Degradable metal composite plate for cranio-maxillofacial bone restoration and preparation method thereof

Abstract

The invention provides a degradable metal composite plate for the cranio-maxillofacial bone restoration and a preparation method thereof. The metal composite plate comprises a layer of magnesium-basedor iron-based metal plate and two layers of zinc-based metal plates, wherein the two layers of zinc-based metal plates are respectively compounded onto the two surfaces of the magnesium-based or iron-based metal plate to form a zinc-magnesium-zinc three-layer metal composite plate or a zinc-iron-zinc three-layer metal composite plate. The degradable metal composite plate for the cranio-maxillofacial bone restoration of the structure can solve the problems of poor biocompatibility, undegradability and requirement of secondary operation for taking out of a cranio-maxillofacial bone restorationmaterial in clinics. Through controlling the thickness ratio of the magnesium-based or iron-based metal plate and the zinc-based metal plate, the regulation on the metal composite degradation time canbe achieved, so that the degradation speed can better correspond to the human body restoration speed; the human body restoration speed is accelerated. By the coating lamination rolling preparation method, the zinc-based metal plate is compounded onto the surface of the magnesium-based or iron-based metal plate to form the degradable cranio-maxillofacial bone restoration material; the process treatment method is simple; the control is easy; the manufacturing cost is low.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a degradable metal composite plate for craniofacial bone repair and a preparation method thereof. Background technique [0002] At present, craniofacial repair materials used clinically are mainly composed of metal materials or polymer materials. Most of the metal materials used are titanium-based non-degradable metals, and the polymer craniofacial repair materials are generally polyether ether ketone or polylactic acid. At present, these two types of materials can basically meet the clinical needs, but there are also certain limitations and potential problems. For example, for craniofacial repair of minors, because their bones are not yet fully mature, using non-degradable materials will hinder the development of later bones; using degradable polylactic acid as craniofacial repair materials, due to its degradation process Lactic acid monomers will be r...

AI Technical Summary

Problems solved by technology

However, the degradation rate of magnesium-based metals in the human body is relatively fast, and surface treatment is usually required to prolong the degradation time, while the degradation rate of zinc-based metals in the human body is relatively moderate, and the degradation rate of iron-based metals is relatively slow

It is difficult to control the degradation time of the three metals as a single degradable material

Images