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A kind of preparation method of biocompatible water-soluble polyaniline

A biocompatible and water-soluble technology, applied in the field of preparation of water-soluble polyaniline, can solve the problems of limited ratio of polyaniline, poor biocompatibility of polyaniline, large molecular weight of polyethylene glycol, etc.

Active Publication Date: 2022-01-07
山东赫达集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent has the following deficiencies: (1) polyaniline with low molecular weight has strong carcinogenicity, and its preparation and operation have huge potential safety hazards to the human body; The ratio is limited, so that the water solubility is poor; (3) the preparation process is complicated, and the introduction of polyethylene glycol, the steric effect of macromolecular groups reduces the electrical conductivity of polyaniline; (4) the polyaniline biophase prepared by this method Poor capacity, not environmentally friendly to the human body, can not be used in areas that are in contact with the human body

Method used

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Experimental program
Comparison scheme
Effect test

preparation example Construction

[0017] The invention discloses a preparation method of biocompatible water-soluble polyaniline, which comprises the following steps:

[0018] Step 1: Add aniline with water-soluble groups in the ortho-meta position, deionized water, and bioprotic acid into the reactor, stir continuously, and then add the aqueous solution of biological oxidant to the reaction system dropwise, and initiate polymerization at 0-50°C 0.5~24h;

[0019] Step 2: adding ethanol to the system, polyaniline precipitates out, filters, washes with ethanol until the filtrate is colorless, and obtains biocompatible water-soluble polyaniline;

[0020] Step 3: drying the biocompatible water-soluble polyaniline at 60-100° C., and pulverizing to obtain the biocompatible water-soluble polyaniline powder.

[0021] The aniline with a water-soluble group in the ortho-meta position is at least one of polyaniline with a hydroxyl group in the ortho-meta position and polyaniline with a carboxyl group in the ortho-meta p...

Embodiment 1

[0030] Step 1: Add aniline, deionized water, and citric acid with ortho-carboxyl groups into the reactor, stir continuously, then add 0.8mol / L catalase aqueous solution dropwise into the reaction system, and initiate polymerization at 0°C for 24h Wherein, the mass ratio of aniline and deionized water is 0.3:1, the mol ratio of citric acid and aniline is 5:1, and the mol ratio of catalase and aniline is 0.8:1.

[0031] Step 2: adding ethanol to the system, polyaniline precipitates out, filters, washes with ethanol until the filtrate is colorless, and obtains biocompatible water-soluble polyaniline.

[0032] Step 3: drying the biocompatible water-soluble polyaniline at 60° C., and pulverizing to obtain the biocompatible water-soluble polyaniline powder.

Embodiment 2

[0034] Step 1: Add aniline, deionized water, and lactic acid with ortho-hydroxyl groups into the reactor, stir continuously, then add 1.5mol / L peroxidase aqueous solution dropwise into the reaction system, and initiate polymerization at 50°C for 0.5h ;, the mass ratio of aniline to deionized water was 0.5:1, the molar ratio of lactic acid to aniline was 10:1, and the molar ratio of peroxidase to aniline was 1.2:1.

[0035] Step 2: adding ethanol to the system, polyaniline precipitates out, filters, washes with ethanol until the filtrate is colorless, and obtains biocompatible water-soluble polyaniline.

[0036] Step 3: drying the biocompatible water-soluble polyaniline at 100° C., and pulverizing to obtain biocompatible water-soluble polyaniline powder.

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Abstract

The invention discloses a preparation method of water-soluble polyaniline with biocompatibility. The aniline with a water-soluble group at the first ortho-meta position, deionized water and biomass tic acid are added into a reactor, and the mixture is continuously stirred evenly, and then The biological oxidant aqueous solution is added dropwise to the reaction system, and the polymerization is initiated at 0 to 50 ° C for 0.5 to 24 hours; then ethanol is added to the system, the polyaniline is precipitated, filtered, and washed with ethanol until the filtrate is colorless, and a biocompatible solution is obtained. Finally, the water-soluble polyaniline with biocompatibility is dried at 60-100 DEG C, and pulverized to obtain the water-soluble polyaniline powder with biocompatibility. The polyaniline obtained by the preparation method has the advantages of excellent water solubility, good biocompatibility, good electrical conductivity, good anti-corrosion performance and simple process, and can be applied in the fields of optoelectronics, light-emitting diodes, sensors, electromagnetic shielding and metal anti-corrosion, etc. The advantages are even more significant in the fields of sensors, artificial muscles, and coatings that are in contact with the human body.

Description

technical field [0001] The invention relates to the field of preparation of conductive polymers, in particular to a preparation method of biocompatible water-soluble polyaniline. Background technique [0002] Conductive polyaniline has the advantages of cheap raw materials, simple synthesis process, good conductivity, good environmental stability and special doping mechanism, etc. It is considered to be one of the most promising conductive polymers in optoelectronics, light-emitting diodes, It has broad application prospects in the fields of sensors, electromagnetic shielding and metal anticorrosion. However, the strong rigidity and strong interchain interaction of conductive polyaniline make it insoluble and infusible, difficult to form and process, and poor comprehensive mechanical properties, which seriously limit its practical application. Therefore, improving the solubility of polyaniline has become a topic of great concern to researchers at home and abroad. Chinese p...

Claims

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Application Information

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IPC IPC(8): C08G73/02
CPCC08G73/0266
Inventor 王仕伟
Owner 山东赫达集团股份有限公司