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Amitriptyline hydrochloride oral instant film

A technology of amitriptyline hydrochloride and oral fast-dissolving film, applied in the directions of anti-inflammatory agent, non-central analgesic, drug combination, etc., can solve the problem of no amitriptyline hydrochloride oral fast-dissolving film, etc. Water-based and moisturizing effects, good film-forming properties, and absorption-promoting effects

Active Publication Date: 2020-12-08
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the dosage form of domestic amitriptyline hydrochloride is mainly tablets. According to the data published on the website of the State Food and Drug Administration: there are 2 kinds of domestic drugs and 0 imported drugs for amitriptyline hydrochloride raw materials; amitriptyline hydrochloride There are 3 kinds of domestic drugs in Linpian, and 0 imported drugs. At present, there is no relevant report on amitriptyline hydrochloride oral instant film

Method used

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  • Amitriptyline hydrochloride oral instant film
  • Amitriptyline hydrochloride oral instant film
  • Amitriptyline hydrochloride oral instant film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Dissolve 0.12g of HA in 15ml of 60% ethanol, and dissolve with magnetic stirring at 60°C, then add 1.2g of HPMC, and dissolve with magnetic stirring at 60°C.

[0037] The solution was allowed to stand for degassing, and the film was coated on the substrate according to the specification of 15cm×15cm, and then dried in an oven at 60°C for 2 hours.

[0038] Leave the dried film to cool down, remove the film, and cut it into a size of 1.5cm×2cm.

Embodiment 2

[0040] The film was prepared with reference to the method of Example 1, except that the quality of HA was 0.06g.

Embodiment 3

[0042] The film preparation was prepared with reference to the method of Example 1, except that the quality of HA was 0.04 g.

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Abstract

The invention relates to an amitriptyline hydrochloride oral fast dissolving film agent which is prepared from amitriptyline hydrochloride, a film-forming material, a plasticizer, a disintegrant and apermeation enhancing agent; the film-forming material is hydroxypropyl methylcellulose and hyaluronic acid; and the mass ratio of the amitriptyline hydrochloride to the film-forming material to the plasticizer to the disintegrant to the permeation enhancing agent is 1 to (1 to 1.2) to (0.2 to 0.5) to (0.05 to 0.10) to (0.02 to 0.13). The amitriptyline hydrochloride oral fast dissolving film agentprovided by the invention is convenient in administration without water drinking, is fast in effect and is particularly suitable for administration of a child.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a fast-dissolving amitriptyline hydrochloride oral film. Background technique [0002] Due to their physiological and psychological differences, people of different age groups need to consider different physiological and pharmacokinetic characteristics, and their formulation capabilities also vary greatly. Among the various routes of administration, oral administration is the most acceptable to patients. At present, commonly used oral dosage forms mainly include tablets, capsules, granules, and liquid preparations. For children and elderly patients, ordinary tablets, capsules, etc. are prone to problems such as difficulty in swallowing or chewing. Therefore, children Most of the medications are liquid preparations such as syrups and suspensions. However, the transportation, storage and carrying of liquid preparations are inconvenient, and the liquid preparations with ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/135A61K47/10A61K47/36A61K47/38A61P25/24A61P29/00A61P25/00
CPCA61K9/006A61K9/7007A61K31/135A61K47/10A61K47/36A61K47/38
Inventor 崔京浩赵兴娟狄孟华曹青日
Owner SUZHOU UNIV
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