Method, device for formic acid solvent recycling in metronidazole production and application thereof

A solvent recycling, metronidazole technology, applied in the direction of organic chemistry, to achieve the effect of increasing the contact area, efficient absorption, and preventing pollution

Active Publication Date: 2018-07-27
HUANGGANG NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But recovered methyl formate can only be sold at a low price

Method used

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  • Method, device for formic acid solvent recycling in metronidazole production and application thereof

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Embodiment Construction

[0045] Embodiments of the present invention will now be described in detail in conjunction with the accompanying drawings.

[0046] A device for the recycling of formic acid solvent in the production of metronidazole, is characterized in that, comprising:

[0047] Sulfur trioxide steel cylinder 10 and weighing device 90, sulfur trioxide steel cylinder 10 is placed on the weighing device 90, on which opening and closing valve 11 and pressure reducing valve 12 are provided;

[0048] Liquid seal tank 20, there is lye in it;

[0049] Negative pressure tank 30, its upper part is provided with tank gas inlet, tank gas outlet, tank residual gas outlet and tank venting port, tank gas inlet is connected with sulfur trioxide cylinder 10 pipelines, tank residual gas outlet is connected with liquid seal tank 20 pipelines , a vent valve 31 is provided at the vent port of the tank; a tank gas-liquid mixing inlet, a tank return port and a tank liquid discharge port are provided at the botto...

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Abstract

The invention provides a method, a device for formic acid solvent recycling in metronidazole production and an application thereof. In a metronidazole synthesis process, the recycling of formic acid is realized, and the production cost is saved. In a metronidazole production process, sulfur trioxide consumes water to generate sulfuric acid, the water in formic acid solution is gradually consumed,and the sulfuric acid needed for the metronidazole synthesis is generated. The reduction of the water is beneficial to a follow-up synthetic process of the metronidazole. The device is capable of introducing the sulfur trioxide into an injector by using the injector and mixing with solution, and improving the mixing efficiency. Because of the action of the injector, the sulfuric acid concentrationof liquid at the bottom of a negative pressure tank is greater than the sulfuric acid concentration of the liquid at the top, the liquid at the top is replaced in a storage tank for recycling by using a hose and a floating head, and pumped back by a power pump, thereby the sulfuric acid concentration of the liquid mixed with the sulfur trioxide is the lowest, and beneficial to the high-efficientmixing. Alkaline liquor in a liquid seal tank is used for absorbing an acid gas, and the pollution is prevented.

Description

technical field [0001] The invention belongs to the field of organic synthesis, and in particular relates to a method, device and application for recycling formic acid solvent in the production of metronidazole. Background technique [0002] Mixed acids are important organic synthesis solvents. For example: the mixed acid of sulfuric acid and formic acid is the synthesis solvent of metronidazole, and the mixed acid of sulfuric acid and acetic acid is the synthesis solvent of fipronil. Take metronidazole as an example: metronidazole is white or yellowish crystal or crystalline powder, which is used to treat intestinal and extraintestinal amoebiasis (such as amoebic liver abscess, pleural amoebiasis, etc.). It can also be used to treat vaginal trichomoniasis, cylindrosis, skin leishmaniasis, and guinea worm infection. At present, it is also widely used in the treatment of anaerobic infection, and is regarded as the drug of choice for anti-anaerobic bacteria by the World Heal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/94
CPCC07D233/94
Inventor 曾舟华曾昆胡全胜黄林勇杨水彬倪勇
Owner HUANGGANG NORMAL UNIV
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