide solution, and the concentrated solution is decolorized in a dynamic decolorization mode using Rohm and Haas FPA-65 ion exchange resin (resin loading capacity 1.3L, feed flow rate is 1BV / h , the decolorization process temperature is 0-5°C), and the decolorization solution is filtered with a G4 sand core funnel. Slowly add 30L of acetone to the filtered decolorizing solution at 5°C for crystallization at a feeding rate of 2BV / h. The cake was washed twice with acetone and drained to obtain 950 g of the crude product of CPC sodium salt.

[0028] Add 1.5L of purified water to dissolve 150g of the dried CPC sodium salt crude product, and...

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PUM

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Abstract

The invention provides a CPC (cephalosporin C) sodium salt preparation method which includes the steps: (1) primary crystallization: concentrating CPC feed liquid, discoloring the feed liquid by ion exchange resin and crystallizing the feed liquid in an organic solvent to obtain a CPC sodium salt crude product; (2) secondary crystallization: taking the CPC sodium salt crude product obtained in thestep (1), dissolving the CPC sodium salt crude product by distilled water, discoloring the CPC sodium salt crude product by the ion exchange resin and crystallizing the CPC sodium salt crude productin the organic solvent to obtain CPC sodium salt. The CPC feed liquid serves as a raw material, and crystallization is performed twice by the steps of concentration, discoloration, crystallization andthe like to obtain the high-purity CPC sodium salt. The method is simple in operation and low in cost, and the high-purity CPC sodium salt can be simply and effectively obtained.

Description

technical field [0001] The invention relates to a preparation method of CPC sodium salt. Background technique [0002] Cephalosporin C, referred to as CPC, belongs to the β-lactam antibiotics and is active against Staphylococcus aureus, Salmonella typhi and Escherichia coli. However, due to its low antibacterial activity, it has not been widely used clinically. However, using cephalosporin C as the starting material, two major β-lactam cephalosporins, 7-aminocephalosporanic acid (7-ACA) and 7-aminodesacetoxycephalosporanic acid (7-ADCA), can be obtained. After chemical modification, dozens of commonly used cephalosporins can be produced. The toxicity of this type of drug is far lower than that of penicillin. . [0003] At present, cephalosporin nuclei can be produced by biological fermentation, 6-aminopenicillanic acid (6-APA) ring expansion or penicillin expansion, wherein biological fermentation is the most environmentally friendly production method for preparing cephal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D501/28C07D501/12
CPCC07D501/12C07D501/28
Inventor 张亚勇张云辉蔡黎明努尔买买提·库达巴尔地臧静吕占亮王喜春包蕾那扎尔拜·伯拉提张芳芳杜刚胡晓非
Owner YILI CHUANNING BIOTECH CO