Degradable metal composite plate for cranio-maxillofacial bone restoration and preparation method thereof

A metal composite plate, craniofacial technology, applied in the direction of metal rolling, metal rolling, metal processing equipment, etc., can solve the problems of slow degradation of iron-based metals, difficult to control the degradation time, etc., to achieve excellent biocompatibility The effect of sex and guided defect bone regeneration, simple processing method, and low manufacturing cost

Inactive Publication Date: 2018-07-20
NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the degradation rate of magnesium-based metals in the human body is relatively fast, and surface treatment is usually required to prolong the degradation time, while the degradation rate of zinc-base...

Method used

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  • Degradable metal composite plate for cranio-maxillofacial bone restoration and preparation method thereof

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Effect test

preparation example Construction

[0022] A method for preparing a degradable metal composite plate for repairing craniomaxillofacial bone, which is mainly made by coating the surface of a magnesium-based or iron-based metal plate 1 with a zinc-based metal plate 2 and then stacking and rolling. The processing method is simple, The parameters of the formed metal composite board are easy to control, and the manufacturing cost is low. Specifically include the following steps:

[0023] Step 1: Before rolling, a plurality of grooves or tetrahedral pits are uniformly and densely distributed on the two surfaces of the magnesium-based or iron-based metal plate 1, and two layers of zinc-based metal plates 2 are respectively coated on the surface. The two surfaces of the magnesium-based or iron-based metal plate 1 with grooves or tetrahedron-shaped pits, and then the rolled front-end faces of the zinc-based metal plate 2 and the magnesium-based or iron-based metal plate 1 clad together are welded together; Wherein, the ...

Embodiment 1

[0028] Take a magnesium-zinc-zirconium alloy plate with a length, width, and thickness of 150mm, 100mm, and 3mm respectively, and a zinc-magnesium-copper alloy plate with a thickness of 0.4mm, and press tetrahedral pits with a depth of 0.15mm on both sides of the magnesium-zinc-zirconium alloy plate. Cover the magnesium-zinc-zirconium alloy plate with a cleaned zinc-magnesium-copper alloy plate with a thickness of 0.4mm, and weld the zinc-magnesium-copper alloy plate and the magnesium-zinc-zirconium alloy plate coated on the rolling front end. Heat the clad plate to 250°C, and control the rolling deformation in a single pass at 10% to 30%. After 6 passes of hot stack rolling, the final plate thickness is controlled to be 1.0mm, so that the thickness of the magnesium-zinc-zirconium alloy plate is about 0.8mm, the single-layer zinc-magnesium-copper alloy plate thickness is about 0.1mm, and the thickness ratio of the magnesium-based metal plate and the zinc-based metal plate in th...

Embodiment 2

[0030]Take a magnesium-zinc-calcium alloy plate with a length, width, and thickness of 80mm, 40mm, and 7.5mm respectively, and a pure zinc plate with a thickness of 0.5mm, and press a tetrahedral pit with a depth of 0.2mm on both sides of the magnesium-zinc-zirconium alloy plate. Cover the magnesium-zinc-calcium alloy plate with a cleaned pure zinc plate with a thickness of 0.5mm, and weld the pure zinc plate coated on the front end of the rolling with the magnesium-zinc-calcium alloy plate. Heat the clad plate to 250°C, and control the rolling deformation in a single pass at 10% to 30%. After 5 passes of hot stack rolling, the final plate thickness is controlled to be 3.4mm, so that the thickness of the magnesium-zinc-calcium alloy plate is about 3mm, the thickness of a single-layer pure zinc plate is about 0.2mm, and the thickness ratio of the magnesium-based metal plate and the zinc-based metal plate in the composite plate is 15. The prepared plate can be used for jaw bone ...

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Abstract

The invention provides a degradable metal composite plate for the cranio-maxillofacial bone restoration and a preparation method thereof. The metal composite plate comprises a layer of magnesium-basedor iron-based metal plate and two layers of zinc-based metal plates, wherein the two layers of zinc-based metal plates are respectively compounded onto the two surfaces of the magnesium-based or iron-based metal plate to form a zinc-magnesium-zinc three-layer metal composite plate or a zinc-iron-zinc three-layer metal composite plate. The degradable metal composite plate for the cranio-maxillofacial bone restoration of the structure can solve the problems of poor biocompatibility, undegradability and requirement of secondary operation for taking out of a cranio-maxillofacial bone restorationmaterial in clinics. Through controlling the thickness ratio of the magnesium-based or iron-based metal plate and the zinc-based metal plate, the regulation on the metal composite degradation time canbe achieved, so that the degradation speed can better correspond to the human body restoration speed; the human body restoration speed is accelerated. By the coating lamination rolling preparation method, the zinc-based metal plate is compounded onto the surface of the magnesium-based or iron-based metal plate to form the degradable cranio-maxillofacial bone restoration material; the process treatment method is simple; the control is easy; the manufacturing cost is low.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a degradable metal composite plate for craniofacial bone repair and a preparation method thereof. Background technique [0002] At present, craniofacial repair materials used clinically are mainly composed of metal materials or polymer materials. Most of the metal materials used are titanium-based non-degradable metals, and the polymer craniofacial repair materials are generally polyether ether ketone or polylactic acid. At present, these two types of materials can basically meet the clinical needs, but there are also certain limitations and potential problems. For example, for craniofacial repair of minors, because their bones are not yet fully mature, using non-degradable materials will hinder the development of later bones; using degradable polylactic acid as craniofacial repair materials, due to its degradation process Lactic acid monomers will be r...

Claims

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Application Information

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IPC IPC(8): B32B15/01B32B15/18B32B7/08A61L27/58A61L27/40B21B47/00B21B1/38
CPCA61L27/042A61L27/047A61L27/58A61L2430/02B21B1/38B21B47/00B21B2001/386B32B7/08B32B15/01B32B15/013B32B2250/40B32B2307/7145B32B2307/716B32B2535/00
Inventor 王昌于振涛余森麻西群赵曦程军刘汉源
Owner NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
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