Preparing method of absorbent hemostatic dressing with high liquid absorbing capability
A hemostatic dressing and absorbent technology, which is applied in the field of preparation of absorbent hemostatic dressings, can solve the problems of the hemostatic dressing's unsatisfactory liquid absorption ability and unfavorable wound healing, etc.
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Embodiment 1
[0023] The absorbent hemostatic dressing with high liquid absorption capacity of this embodiment has a three-layer structure, which is sequentially composed of a bioabsorbable film, an absorption enhancement layer, and a bioabsorbable porous material layer.
[0024] Its preparation method is as follows:
[0025] (1) Preparation of the bioabsorbable film: Weigh 20g of gelatin particles and grind them into powder, dissolve them in water, make a colloidal liquid with a mass fraction of 0.5% to 10%, add 5g of sodium alginate, and stir evenly Finally, pour it on a glass or stainless steel plate, cast it into a film, and dry it at room temperature to obtain the film-like bioabsorbable film;
[0026] (2) Preparation of the absorption-enhancing layer: Melt glyceric acid and lactide into water at a mass ratio of 1:1, stir evenly, then perform high-temperature polymerization at a high temperature of 300°C, and then naturally cool to obtain a mixed material, which will be obtained The m...
Embodiment 2
[0030] The absorbent hemostatic dressing with high liquid absorption capacity of this embodiment has a three-layer structure, which is sequentially composed of a bioabsorbable film, an absorption enhancement layer, and a bioabsorbable porous material layer.
[0031] Its preparation method is as follows:
[0032] (1) Preparation of the bioabsorbable film: take 20g of collagen particles and grind to powder, dissolve it in water, make a colloidal liquid with a mass fraction of 0.5% to 10%, add 5g of sodium alginate, and stir After uniformity, it is poured on a glass or stainless steel plate, cast to form a film, and dried at room temperature to obtain the film-like bioabsorbable film;
[0033] (2) Preparation of the absorption-enhancing layer: Melt glyceric acid and lactide into water at a mass ratio of 1:3, stir evenly, then perform high-temperature polymerization at a high temperature of 300°C, and then naturally cool to obtain a mixed material, which will be obtained The mixe...
experiment example
[0037] For verifying the technical effect of absorbable hemostatic dressing of the present invention, carry out following wound healing experiment:
[0038] Take 10 healthy adult rabbits, divide them into 2 groups, 5 in each group, record as Example 1 group and Example 2 group, intravenous anesthesia, fix them on the operating table, remove the hair at the back and femoral groove, and scratch the body surface Medium and small blood vessels were respectively covered with the rapid hemostatic wound dressings of Embodiment 1 and Embodiment 2 of the present invention, and pressed manually for 15-60s. Observe the hemostasis time and 7 days after operation.
[0039] It can be known from the experimental results that the hemostasis time of the tested animals is different due to the different bleeding sites. But 7 days after the operation, using the absorbable hemostatic dressing of the present invention, the wounds of the tested animals were all well healed, and the limbs could move...
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Abstract
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