Preparation and application of long wavelength colorimetric fluorescent probe capable of rapidly and high-selectively analyzing thiophenol

A dinitrobromobenzene and compound technology, applied in the field of long-wavelength colorimetric fluorescent probes, can solve problems such as short excitation and emission wavelengths, insufficient response speed, and insufficient selectivity, and achieve fast reaction speed and stability Good, easy to synthesize effects

Inactive Publication Date: 2018-09-04
UNIV OF JINAN
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently reported colorimetric fluorescent probes still have some problems, including insufficient selectivity, insufficient response speed, short excitation and emission wavelengths, complex synthesis, etc.

Method used

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  • Preparation and application of long wavelength colorimetric fluorescent probe capable of rapidly and high-selectively analyzing thiophenol
  • Preparation and application of long wavelength colorimetric fluorescent probe capable of rapidly and high-selectively analyzing thiophenol
  • Preparation and application of long wavelength colorimetric fluorescent probe capable of rapidly and high-selectively analyzing thiophenol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]

[0031] (Scheme 1) Dissolve 741mg (3mmol) of 2,4-dinitrobromobenzene in 8mL of DMF solution, then add 453mg (1mmol) of FR dye and 650mg (2mmol) of cesium carbonate and stir at room temperature for 10h, then add water to precipitate the solid to obtain crude product. If a purer product is to be obtained, the crude product can be subjected to thin-layer chromatography with pure dichloromethane system to obtain a pure product. 574 mg of pure orange product was obtained with a yield of 82%.

[0032] (Scheme 2) Dissolve 988mg (4mmol) of 2,4-dinitrobromobenzene in 8mL of DMF solution, then add 453mg (1mmol) of FR dye and 650mg (2mmol) of cesium carbonate and stir at room temperature for 10h, then add water to precipitate the solid to obtain crude product. If a purer product is to be obtained, the crude product can be subjected to thin-layer chromatography with pure dichloromethane system to obtain a pure product. Obtained 490mg of orange pure product, the yield was 70%...

Embodiment 2

[0037] figure 1 It is the fluorescence spectrum of the probe (5μM) before and after adding thiophenol (50μM). We can see that the fluorescence change is very obvious through the illustration.

Embodiment 3

[0039] Figure 2a is the effect of different concentrations of thiophenol (0-150μM) on the fluorescence intensity of the probe (5μM).

[0040] Figure 2b It can be seen that within the concentration range of (0-30 μM) thiophenol, the concentration of thiophenol has a linear relationship with the fluorescence intensity, and the fluorescence intensity gradually remains unchanged as the concentration of thiophenol in the probe solution continues to increase.

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PUM

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Abstract

The invention relates to preparation and application of a long wavelength colorimetric fluorescent probe capable of rapidly and high-selectively analyzing thiophenol. In specific, the probe is a 2, 4-dinitrophenylate compound which can serve as the thiophenol colorimetric fluorescent probe to detect thiophenol. The probe can achieve at least one of the following technical effects: high-selectivelyidentifying thiophenol; rapidly responding to thiophenol; achieving high sensitivity analysis on thiophenol; being stable in quality, capable of being reserved and used for a long time; and having the strong anti-jamming capability.

Description

technical field [0001] The invention relates to 2,4-dinitrophenyl ether compounds as long-wavelength colorimetric fluorescent probes for thiophenols, which can quickly and sensitively identify thiophenols with high selectivity, or can determine the concentration of thiophenols in samples . Background technique [0002] As an industrial raw material, thiophenol is widely used in the fields of medicine, pesticide, polymer material and organic synthesis. In terms of pharmaceutical raw materials, it is used in the production of local anesthetics and thiamphenicol, etc. In agriculture, thiophenol is an important synthetic raw material for the manufacture of insecticides and herbicides. In the field of polymer materials, it is used to synthesize polymer resin vulcanizing agents, copolymerization agents, adhesives, etc., and has a wide range of uses. However, thiophenol is also a highly toxic compound. Once released into the environment, it will quickly accumulate in the environ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/78C09K11/06G01N21/64G01N21/31
CPCC07D311/78C09K11/06C09K2211/1007C09K2211/1088G01N21/31G01N21/643
Inventor 李雪妍张萌吴柳赵子扬柳彩云朱宝存
Owner UNIV OF JINAN
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