Combination preparation of fucoidan and its application

A fucoidan and preparation technology, applied in the field of biomedicine

Active Publication Date: 2020-10-27
山东科桥生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on fucoidan targeting ultrafine particles

Method used

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  • Combination preparation of fucoidan and its application
  • Combination preparation of fucoidan and its application
  • Combination preparation of fucoidan and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The fucoidan combination preparation is composed of the following components in parts by weight: 80 parts of fucoidan, 10 parts of magnolol, 5 parts of Atractylodes macrocephala oil, and 5 parts of chlorogenic acid.

Embodiment 2

[0045] The fucoidan combination preparation consists of the following components in parts by weight: 70 parts of fucoidan, 10 parts of magnolol, 15 parts of Atractylodes macrocephala oil, and 5 parts of chlorogenic acid.

Embodiment 3

[0047] The fucoidan combination preparation is composed of the following components in parts by weight: 50 parts of fucoidan, 20 parts of magnolol, 20 parts of Atractylodes macrocephala oil, and 10 parts of chlorogenic acid.

[0048] The inventor has demonstrated through many experiments that the fucoidan combination preparation provided by the present invention can significantly increase the number of macrophages, promote the phagocytosis of macrophages, and promote the movement of macrophages to the intestinal tract, through small intestinal epithelial cells The ability to excrete fine particles through the intestinal tract to excrete them from the body. Due to limited space, in order to further illustrate the beneficial effects of the present invention, only the optimal embodiment 3 is taken as an example to construct the following relevant comparative examples.

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Abstract

The invention discloses a fucoidin-containing composite preparation and application thereof, and belongs to the field of health care products. The fucoidin composite preparation consists of the following components in parts by weight: 9-80 parts of fucoidin, 1-30 parts of magnolol, 1-30 parts of atractylodes macrocephala koidz oil and 1-20 parts of chlorogenic acid. A zebrafish macrophages PM 2.5phagocytosis is used as a research object, through the research, it discovers that the fucoidin-containing composite preparation can remarkably increase the number of macrophages, the phagocytic ability of the macrophages is promoted, movement of the macrophages to intestinal tracts is promoted, intestinal epithelial cells discharge fine particulate matters, thus, the fine particulate matters aredischarged out of the body through the intestinal tracts, and thus, the purpose of reducing ultra-micro particulate matters in the body is achieved.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a fucoidan combined preparation and its application. Background technique [0002] Fine particulate matter, also known as fine particles, PM2.5, refers to the diameter of the ambient air is less than or equal to 2.5 microns (μm), it can be suspended in the air for a long time, the higher the concentration in the air, the more air pollution serious. Although PM2.5 is only a small component of the earth's atmospheric composition, it has an important impact on air quality and visibility. Compared with coarser atmospheric particles, PM2.5 has small particle size, large area, strong activity, and is easy to carry toxic and harmful substances (such as heavy metals, microorganisms, etc.), and has a long residence time in the atmosphere and a long transportation distance. Therefore, it has a greater impact on human health and atmospheric environmental quality. [0003] In terms of the harm ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/284A61P11/00A61P39/02A61K31/05A61K31/216A61K31/715
CPCA61K31/05A61K31/216A61K31/715A61K36/284A61P11/00A61P39/02A61K2300/00
Inventor 陈锡强王荣春刘可春韩利文王莹张云侯海荣王雪
Owner 山东科桥生物技术有限公司
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