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A kind of temperature-controlled drug delivery microbubble patch and preparation method thereof

A microbubble and drug delivery technology, applied in the field of materials, can solve the problems of short duration of drug effect, short duration of drug effect, prolonged drug effect time, etc., to improve blood circulation and lymph circulation, fast onset of action, and therapeutic effect. Good results

Active Publication Date: 2020-12-01
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method can directly exert the drug effect, but the lasting time is not long, the drug effect takes a short time, and the waste is serious
Through searching, it has not been found that there is a microbubble patch that uses the switch, especially the human body temperature as a switch to prolong the drug effect time.

Method used

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  • A kind of temperature-controlled drug delivery microbubble patch and preparation method thereof
  • A kind of temperature-controlled drug delivery microbubble patch and preparation method thereof
  • A kind of temperature-controlled drug delivery microbubble patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A preparation method of a polyacrylamide gel containing poly(N-isopropylacrylamide) microspheres, comprising the following steps:

[0053] 1) Preparation of poly(N-isopropylacrylamide) microspheres:

[0054] Weigh 0.15g of Span 80 into a 100ml beaker, add 75mL of kerosene, put it into a magnetic stirrer, seal it with a plastic wrap and start stirring. During the stirring process, nitrogen gas is introduced for 10 minutes. After stirring, pour the oil phase into a three-necked flask, add 50 microliters of TMEDA (N,N,N',N'-tetramethylethylenediamine), and seal it. Turn on the mechanical stirring at a speed of 350 r / min, and pass nitrogen gas for 5 minutes while stirring.

[0055] Weigh 5.00 g of N-isopropylacrylamide and 0.50 g of N,N-methylenebisacrylamide into a small beaker, add 20 mL of distilled water, stir to dissolve, seal it, and blow nitrogen for 5 minutes to prepare an aqueous phase.

[0056] In the flask, add the water phase to the oil phase, seal and ventila...

Embodiment 2

[0067] see Figure 6 , Figure 7 as well as Figure 8 , the present invention is based on the temperature-sensitive material obtained in Example 1 to form a temperature-controlled drug delivery microbubble patch based on the polyacrylamide gel containing poly(N-isopropylacrylamide) microspheres. The drug-controlling microbubble patch includes gelatin microvesicle 1, temperature-sensitive sealing film 2, adhesive film 3, and protective layer 4; gelatin microvesicle 1 is in the shape of a hollow bubble; One side of the sealing film 2 is adhesively attached to the gelatin microvesicle 1 and the opening on the gelatin microvesicle 1 is closed; the other side of the temperature-sensitive sealing film 2 is connected with the protective layer 4 through the adhesive film 3; the temperature-sensitive sealing film 2 is directly used Polyacrylamide gels containing poly(N-isopropylacrylamide) microspheres were tiled.

[0068] The temperature-controlled drug delivery microbubble patch a...

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Abstract

The invention relates to a temperature-controlled medication administration microbubble patch and a preparation method. The temperature-controlled medication administration microbubble patch comprisesa gelatin microbubble capsule, a temperature-sensitive sealing film, a sticky film and a protective layer, wherein the gelatin microbubble capsule is in a hollow bubble shape and is provided with anopening; one surface of the temperature-sensitive sealing film is adhered and attached with the gelatin microbubble capsule to seal the opening of the gelatin microbubble capsule; the other surface ofthe temperature-sensitive sealing film is connected with the protective layer through the sticky film; the temperature-sensitive sealing film is prepared by a polyacrylamide gel containing poly(N-isopropylacrylamide) microspheres; the polyacrylamide gel containing the poly(N-isopropylacrylamide) microspheres is used as a temperature switch to control the medicine release in the gelatin micro-bubble capsule, and is sensitive to the temperature, and can be used as a temperature switch. The temperature-controlled medication administration microbubble patch and the preparation method have the advantage that the temperature-controlled medication administration microbubble patch is sensitive to the temperature, can be used as a temperature-sensitive sensor and can effectively extend the medicine effect time.

Description

technical field [0001] The invention belongs to the field of materials, and relates to a temperature-controlled drug delivery microbubble patch and a preparation method thereof, in particular to a temperature-controlled drug delivery microbubble patch comprising polyacrylamide gel containing poly(N-isopropylacrylamide) microspheres. Foam paste and preparation method. Background technique [0002] Administration through the skin is divided into local action on the skin (skin surface administration) and systemic action through skin penetration (transdermal absorption administration, transdermal administration). Transdermal drug delivery is a non-invasive drug delivery route that can maintain the effective drug level in the body, and can realize the controlled release of drugs with expected action time and long-term action time. Diffusion-controlled transdermal systems are devices designed to control the delivery of therapeutic ingredients from drug delivery devices to the ski...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/42A61P21/00A61P19/02A61P29/00A61P19/04A61P15/00
CPCA61K9/0004A61K9/703A61K47/32A61K47/42
Inventor 肖新才宋庭宁洪宗国
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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