Unlock instant, AI-driven research and patent intelligence for your innovation.

A drug microcapsule preparation for treating non-small cell lung cancer and its preparation method

A technology of microcapsules and preparations, applied in the field of icotinib hydrochloride microcapsule preparations and its preparation, can solve the problems of low drug loading, poor encapsulation efficiency, and restrictions on widespread use, and achieve large drug loading and encapsulation Good rate, avoid the effect of peak and valley phenomenon

Inactive Publication Date: 2020-03-10
JILIN UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Microcapsules are a new dosage form developed in the past 30 years. At present, there are problems such as low drug loading and poor encapsulation efficiency, which limit the widespread use of this method.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A drug microcapsule preparation for treating non-small cell lung cancer and its preparation method
  • A drug microcapsule preparation for treating non-small cell lung cancer and its preparation method
  • A drug microcapsule preparation for treating non-small cell lung cancer and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: the preparation of Icotinib hydrochloride tablet of the present invention

[0041]

[0042] Preparation Process:

[0043] ① Mix and pulverize icotinib hydrochloride and chitosan to 100 meshes, place in a fluidized bed, pass in hot air to suspend and fluidize it, the temperature of the hot air is 60-65°C;

[0044] ② Add hydroxypropyl methylcellulose acetate succinate to acetone to prepare a solution of hydroxypropyl methylcellulose acetate succinate in acetone with a mass percentage of 1-5%.

[0045]③Atomize the hydroxypropylmethylcellulose acetate succinate solution of the capsule material through the nozzle of the fluidized bed and continuously add it to the fluidized bed. The atomization pressure is 0.2-0.4Mpa; After the completion, continue air drying, remove the solvent, stop heating, cool and discharge, and obtain icotinib hydrochloride microcapsules;

[0046] ④ Mix the icotinib hydrochloride microcapsules with the prescribed amount of low-substi...

Embodiment 2

[0047] Embodiment 2: Preparation of Icotinib Hydrochloride Microcapsule Tablets of the present invention

[0048]

[0049] Preparation Process:

[0050] ① Mix and pulverize icotinib hydrochloride and chitosan to 100 meshes, place in a fluidized bed, pass in hot air to suspend and fluidize it, the temperature of the hot air is 60-65°C;

[0051] ② Add hydroxypropyl methylcellulose acetate succinate to acetone to prepare a solution of hydroxypropyl methylcellulose acetate succinate in acetone with a mass percentage of 1-5%.

[0052] ③Atomize the hydroxypropylmethylcellulose acetate succinate solution of the capsule material through the nozzle of the fluidized bed and continuously add it to the fluidized bed. The atomization pressure is 0.2-0.4Mpa; After the completion, continue air drying, remove the solvent, stop heating, cool and discharge, and obtain icotinib hydrochloride microcapsules;

[0053] ④ Mix the icotinib hydrochloride microcapsules with the prescribed amount of...

Embodiment 3

[0054] Embodiment 3: Preparation of Icotinib Hydrochloride Microcapsule Tablets of the present invention

[0055]

[0056] Preparation Process:

[0057] ① Mix and pulverize icotinib hydrochloride and chitosan to 100 meshes, place in a fluidized bed, pass in hot air to suspend and fluidize it, the temperature of the hot air is 60-65°C;

[0058] ② Add hydroxypropyl methylcellulose acetate succinate to acetone to prepare a solution of hydroxypropyl methylcellulose acetate succinate in acetone with a mass percentage of 1-5%.

[0059] ③Atomize the hydroxypropylmethylcellulose acetate succinate solution of the capsule material through the nozzle of the fluidized bed and continuously add it to the fluidized bed. The atomization pressure is 0.2-0.4Mpa; After the completion, continue air drying, remove the solvent, stop heating, cool and discharge, and obtain icotinib hydrochloride microcapsules;

[0060] ④ Mix the icotinib hydrochloride microcapsules with the prescribed amount of...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of pharmaceutical preparations, relates to a drug micro-capsule preparation for treating non-small cell lung cancer, and particularly to an icotinib micro-capsule preparation and a preparation method thereof. According to the icotinib micro-capsule preparation and the preparation method thereof, a main drug icotinib and an excipient chitosan are taken as core materials, and a capsule wall material hydroxypropyl methyl cellulose acetate succinate is added to prepare an icotinib micro-capsule, then the micro-capsule is uniformly mixed with other auxiliary materials, so as to obtain the icotinib micro-capsule preparation. The micro-capsule preparation prepared by the invention is high in drug loading capacity and good in encapsulation efficiency; the stability of the icotinib is remarkably improved, the untoward effect of the icotinib is reduced, so that drugs can be stably released in the human body, the effect of the icotinib can be better played, and the icotinib micro-capsule preparation is suitable for industrialized mass production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a drug microcapsule preparation for treating non-small cell lung cancer, in particular to an icotinib hydrochloride microcapsule preparation and a preparation method thereof. [0002] technical background [0003] Lung cancer is one of the most common malignant tumors in the world, and it has become the first cause of death from malignant tumors in urban population in my country. Non-small cell lung cancer includes squamous cell carcinoma (squamous cell carcinoma), adenocarcinoma, and large cell carcinoma. Compared with small cell carcinoma, its cancer cells grow and divide more slowly, and spread and metastasize relatively later. Non-small cell lung cancer accounts for about 80% of all lung cancers, and about 75% of the patients are in the advanced stage when they are discovered, and the 5-year survival rate is very low. [0004] Molecular targeted therapy of t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/519A61K47/36A61K47/38A61P11/00A61P35/00
CPCA61K9/5042A61K9/5089A61K31/519A61K47/36A61P11/00A61P35/00
Inventor 于杉杨景慧张敏包宝金
Owner JILIN UNIV