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Application of forsythiaside A to preparation of weight-reducing medicine

A technology of forsythiaside and medicine is applied in the application field of forsythiaside A in the preparation of weight loss medicine, and can solve problems such as large side effects and the like

Inactive Publication Date: 2018-08-03
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug is a pancrelipase inhibitor, but it has serious side effects, especially liver damage

Method used

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  • Application of forsythiaside A to preparation of weight-reducing medicine
  • Application of forsythiaside A to preparation of weight-reducing medicine
  • Application of forsythiaside A to preparation of weight-reducing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Detection of enzyme inhibitory activity of unprocessed forsythia leaf water extract

[0030] Pick fresh forsythia leaves, wash to remove leaf surface attachments, dry, pulverize, accurately weigh 100g of powder, the ratio of solid to liquid is 1:10, reflux for 2h, the water extract is concentrated and dried, and tested for inhibition of pancreatic lipase activity, 1500μg / mL inhibition rate can reach 26.5% ( figure 1 ).

Embodiment 2

[0031] Example 2: Detection of enzyme inhibitory activity of unprocessed forsythia leaf absolute ethanol extract

[0032] Pick fresh forsythia leaves, wash to remove leaf surface attachments, dry, pulverize, accurately weigh 100g of powder, the ratio of solid to liquid is 1:10, reflux for 2 hours, concentrate and dry the absolute ethanol extract, and detect the activity of pancreatic lipase inhibition. 1500μg / mL inhibition rate can reach 33.8% ( figure 1 ).

Embodiment 3

[0033] Example 3: Detection of enzyme inhibitory activity of water extract of boiled forsythia leaf processed product

[0034] Pick fresh forsythia leaves, wash to remove leaf surface attachments, boil in water for 5-7 minutes, dry, crush, accurately weigh 100g of powder, the ratio of solid to liquid is 1:10, reflux extraction for 2 hours, the water extract is concentrated and dried, and the enzyme activity is inhibited Detection and animal experiments confirmed that the water extract of the processed forsythia leaf was detected by inhibiting pancreatic lipase activity, and the inhibition rate of 1500 μg / mL could reach 33.2% ( figure 1 ).

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PUM

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Abstract

The invention discloses application of a mixture or a single component of forsythiaside A and isomers thereof to preparation of a weight-reducing medicine. Through separation and identification of aqueous extracts or different-ethanol concentration ethanol extracts of forsythia suspensa leaves and detection of pancreatic lipase inhibiting activity, results show that ursolic acid, oleanolic acid, rutin, hesperidin, forsythiaside A and the isomers thereof, chlorogenic acid, caffeic acid, arctigenin and kaempferol-3-O-rutinoside as main components have the in-vitro pancreatic lipase inhibiting effect, wherein the forsythiaside A has the pancreatic lipase inhibiting activity IC50 of 1346[mu]g / mL. Therefore, the mixture or the single component of the forsythiaside A and the isomers thereof canbe applied to preparation of the weight-reducing medicine, a weight-reducing health-care product and weight-reducing food.

Description

technical field [0001] The present invention relates to a new application of the plant or its extract, in particular to the application of forsythia leaf or its components in the preparation of weight-loss products, that is, the application in the preparation of weight-loss medicine, weight-loss health care product and weight-loss food. Background technique [0002] The World Health Organization has clearly identified obesity as the largest chronic disease in the world and a global epidemic [Report ofa WHO consultation.2000,894:i-xii,1-253]. More than 1 billion adults and 10% of children in the world are overweight and obese [Haslam DW, et al. Lancet. 2005, 366(9492): 1197-209]. The adult overweight rate in my country is 22.8%, and the obesity rate is 7.1%. The estimated numbers are 200 million and 60 million respectively [Wang Longde editor-in-chief. People's Health Publishing House, 2005]. [0003] Excessive obesity can cause 57% of non-insulin-dependent (type II) diabete...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P3/04A23L33/105A61K36/634
Inventor 陈廷贵李飞鹤栗亚云张立伟
Owner SHANXI UNIV