Online detection device for drug preparation process
A technology of preparation process and detection device, applied in Raman scattering, material excitation analysis and other directions, can solve the problems of narrowing the detection range, weak Raman scattering signal, increasing detection difficulty, etc., and achieves high accuracy and efficient detection process. , the effect of reducing the error
Inactive Publication Date: 2018-06-29
SUZHOU EUROPOD PRECISION INSTR TECH CO LTD
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Problems solved by technology
However, one of the main limitations of the application of Raman spectroscopy is that the Raman scattering signals obtained from micro-trace chemical substances are very weak, which reduces the applicable range of its detection and increases the difficulty of detection.
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Embodiment 1
[0024] see Figure 1-3 , an on-line detection device for a drug preparation process of the present invention includes a reaction kettle, an injection device, a Raman spectrum detection system and a controller.
[0025] The reaction kettle includes a kettle body 1 , and the kettle body 1 is connected with a heating unit, and the heating unit includes a heating assembly 3 and a plurality of temperature sensors 8 , the temperature sensors 8 are connected with the controller 6 . A plurality of the temperature sensors 8 are arranged on the inner wall of the kettle body 1, and the plurality of temperature sensors 8 are evenly arranged at equal intervals along the inner wall of the kettle body from top to bottom. The heating assembly 3 surrounds the outside of the kettle body 1 in a spiral shape. A heat transfer medium 2 is provided between the kettle body 1 and the heating assembly 3 , and the heating assembly 3 indirectly heats the kettle body 1 through the heat transfer medium 2 ...
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The invention relates to an online detection device for a drug preparation process, the online detection device comprises a reaction kettle, an injection device, a Raman spectroscopy detection systemand a controller, wherein the injection device injects a reaction raw material into the reaction kettle, the injection device comprises an injection tube, the injection tube is respectively connectedwith a material storage unit and a syringe pump, the material storage unit is used for containing the reaction raw material, the injection pump is connected with the controller, the Raman spectroscopydetection system comprises a laser, a fiber sensor and a Raman spectrometer, the Raman spectrometer is connected to the controller, the fiber sensor comprises a light scattering probe, the light scattering probe includes a probe and a detector facing the probe, the probe is connected with the laser through input fiber, the detector receives laser light from the probe and emits scattered light, the probe collects the scattered light and transmits the scattered light to the Raman spectrometer through the output fiber, the controller receives an output signal of the Raman spectrometer, the detector comprises a planar substrate and a nano-array on the surface of the substrate, and the nano-array comprises a plurality of carbon nanotubes.
Description
technical field [0001] The invention relates to the technical field of drug production process detection, in particular to an on-line detection device for the drug preparation process. Background technique [0002] At present, in the process of drug synthesis, the reactants are usually added manually. There is a certain error in the amount of addition, which may have a great impact on the subsequent reaction. Perform chromatographic analysis, but the chromatographic analysis takes a long time. For the detection of unstable products, the timeliness of detection is very important. If it is left for a long time to detect again, the concentration or structure of the product will change significantly. The accuracy of the test results cannot be guaranteed. As an analytical method, Raman spectroscopy is widely used in the fields of chemistry, biology, and medicine due to its unique advantages such as rich information, simple sample preparation, and small water interference. Howev...
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IPC IPC(8): G01N21/65
CPCG01N21/65
Inventor 郑钢刘耀光于浩
Owner SUZHOU EUROPOD PRECISION INSTR TECH CO LTD