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Application of Crocetin in Prevention and Treatment of Thoracic Aortic Dissection/Aortic Aneurysm

A technology of crocin and thoracic aorta, applied in the field of medicine and biology, can solve problems such as reducing the elasticity of the aorta

Active Publication Date: 2020-06-05
BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned drugs also have many adverse reactions and side effects in clinical practice. For example, β-receptor blockers may reduce aortic elasticity, and there are potential side effects in long-term treatment for young patients. Liver and kidney toxicity of statins , the incompatibility of β-receptor blockers and certain drugs, etc.

Method used

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  • Application of Crocetin in Prevention and Treatment of Thoracic Aortic Dissection/Aortic Aneurysm
  • Application of Crocetin in Prevention and Treatment of Thoracic Aortic Dissection/Aortic Aneurysm
  • Application of Crocetin in Prevention and Treatment of Thoracic Aortic Dissection/Aortic Aneurysm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, the construction of thoracic aortic dissection / aortic aneurysm mouse model (mouse TAD model)

[0023] Construction and evaluation of TAD model in BAPN water-fed mice

[0024] 3-week-old C57BL / 6 background male mice were given normal diet,

[0025] BAPN water-fed group (n=16): BAPN was dissolved in drinking water at a dose of 1 g / kg / day.

[0026] On the 14th day of feeding BAPN, 5 mice were randomly selected for thoracic aortic ultrasound to determine whether there was widening / dissection of the thoracic aorta. After repeated experiments, some mice had formed aortic dissection / aortic aneurysm at 14 days, and began to die one after another. The evaluation scheme for the effect of model-induced dissection / aneurysm is as follows:

[0027] 1. Carry out HE or elastic fiber staining to the mouse aorta after death (specific method sees embodiment 2), measure whether vessel diameter thickens (dissection); Or observe whether the disorder of elastic plate occurs o...

Embodiment 2

[0030] Embodiment 2, give the preventive effect of saffron to aortic dissection / aortic aneurysm

[0031] Crocin is ordered from Zhongnong Boxin (Beijing) Technology Co., Ltd., the article number is BP0406, and the specific name is Crocin I (Crocin I)

[0032] The TAD mouse model was constructed using the BAPN water feeding method as described in Example 1.

[0033] The mice induced with TAD were randomly divided into two groups,

[0034] One group is the saffron prevention group: from the first day of feeding BAPN water, intraperitoneally inject saffron at a dose of 50mg / kg, once every two days;

[0035] The other group is the control group: with the same frequency as the crocin treatment group, the same volume of normal saline is given by intraperitoneal injection.

[0036] Four weeks later, mice in both groups were given angiotensin II (AII) infusion for 24 hours.

[0037] Observation indicators after administration include:

[0038] 1. Body weight: the two groups of mic...

Embodiment 3

[0091] Embodiment 3, give the therapeutic effect of crocin to aortic dissection / aortic aneurysm

[0092] The TAD mouse model was constructed using the BAPN water feeding method as described in Example 1.

[0093] The mice induced with TAD were randomly divided into two groups,

[0094] One group is the saffron treatment group: from the 14th day of feeding water containing BAPN, intraperitoneal injection of saffron at a dose of 80mg / kg, once every two days;

[0095] The other group is the control group: with the same frequency as the crocin treatment group, the same volume of normal saline is given by intraperitoneal injection.

[0096] Four weeks later, mice in both groups were given angiotensin II (AII) infusion for 24 hours.

[0097] Observation indicators after administration include:

[0098] 1. Body weight: the two groups of mice were weighed every day. To see if the drug affects weight versus growth.

[0099] 2. BAPN intake: roughly observe the drinking water of the...

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Abstract

The invention relates to application of crocin to preparation of drugs for preventing and / or treating thoracic aorta dissection / aortic aneurysm. The drugs include drugs fed through the gastrointestinal tract, drugs fed through intravenous injection and drugs fed through a subcutaneous embedding mode, and are preferably drugs fed through the subcutaneous embedding mode.

Description

technical field [0001] The invention belongs to the field of medicine and biology, and in particular relates to the application of crocin in the prevention and treatment of thoracic aortic dissection / aortic aneurysm. Background technique [0002] Aortic aneurysm and aortic dissection are the most serious complications of thoracic aortic disease, the most important feature of which is the tendency to rupture, and the fatality rate of TAD rupture can reach 90%. With the continuous improvement of imaging diagnostic technology, the incidence rate and the number of patients detected by detection are increasing year by year. In the treatment plan for aortic aneurysm and aortic dissection, endovascular repair and artificial stent-type vascular graft are the main treatment methods, but Surgical trauma, and serious complications such as paraplegia and mortality rates as high as 17% and 26%. [0003] In addition to surgical treatment, common treatments for aortic aneurysm and aortic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/194A61P35/00
CPCA61K31/194A61P35/00
Inventor 杜杰李玉琳张言真子
Owner BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES
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