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Preparation method of fructus xanthii nasal drops

A technology of cocklebur and nasal drops, applied in the field of preparation of cocklebur nasal drops, can solve the problems of insufficient extraction of active substances of cocklebur, easy breeding of bacteria, influence on drug efficacy, etc. The effect of mass production, easy control and low production cost

Inactive Publication Date: 2018-05-29
河南明珍方医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] When used to prevent or treat rhinitis, cocklebur seeds are often mashed by hand, added with sesame oil, boiled with a slow fire, absorbed with a cotton swab, and then applied to the nasal cavity. Although the hand-made medicinal oil is effective, the Medicinal oil is not easy to store, it is easy to breed bacteria and deteriorate, and it is inconvenient to use as it is prepared and used immediately
On the other hand, only soaking in sesame oil can not fully extract the active substances of cocklebur, which will affect the efficacy of the medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The following method is used to prepare cocklebur nasal drops:

[0021] (1) Wash about 50 cocklebur seeds, put them in a drying oven, set the drying oven at 100-105°C, and dry for about 7 minutes;

[0022] (2) Put the dried cocklebur seeds into a wok and stir-fry for 10 minutes until the surface is dark yellow, remove the thorns, crush and grind them into powder, and pass through a 30-mesh sieve;

[0023] (3) Add 20g Xanthizi powder into 50mL absolute ethanol, sonicate in an ultrasonic chamber for 20min, filter, concentrate the filtrate until it has no alcohol smell, and obtain about 15g of oil;

[0024] (4) Add 15g of oily substance to 15g of sesame oil, heat and stir at 55°C for 20 minutes, sterilize in steam flow at 110°C for 20 minutes, cool, and package to obtain Xanthizi nasal drops.

Embodiment 2

[0026] The following method is used to prepare cocklebur nasal drops:

[0027] (1) Wash about 50 cocklebur seeds, put them in a drying oven, set the drying oven at 100-105°C, and dry for about 5 minutes;

[0028] (2) Put the dried cocklebur seeds into a wok and stir-fry for 15 minutes until the surface is dark yellow, remove the thorns, crush and grind them into powder, and pass through a 30-mesh sieve;

[0029] (3) Add 20g Xanthizi powder into 50mL isopropanol, sonicate in an ultrasonic chamber for 25 minutes, filter, concentrate the filtrate until it has no alcohol smell, and obtain about 12g of oil;

[0030] (4) Add 12g of oily substance to 18g of olive oil, heat and stir at 60°C for 20 minutes, sterilize in steam flow at 110°C for 20 minutes, cool, and package to obtain Xanthium nasal drops.

[0031] In about 200 patients with rhinitis, the effective rate was 86% (relief of rhinitis symptoms was considered effective), and 13 patients insisted on using it for more than one...

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PUM

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Abstract

The invention relates to a preparation method of fructus xanthii nasal drops. The preparation method comprises the following steps of (1) cleaning and drying fructus xanthii; (2) putting the dried fructus xanthii in a wok for stir frying, crushing and grinding the stir-fried fructus xanthii into powder; (3) adding the fructus xanthii powder in an alcohol solvent, performing ultrasonic treatment, and performing filtration to enable a filtrate to be concentrated; and (4) adding a concentrate in vegetable oil, and performing stirring with heating, sterilization, cooling and packaging to acquire the fructus xanthii nasal drops. The invention also relates to the fructus xanthii nasal drops prepared by the preparation method. The preparation method provided by the invention improves the preparation process of the fructus xanthii nasal drops, replaces a manual preparation method and is more suitable for mass production; and is simple in compatibility, liable to control, high in safety coefficient, low in production cost and convenient to use by adopting a single medicine.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a preparation method of cocklebur nasal drop. Background technique [0002] Xanthium aliases: lice horse head, old sky, Taoist head, thorn eight naked, Canglangzi, Miancang prodigal son, Qiangzi naked son, green spines, snatching son, idiot, Hu Cuizi, wild eggplant, pig's ear, vegetable Ear, belonging to the genus Asteraceae and Xanthium, is the fruit of the involucre of the annual herb Asteraceae Xanthium. Xanthium is a commonly used Chinese herbal medicine. Orifice drug compatibility, for the treatment of rhinitis. [0003] When used to prevent or treat rhinitis, cocklebur seeds are often mashed by hand, added with sesame oil, boiled with a slow fire, absorbed with a cotton swab, and then applied to the nasal cavity. Although the hand-made medicinal oil is effective, the Medicinal oil is not easy to store, and it is easy to breed ...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P11/02A61K131/00
CPCA61K36/28A61K9/0043A61K2236/13A61K2236/15A61K2236/17A61K2236/333
Inventor 司会贞
Owner 河南明珍方医药科技有限公司