Bone fracture healing simulation system based on mechanical stimulation and biological united stimulation

A fracture healing and mechanics technology, applied in the field of biomedical engineering, can solve the problem that the fracture healing area model and material property settings are too simplified, the joint regulation of mechanical factors and biological factors is not established, and there is no deterministic relationship between differentiation and apoptosis, etc. problems, to reduce delayed union, improve the quality of fracture healing, and shorten the training period

Inactive Publication Date: 2018-09-07
HARBIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. There is no individualized model specifically for patients;
[0005] 2. The joint regulation of mechanical factors and biological factors has not been established;
[0006] 3. There is no definite relationship between mechanical factors and cell proliferation, differentiation and apoptosis;
[0007] 4. The model and material property settings of the fracture healing area are too simplified

Method used

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  • Bone fracture healing simulation system based on mechanical stimulation and biological united stimulation
  • Bone fracture healing simulation system based on mechanical stimulation and biological united stimulation
  • Bone fracture healing simulation system based on mechanical stimulation and biological united stimulation

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specific Embodiment approach 1

[0030] Specific implementation mode one: as figure 1 As shown, a fracture healing simulation system based on the joint regulation of mechanical stimulation and biological stimulation described in this embodiment includes:

[0031] Fracture area analysis model establishment module 1, fracture area mechanical control modeling module 2, fracture area biological control modeling module 3, fracture area force-biological joint control modeling module 4 and program termination judgment module 5;

[0032] Fracture area analysis model 1 building module is used to establish fracture area geometric model and finite element model;

[0033] The mechanical control modeling module 2 of the fracture area is used to model the mechanical properties of the fracture area and solve the mechanical stimulation of the units in the fracture area;

[0034] The biological regulation modeling module 3 of the fracture area is used to model the biological characteristics of the fracture area, and solve th...

specific Embodiment approach 2

[0038] Specific implementation mode two: as Figure 1-5 As shown, in this embodiment, the specific process of the described fracture area analysis model building module 1 to realize its function is as follows:

[0039] 1) The establishment of a three-dimensional surface geometric model of the fracture area;

[0040] Using the segmentation-based 3D medical image surface reconstruction algorithm to reconstruct the surface of the image, and obtain the 3D surface geometric model through the process of threshold screening, interactive segmentation and 3D reconstruction;

[0041] The image is obtained by imaging equipment CT, and the data storage format is DICOM;

[0042] 2) Establishment of the finite element model of the fracture area;

[0043] Mesh the three-dimensional surface geometric model of the fracture area, discretize the continuous geometric model, and obtain the finite element model of the fracture area;

[0044] The meshing includes two steps of surface meshing and ...

specific Embodiment approach 3

[0049] Specific implementation mode three: as Figure 1-5 As shown, in this embodiment, the specific process of the fracture area mechanical regulation modeling module 2 to realize its function is as follows:

[0050] 1) Apply an external load on the finite element model of the fracture area, and set the boundary and initial conditions;

[0051] The magnitude of the external load is determined by the force that the bone bears, and the external loads received are also different for different experimental objects;

[0052] The boundary and initial conditions are obtained from CT image information;

[0053] 2) The fracture area is regarded as a dual-phase poroelastic model, and the constitutive equation, equilibrium equation and geometric equation of the fracture area unit are obtained from the poroelastic theory, and the distortion strain D and the fluid flow rate received by the fracture area unit are calculated by the finite element method V, the specific process is:

[0054]...

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Abstract

The invention provides a bone fracture healing simulation system based on mechanical and biological joint adjustment and control and relates to the field of biomedical engineering. The system comprises a bone fracture area analysis model establishing module, a bone fracture area mechanical adjustment and control modeling module, a bone fracture area biological adjustment and control modeling module, a bone fracture area mechanical and biological joint adjustment and control modeling module and a program determination judging module. The bone fracture area analysis model establishing module isused for establishing a bone fracture area geometrical model and a finite element model. The bone fracture area mechanical adjustment and control modeling module is used for solving mechanical simulation exerted to a bone fracture area unit. The bone fracture area biological adjustment and control modeling module is used for related cell concentration, growth factor concentration and extracellularmatrix concentration. The bone fracture area mechanical and biological joint adjustment and control modeling module is used for achieving joint adjustment and control of mechanical and biological simulation. The program determination judging module is used for judging program determination. The bone fracture healing simulation system provides beneficial help for finding of the bone fracture healing schemes by simulating the bone fracture healing process.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a fracture healing simulation system based on joint regulation of mechanical stimulation and biological stimulation. Background technique [0002] Fracture is a common trauma, and the high incidence of fracture makes the study of fracture healing mechanism and promotion of fracture healing particularly urgent. Unlike other tissue injuries, fractures are not connected by fibrous connective tissue, but complete regeneration of bone tissue. However, not all fractures heal completely and sometimes delayed union or even nonunion occurs. Delayed union or nonunion of fractures can cause pain and dysfunction in the affected limb, leading to unemployment of the patient, which causes a great social and economic burden. Therefore, although the research on fracture healing has been receiving much attention, there are still 5% to 10% of fractures with delayed union or even nonunion due...

Claims

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Application Information

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IPC IPC(8): G16H50/50G06F17/50
CPCG06F30/23G06F2119/06G16H50/50
Inventor 王沫楠杨宁
Owner HARBIN UNIV OF SCI & TECH
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