Ultrasound drug assisted treatment device

[0027] The present invention will be further described below in conjunction with the accompanying drawings of the specification.

[0028] The ultrasonic medicine auxiliary treatment device of the present invention includes an integrated ultrasonic excitation pulse generating circuit, an electroporation pulse generating circuit, an electrical stimulation signal generating circuit and a single-chip microcomputer,

[0029] Such as figure 1 As shown, the ultrasonic excitation pulse generating circuit includes an active crystal oscillator M1, a push-pull amplifier circuit, a first strobe circuit, and an ultrasonic transducer H1. The active crystal oscillator M1 sequentially passes through the push-pull amplifier circuit and the first selection The communication circuit is connected to the ultrasonic transducer H1, and the first strobe circuit is connected to the first control signal output terminal of the single-chip microcomputer, and is used to control the operation or stop of the ultrasonic transducer H1,

[0030] The push-pull amplifier circuit includes a transistor T1, a transistor T2, and a MOS transistor Q1. The output terminal of the active crystal oscillator M1 is connected to the base of the transistor T1, and the collector of the transistor T1 is connected to the first voltage terminal VCC1 ( It can be connected to a DC 5V), the emitter of the transistor T1 is connected to the emitter of the transistor T2 and the gate of the MOS transistor Q1, and the drain of the MOS transistor Q1 is connected to the second voltage terminal VCC2 ( It can be DC 12V) connected, the collector of the transistor T2 is connected to ground, the source of the MOS transistor Q1 is connected to ground, and the drain of the MOS transistor Q1 is also connected to the first gate through a capacitor C2 The circuit is connected, the transistor T1 is an NPN transistor, and the transistor T2 is a PNP transistor,

[0031] The frequency of the active crystal oscillator M1 is 1 MHz, and the ultrasonic transducer H1 can output an ultrasonic excitation pulse signal of 1.0 MHz±10%, which can realize an ultrasonic introduction method to the skin.

[0032] Such as figure 2 As shown, the electroporation pulse generating circuit includes a power plug J1, a transformer T4, a rectifier bridge circuit VD1, a filter capacitor C1, and a second gating circuit. The power plug J1 is connected to the mains through the transformer T4 and the rectifier bridge The input terminal of the circuit VD1 is connected, the output terminal of the rectifier bridge circuit VD1 is connected with the second gate circuit, the filter capacitor C1 is connected in parallel with the output terminal of the rectifier bridge circuit VD1, and the second gate circuit is connected to the single-chip microcomputer. Is connected to the second control signal output terminal of the rectifier bridge circuit VD1 for controlling the output of electroporation pulse or stopping the output of electroporation pulse, the pulse peak voltage of electroporation pulse is 87V±10%, and the pulse width is 0.2S ±10%, which can realize electroporation to the skin, such as image 3 As shown, the electrical stimulation signal generation circuit includes an RC oscillator circuit, a half-wave rectifier circuit, and a third gating circuit. The RC oscillator circuit is connected to the half-wave rectifier circuit to form a sinusoidal half-wave electrical stimulation signal. The connection between the RC oscillator circuit and the half-wave rectifier circuit is connected to a third gating circuit, and the third gating circuit is connected to the third control signal output terminal of the single-chip microcomputer, and is used to control the sine half-wave electrical stimulation signal Output or stop output, the RC oscillator circuit includes an operational amplifier U1, the half-wave rectifier circuit includes a rectifier diode D1, a rectifier diode D2,

[0033] The non-inverting input terminal of the operational amplifier U1 is connected to ground through a resistor R2, the inverting input terminal of the operational amplifier U1 is connected to ground through a resistor R3, and the inverting input terminal of the operational amplifier U1 also passes through The potentiometer RP1 and the resistor R4 are commonly connected with the anode of the rectifier diode D1 and the rectifier diode D2. The cathode of the rectifier diode D1 and the anode of the rectifier diode D2 are connected to the output terminal of the operational amplifier U1. The output of the operational amplifier U1 The terminal is also connected to ground through a capacitor C3, a resistor R5, and a capacitor C4 in turn. The output terminal of the operational amplifier U1 is also connected to the anode of the diode D3, and the cathode of the diode D3 is connected to the ground through a resistor R6. The cathode of the diode D3 is connected to the third gate circuit. The cathode of the diode D3 outputs a sine half-wave electrical stimulation signal. The electrical stimulation signal is a modulated signal. Its fundamental wave is 2KHZ±10% and pulse width is 0.25mS± The 10% square wave is generated by an RC oscillator circuit, and the modulated sine half-wave electrical stimulation signal is a pulsating sine half-wave signal with a frequency of 100HZ±10%.

[0034] Preferably, the operational amplifier U1 is an LM324 operational amplifier.

[0035] Preferably, such as figure 1 , figure 2 As shown, the first gating circuit and the second gating circuit respectively include a relay K1 and a relay K2. The coils of the relay K1 and the relay K2 are respectively connected to the corresponding control signal output terminals of the single-chip microcomputer. The electric shock switch is connected in series between the push-free amplifier circuit and the ultrasonic transducer H1; the electric shock switch of the relay K2 is connected in series with the positive output end of the rectifier bridge circuit VD1; image 3 As shown, the third gate circuit includes a resistor R7 and a transistor T3. One end of the resistor R7 is connected to the cathode of the diode D3, and the other end of the resistor R7 is connected to the collector of the transistor T3. The collector of the transistor T3 is connected to the corresponding control signal output terminal of the single-chip microcomputer, the collector and emitter of the transistor T3 is connected to the ground, and the base of the transistor T3 is used as the output terminal of the electrical stimulation signal generating circuit for output Or stop the output of the sine half-wave electrical stimulation signal, so as to realize the use of ultrasonic excitation pulse, electroporation pulse, and electrical stimulation signal through the single-chip microcomputer as needed.

[0036] In summary, the ultrasonic drug-assisted treatment device of the present invention integrates ultrasonic excitation pulses, electroporation pulses, and electrical stimulation signals, and selects ultrasonic excitation pulses, electroporation pulses, and electrical stimulation signals through a single-chip microcomputer as required It can be used in conjunction to improve the penetration effect of drug use, so that the human body part or the whole body can be better treated, the circuit is ingenious, easy to realize, and has a good application prospect.

[0037] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the industry should understand that the present invention is not limited by the foregoing embodiments. The foregoing embodiments and descriptions only illustrate the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have Various changes and improvements, these changes and improvements fall within the scope of the claimed invention. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.