47 results about "Aneurysm dissecting" patented technology

This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their synthetic precursors, R-isomers, and non-hydroxylated and / or non-chiral propanamides, and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their synthetic precursors, R-isomers, and non-hydroxylated and / or non-chiral propanamides, and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

A stent graft includes a tubular aortic component that defines a lumen and a fenestration with a pocket at the fenestration. At least one proximal tunnel graft extends proximally within the lumen from the proximal opening of the pocket and is secured at a proximal end to the tubular component, and at least one distal tunnel graft extends distally within the lumen from the distal opening of the pocket and is secured at a distal end to the tubular aortic component. The stent graft can further include at least one branch stent graft, each of which extends through the fenestration and within at least one of the proximal tunnel graft or the distal tunnel graft. The stent graft can be implanted in a patient to thereby treat an aneurysm, such as a suprarenal or thoracoabdominal aortic aneurysm.

The present invention relates to methods for producing a non human animal model for aortic aneurysm which could provide insight into the diagnosis and treatment of disease. Furthermore, the present invention relates to methods and compositions for the treatment or the prevention of aneurysm in a subject in need thereof.

The invention relates to application of crocin to preparation of drugs for preventing and / or treating thoracic aorta dissection / aortic aneurysm. The drugs include drugs fed through the gastrointestinal tract, drugs fed through intravenous injection and drugs fed through a subcutaneous embedding mode, and are preferably drugs fed through the subcutaneous embedding mode.

The invention belongs to image analysis, and in particular relates to an aneurysm image analysis system, method and device based on dual-flow boundary perception, aiming to solve the problem that the existing image analysis technology cannot accurately analyze the image of aneurysm based on the developed image. The present invention includes: acquiring a DSA image of a region containing an aortic aneurysm as an image to be detected, based on the image to be detected, generating an aortic aneurysm boundary feature image and an aortic aneurysm image mask through a trained two-stream boundary perception network, based on The aortic aneurysm image mask and the aortic aneurysm boundary feature are combined with the DSA image to obtain morphological information of the aortic aneurysm image. The invention improves the accuracy of aneurysm images and solves the problem of blurred boundaries of aneurysm images in the prior art by inputting the extracted features into a dual-stream boundary perception network, simultaneously extracting boundary features and mask images and merging them. Accurate aneurysm morphology analysis.

A class of oral GSNOR inhibitors and pharmaceutical applications thereof, the invention has good oral bioavailability and longer half-life. In vitro experiments, the compound of the present invention can improve the reduction of migration ability and tube-forming ability of human umbilical vein endothelial cells caused by high glucose, and the increase of permeability; Neogenesis and blood flow recovery suggest that the compound of the present invention can be used for treating diseases related to diabetic vascular complications. The compound of the present invention can improve the smooth muscle cell phenotype conversion caused by angiotensin II, and the compound of the present invention can obviously improve the incidence and mortality of aortic aneurysm / dissection, suggesting that the compound of the present invention can be used for the treatment of diseases related to aortic aneurysm / dissection . The compound of the present invention can effectively inhibit the activity of GSNOR, suggesting that the compound of the present invention can be used for treating diseases related to asthma and cystic fibrosis.