A kind of preparation method of artificial cardiovascular and cerebrovascular

A cardiovascular and cerebrovascular and artificial technology, applied in prosthetics, medical science, etc., can solve problems such as cardiovascular and cerebrovascular blockage, achieve high tissue compatibility, improve compliance, and simple preparation methods

Active Publication Date: 2021-03-09
曹磊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the artificial cardiovascular and cerebrovascular prepared by this method has good biocompatibility, high unblocking rate and simple preparation, which brings hope for solving the blockage problem of cardiovascular and cerebrovascular

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of artificial heart and cerebrovascular, it comprises the following steps:

[0027] (1) Prepare the main structure of blood vessels:

[0028]a. Pulverize the plant fiber material and filter it with a sieve to obtain a plant fiber powder with a particle size of 0.03-0.05mm; place the plant fiber powder in an exoglucanase solution at 55-62°C for a stirring reaction for 5.5- 6 hours, the mass fraction of the exoglucanase was 1.5-1.8%, the mass volume ratio of the plant fiber powder to the exoglucanase solution was 1.5:1, and then the remaining Exoglucanase, dialyzing the reacted mixture into a neutral solution, freeze-drying at -25 to -28°C to obtain the first cellulose; dissolving the first cellulose in caustic soda and carbon The mixed solution of amides is frozen for 1.5-2.5 hours, then stirred and mixed with sodium periodate for 2.5-3.5 hours in a dark state at 50-58°C, then washed with alcohol until neutral, and freeze-dried to obtain the second ...

Embodiment 2

[0041] A preparation method of artificial heart and cerebrovascular, it comprises the following steps:

[0042] (1) Prepare the main structure of blood vessels:

[0043] a. Pulverize the plant fiber material and filter it with a sieve to obtain a plant fiber powder with a particle size of 0.03-0.05mm; place the plant fiber powder in an exoglucanase solution at 55-62°C for a stirring reaction for 5.5- 6 hours, the mass fraction of the exoglucanase was 1.5-1.8%, the mass volume ratio of the plant fiber powder to the exoglucanase solution was 1.5:1, and then the remaining Exoglucanase, dialyzing the reacted mixture into a neutral solution, freeze-drying at -25 to -28°C to obtain the first cellulose; dissolving the first cellulose in caustic soda and carbon The mixed solution of amides is frozen for 1.5-2.5 hours, then stirred and mixed with sodium periodate for 2.5-3.5 hours in a dark state at 50-58°C, then washed with alcohol until neutral, and freeze-dried to obtain the second...

Embodiment 3

[0056] A preparation method of artificial heart and cerebrovascular, it comprises the following steps:

[0057] (1) Prepare the main structure of blood vessels:

[0058]a. Pulverize the plant fiber material and filter it with a sieve to obtain a plant fiber powder with a particle size of 0.03-0.05mm; place the plant fiber powder in an exoglucanase solution at 55-62°C for a stirring reaction for 5.5- 6 hours, the mass fraction of the exoglucanase was 1.5-1.8%, the mass volume ratio of the plant fiber powder to the exoglucanase solution was 1.5:1, and then the remaining Exoglucanase, dialyzing the reacted mixture into a neutral solution, freeze-drying at -25 to -28°C to obtain the first cellulose; dissolving the first cellulose in caustic soda and carbon The mixed solution of amides is frozen for 1.5-2.5 hours, then stirred and mixed with sodium periodate for 2.5-3.5 hours in a dark state at 50-58°C, then washed with alcohol until neutral, and freeze-dried to obtain the second ...

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Abstract

The invention relates to a preparation method of artificial heart and cerebral vessels. The preparation method comprises the following steps: (1) preparing a blood vessel main body structure; (2) performing the biological treatment for the blood vessel main body structure; (3) preparing an intermediate layer on the outer surface of the blood vessel main body structure; (3) and preparing an outermost layer on the outer surface of the intermediate layer. By adopting the preparation method disclosed by the invention, the compliance of the artificial heart and cerebral vessels can be greatly improved, so that the degradation rate of the blood vessels and the tissue reconstruction rate are basically kept consistent, and the mechanical stability of the artificial heart and cerebral vessels can be improved. Meanwhile, the artificial heart and cerebral vessels prepared by the method is good in biological compatibility, high in circulation, simple in preparation, and capable of solving the congestion problem of the heart and cerebral vessels.

Description

technical field [0001] The invention relates to the technical field of tissue engineering in medical treatment, in particular to a method for preparing artificial heart and brain vessels. Background technique [0002] Cardiovascular and cerebrovascular diseases have become the number one killer threatening national health in our country. Among the elderly in China, the incidence rate of cardiovascular and cerebrovascular diseases is as high as 30%. The relevant institutions in my country have reported that the death due to cardiovascular and cerebrovascular accidents accounts for more than 50% of the total deaths. With the continuous surge of the aging population in our country, the number of patients is still increasing The increase will bring a heavy burden to our national economic construction. Vascular replacement surgery is widely used in the treatment of arterial stenosis, aneurysm, atherosclerosis and other vascular diseases. However, autologous blood vessel transplan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/20A61L27/22A61L27/18A61L27/58A61L27/50A61L27/56
CPCA61L27/18A61L27/20A61L27/225A61L27/507A61L27/56A61L27/58C08L1/02C08L75/04
Inventor 曹磊刘红梅刘国远
Owner 曹磊
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