Method and reagent for improving homing and implantation rate of hematopoietic stem cells

A technology of hematopoietic stem cell and implantation rate, applied in the field of hematopoietic stem cell transplantation and biomedicine
CN108404112BActive Publication Date: 2020-05-12BEIJING DAXI BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING DAXI BIOTECHNOLOGY CO LTD
Publication Date
2020-05-12

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Abstract

The invention relates to a method of improving the homing and engraftment rate of hematopoietic stem cells and a reagent of the method. By taking small molecule peptides as a main component to performpretreatment on the hematopoietic stem cells, the method provided by the invention improves the homing and engraftment rate of the hematopoietic stem cells in vivo, shortens the time required for reconstruction of a hematopoietic system, improves the success rate of hematopoietic stem cell transplantation and makes up for the status quo of insufficient sources of the hematopoietic stem cells. Inaddition, low-dose intravenous infusion of the small molecule peptides does not have bad influence on the safety of a human body. Thus, the invention actually provides application of the small molecule peptides in preparing a drug for treating diseases of a blood system.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, in particular to the field of hematopoietic stem cell transplantation, and more specifically relates to a method for improving the homing and implantation rate of hematopoietic stem cells and a reagent thereof. Background technique

[0002] Hematopoietic stem cells refer to a class of cells with self-renewal and multidirectional differentiation capabilities. Its basic feature is self-renewal ability, that is, after a cell cycle activity, it can produce two hematopoietic stem cells with the same properties as before division, and it also has multi-directional differentiation ability, that is, under certain environmental conditions, hematopoietic stem cells have The ability to differentiate into various blood cell lines.

[0003] Hematopoietic stem cell transplantation is currently widely used in the treatment of malignant blood diseases, non-malignant refractory blood diseases, genetic diseas...

Claims

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